DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and vav3b

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_005163380.1	Gene:	vav3b / 559145	ZFINID:	ZDB-GENE-070912-251	Length:	853	Species:	Danio rerio

Alignment Length:	758	Identity:	135/758 - (17%)
Similarity:	280/758 - (36%)	Gaps:	182/758 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 ESLDRLTDIKPKFAARLSELARLNNRPLS-SSSICSTSSSSSSGSDQLLNGKLMATSYLASVESL 523
            |:.| |.|:: .|...:..|::|:..|:: .|.|.|..:..|:.::.:         |:...:.:
Zfish    95 EAFD-LFDVR-DFGKVIDTLSKLSYTPVAQQSGIRSFPTEESTENEDI---------YIHLADLI 148

  Fly   524 AESENELGDQHHPPAMSVLE-------------------------KTC--LEIVDSERSFVEDLG 561
            .|   ||.:..:.|....:|                         ::|  |||..:|..:.|.|.
Zfish   149 DE---ELEEDVYDPVYGDIEGGEVYEDLMRTEAAVSQAKQAEVDIRSCCLLEIKQTEAKYTETLE 210

  Fly   562 QVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLIN--TGRDPGRIARCFIDLRDGF 624
            .:.|.::....:  .:...::..:|.||.::.:.:..|:..:.:  ..::...:.:.||..:|..
Zfish   211 TIEKYFMIPLMK--FIPATDIDKVFINIPDLVKVHKGLMGEIQDCVQNKNAENLHQIFITYKDRL 273

  Fly   625 DVYTTYCTSYPEAISLLTKLLQATHTYSL-LASTQKLLQH-RLPLGSYLLKPVQRILKYHLLLDS 687
            .:|..||:....|||||..:.:......| |....|...: :..|...|:.|:||:|||.|||..
Zfish   274 LLYGKYCSHVESAISLLDFICKEKEGVRLKLEECSKRANNGKFTLRDLLVVPMQRVLKYPLLLQE 338

  Fly   688 LRKH-------CDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGEL 745
            |.|:       .:::..::|   ||.:|..:::|||..|....:.:....::. |...|...|..
Zfish   339 LVKYTNDGPEKSNLRIALDA---MRDLAQYVNEVKRDVETLREIDQYQRSIEN-LNQSLLSYGRP 399

  Fly   746 RQEGLL-----MEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEP----T 801
            :.:|.:     :::..:.|.:.||...:||.|::.| ..:.|..|..::..::.:|..:.    :
Zfish   400 KGDGEVRLVSNLDKRRQDRHIFLFDAAVIICKRRGD-NYEMKEVIDLSHFKITNNLADKDCRKWS 463

  Fly   802 SFYVIPFDEPRHQIKLTARNRDQKRIW-------------------TQHIKGVMLEKLDIPMRAK 847
            |.:.:...:.:...:...:.::.|:.|                   :.|.:....|:.......:
Zfish   464 SGFYLTHQQGQSGFEFLFKTKELKKKWLDQFEMAISNIRPENATFNSHHFRMHTFERATTCSSCR 528

  Fly   848 ELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDS 912
            .|:..:.|:....|         ..|:.:....|.:...|.|:....:  |.:|||...
Zfish   529 MLLRGIFNQGYLCP---------KCGNGAHKGCLGKLGVCGRTGAAVQ--KPQRKTTPR------ 576

  Fly   913 FNESLEQEEESISQ----------AKPSKPLARNNSLDDTALQKLAA---AMRYRKRDAAVKEET 964
                 :||:..:.:          :||....|.|..:.| .::.:.|   :..::.:....:|..
Zfish   577 -----KQEDPGLPKMLVIRDYFGVSKPQGGQALNAQIGD-VIEVVYADPHSSWWQGKILTTQETG 635

  Fly   965 KTPVKEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEE 1029
            ..|             .:.::||.|:.|            ...|       .|.|...|......
Zfish   636 FFP-------------SDAVKPCPCVPR------------TVDY-------SSQPWFAGPMERHH 668

  Fly  1030 AEREREQDEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSCSRFY 1094
            ||.|..:.|:|...:|       .|..:.:.:....:||:        ::|..:..|.:.|  ||
Zfish   669 AESELMERENSTYLVR-------YRSRESREYAISIKYNN--------DVKHLKVLTKEGC--FY 716

  Fly  1095 MDLSEFDSSSSTVLKITESTEELRPDGEIELAQEAATLDESTQ 1137
            :      :.|.|...:....|..:   :..|.:...|||.:.|
Zfish   717 I------AESRTFKNVLGLVEYYK---QHSLKEGFRTLDTTLQ 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	41/175 (23%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	26/172 (15%)
vav3b	XP_005163380.1	CH	4..115	CDD:278723	6/21 (29%)
		RhoGEF	194..368	CDD:279015	42/178 (24%)
		PH_Vav	381..503	CDD:269930	17/123 (14%)
		PH	406..499	CDD:278594	13/93 (14%)
		C1	511..556	CDD:237996	7/53 (13%)
		SH3	585..644	CDD:302595	8/72 (11%)
		SH2	653..755	CDD:301589	26/131 (20%)
		SH3_VAV3_2	798..852	CDD:212911
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940