Protein Alignment GEFmeso and arhgef6

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_068069464.2
• Gene: arhgef6 / 558288
• ZFINID: ZDB-GENE-101013-2
• Length: 799
• Species: Danio rerio
• Alignment Length: 633
• Identity: 131/633 - (20%)
• Similarity: 233/633 - (36%)
• Gaps: 174/633 - (27%)

  Fly   548 EIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDP-- 610
            :|::.||.||::|..|:.|||:..:....|...:...|..|:|:|..|...|...|....:.|
Zfish   246 DILEHEREFVKELQNVLGGYLRPLQASDKLSSVDCSSLNGNLEDILSFQQGLCLTLEECSKVPEG 310

  Fly   611 -GRIARCFIDLRDGF-DVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHR-------LP 666
             .||..|::::.... .:|.:||:|:|.|:.:||     .|:..|    .|.::.:       |.
Zfish   311 QQRIGGCYLNMMCQIRTLYLSYCSSHPSAVCVLT-----DHSEEL----DKFMESQGASAPGILT 366

  Fly   667 LGSYLLKPVQRILKYHLLLDSLRKHC-----DVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKE 726
            |.:.|.||..|:.||..||..|.:|.     |..::::|....:.:......:::::..:.::
Zfish   367 LTTSLSKPFMRLDKYPTLLQELERHVEEAHPDYSDILKATAAFKNLVTQCQDLRKRKNLELQI-- 429

  Fly   727 LSGILDGWLGPELTVLGELRQEGLLMEQ---------HNKQRLVLLFATMLI------------- 769
            ||..:.||.|..:..||::    :.|.|         ..::|..:||..::|
Zfish   430 LSEPVRGWEGDSMKSLGQV----IYMSQIHMQSSANEEKEERYFMLFPNVIIMLSASPRMSGFIY 490

  Fly   770 ----------ITKQKED---GRLQF--------KTYISQNNLMLS----EHL-----PGEP--TS 802
                      :|||.||   |...|        :|.:..::|...    |||     .|.|  |.
Zfish   491 QGRLPLTGTSVTKQPEDAETGHYAFEITGGSIDRTMVFCSSLQEQQDWLEHLHPYIKVGSPFETV 555

  Fly   803 FYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLG----NEEDRTPDR 863
            ..||.|......|:|   |.....::...::.|.::.|.:|..:...::..|    |.....|.:
Zfish   556 LKVIAFFAAFTSIQL---NSKSNVMFLCILQSVDVKPLTMPGTSSHHLHGFGTTAVNRGPLEPPK 617

  Fly   864 STWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEESISQAK 928
            .|..|||               :|.|.           ......|:...:.|...:....|.:..
Zfish   618 ITKPWSL---------------SCLRP-----------APPLKPSAALGYKEDSSKSPRPIKKFL 656

  Fly   929 PSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVKEPCKCDQDAKQDERIEP-CSCILR 992
            |.:...|..|.|:..|:|..||:                       ::||:..:.||. |:
Zfish   657 PKRKTERKPSDDEFLLRKSTAAL-----------------------EEDAQILKVIEAYCT---- 694

  Fly   993 DQRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEEAER--------------EREQDEDSAAS 1043
               ..|....:..|.:...||   .||::    |..|.|:              |.:...|:..:
Zfish   695 ---GASLHQSTTGFMFSVRKE---CVPQV----LLPEEEKIIVEDIKSNGQTTIEEKSLVDAVYA 749

  Fly  1044 LRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSCS 1091
            |:....:|.:.....|...|.:|.:.|.:.:.:..|.||::    .||
Zfish   750 LKDEVHELKKENKWMKQCLEEEQKSRKELERVVRKLAKQKN----DCS 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	47/179 (26%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	36/198 (18%)
arhgef6	XP_068069464.2	None