DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GEFmeso and vav2

DIOPT Version :9

Sequence 1:NP_788403.2 Gene:GEFmeso / 37134 FlyBaseID:FBgn0050115 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_021324720.1 Gene:vav2 / 556413 ZFINID:ZDB-GENE-091204-420 Length:891 Species:Danio rerio


Alignment Length:813 Identity:161/813 - (19%)
Similarity:288/813 - (35%) Gaps:239/813 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   465 LTDIKPKFAARLSELARLNN---------RPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASV 520
            |.|:: .|...:|.|:|:::         ||..|             .|..||    ......|:
Zfish    99 LFDVR-DFGKVISALSRISHNSIAQIKGIRPFPS-------------EDTALN----EDDVYRSL 145

  Fly   521 ESLAESENELGDQ-----------------------------HHPP-----------AMSVLE-- 543
            |.||: |:::|:.                             ..||           .|.:.|  
Zfish   146 EELAD-EHDVGEDDIYDCVPCEDDGDDIYEDIIKVEVRQPMVSEPPYGRRSLIRYMQKMGMTEDD 209

  Fly   544 -KTC--LEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQ---- 601
             :.|  :||.::|..:.:.|..:.|.|:...|:  .|...|::.:|.|:|:|...:..||:    
Zfish   210 KRNCCLVEIQETEAKYYKTLEDIEKNYMIPLKQ--VLTPQEMEAIFVNLEDIIRVHFALLRAIDL 272

  Fly   602 RLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLAS--TQKLLQHR 664
            .:::.|...|:|   |:|.::...:|..||:....|...|.:|:...........  |.|:.:.:
Zfish   273 TMVSGGNGLGKI---FLDFKERLLIYGQYCSHMENAQKTLDELIATREDVKCKVEECTMKVQEGK 334

  Fly   665 LPLGSYLLKPVQRILKYHLLLDSLRKHC-------DVKEVVEAHVIMRQVAHNIDQVKRKQEQQS 722
            ..|...|:.|:||:|||||||..|..|.       .:||.:||   |:.:|..|::|||..|...
Zfish   335 FKLQDLLVVPMQRVLKYHLLLKELVSHSMDRPERQQLKEALEA---MQDLAMYINEVKRDNETLK 396

  Fly   723 RVKELSGILDGWLGPELTVLGELRQEGLL-----MEQHNKQRLVLLFATMLIITKQKEDGRLQFK 782
            ::.|....::. |..:|...|..:.:|.|     :.:..:.|.:.||..::|:.|:| ....:.|
Zfish   397 KISEFQSSIEN-LQVKLEEYGRPKIDGELKVCSIVNRTKQDRYIFLFDKVVIVCKRK-GYNYELK 459

  Fly   783 TYISQNNLMLSEHLPGEPTS---------------FYVIPFDEPRHQIKLTARNRDQKRIWTQHI 832
            ..|..:...:|:    :|.:               ||:|.. :.:...:...:..|.||.|    
Zfish   460 EVIELHLYKMSD----DPMNNRDMKKSSGKMWSYGFYLIHL-QGKQGFQFFCKTEDTKRKW---- 515

  Fly   833 KGVMLEKLDIPMRAKELVYQLGNEEDRTPDRST---WKWSLHSGSNSTPTYLERRNACRRSEIRQ 894
                :|:.::.|            .:..|:|:|   ..:.:|:        .|:...||..::..
Zfish   516 ----MEQFEMAM------------SNIKPERATANQHNFQMHT--------FEKNTNCRACKMLL 556

  Fly   895 RNSKFKRKTVANSSSFDSFNESLE----------QEEESISQAKPSKPLARNNSLDDTALQKLAA 949
            |.. |.:....:.....:..|.||          ..|..:.|:.|                |:.|
Zfish   557 RGI-FYQGYYCSLCGTGAHKECLEIITICKISPHDSEPGLPQSGP----------------KMVA 604

  Fly   950 AMRYRKRDAAVKEETKTPVKEPCKCDQDAKQDERI--EPCSC-----ILRDQR-----SRSAKSQ 1002
            ...|....|       .|.|.|. |.|..:..|.:  :|.:.     :::.|:     |.|.|..
Zfish   605 IRNYHGTPA-------PPGKIPL-CFQTGEVIELLKGDPDTSWWEGKLIQTQKTGYFPSSSVKPC 661

  Fly  1003 SPVFSYKALKERSKS-------VPRIGGFSLDEEAEREREQDEDSAASLRGSKPDLSERKTKGKG 1060
            .....::|...|..|       .|...|       ..||:|.::...|.......:.||..:.:.
Zfish   662 LDPKPFQAFSNRQSSRETDYYVYPWFAG-------NMERQQADNLLKSHSSGTYLIRERTAEAER 719

  Fly  1061 FFEVKQYNHKTMPKKIANLKKQRSSTTKSCSRF--YMDLSEFDSSSSTVLKITESTEELRPDGEI 1123
            |....::|.:.  |.|..::|..........:|  .::|.|:..|.|                  
Zfish   720 FAISIKFNDEV--KHIKVIEKDNWIHITEAKKFESLLELVEYYQSHS------------------ 764

  Fly  1124 ELAQEAATLDESTQDQYYSPDH---ETELLSPA 1153
             |.:....||.:.:..|.|.:.   .|...|||
Zfish   765 -LKESFKLLDTTLRYPYKSRERSSSRTNTRSPA 796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GEFmesoNP_788403.2 RhoGEF 548..713 CDD:279015 49/177 (28%)
PH_PLEKHG1_G2_G3 694..839 CDD:270063 34/164 (21%)
vav2XP_021324720.1 CAMSAP_CH 18..103 CDD:314792 2/3 (67%)
RhoGEF 211..386 CDD:238091 49/182 (27%)
PH_Vav 401..528 CDD:269930 24/153 (16%)
C1 536..579 CDD:237996 7/51 (14%)
SH3 601..660 CDD:327375 14/66 (21%)
SH2_Vav2 680..782 CDD:198269 22/129 (17%)
SH3_VAV2_2 832..889 CDD:212910
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.940

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