Protein Alignment GEFmeso and arhgef7a

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_021334338.1
• Gene: arhgef7a / 553493
• ZFINID: ZDB-GENE-060322-11
• Length: 864
• Species: Danio rerio
• Alignment Length: 953
• Identity: 181/953 - (18%)
• Similarity: 345/953 - (36%)
• Gaps: 241/953 - (25%)

  Fly   331 PGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKT 395
            |||           .:.:..:|.:..:.:..|...|....:.|:...:.||| .:...|..|..|
Zfish    50 PGT-----------TDKIIQDPKNDSECLSNITEFLKGCAVFRVEPFEAGDL-LQGHNISRVLTT 102

  Fly   396 LVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAE 460
            ||....|.:.....:.::|:.....: |.||..:.||....|...|| ...|...|
Zfish   103 LVALNKVTADIGIGSDSVCTRHSSAH-RIKSFESLASQSSLGRSSKL-LHNQFRSL--------- 156

  Fly   461 SLDRLTDIKPKFAARLSELARLN-------NRPLSSSSICSTSSSSSSG-SDQLLNGKLMATSYL 517
             :..:.|:.....|:|...||.|       ....|...:.|.:.:...| .:.:||||   |.:.
Zfish   157 -VSNIGDMTDNSNAQLVVKARFNFQQTNEDELTFSKGDLISVTRTEEGGWWEGILNGK---TGWF 217

  Fly   518 AS--VESLAESENEL----GDQHHPPA---MSVLEKTCLEIV-----DSERSFVEDLGQVIKGYL 568
            .|  |:.:..|:.::    |:...||.   .:.:.||...:|     ::|..:..:|..::..||
Zfish   218 PSNYVKEVKGSDKQVSPKSGNLKSPPKGFDTASISKTYYNLVLQNILETETEYSRELQNLLTSYL 282

  Fly   569 QDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDP---GRIARCFIDLRDGF-DVYTT 629
            :..:....|...::.::..|:|||..|...|:|.|.:..:.|   .::...|::|.... .:..:
Zfish   283 RPLQMTERLSPADVSVILGNLEEISTFQQTLVQSLEDLTKLPELQQKVGGFFLNLMPQMRSLNVS 347

  Fly   630 YCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHR-------LPLGSYLLKPVQRILKYHLLLDS 687
            ||:::|..:::||     .|:..|    .:.::.|       |.|.|.|.||..|:.:|..||..
Zfish   348 YCSNHPSTVNVLT-----VHSEEL----GEFMEARGASVPGILTLTSGLSKPFMRLDRYPTLLKE 403

  Fly   688 LRKHC-----DVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQ 747
            |.:|.     |..|:.:.....:.::....:|::::|.:.::  |:..:..|.|.::..||.:..
Zfish   404 LERHMEEGHPDRTEIQKCMTAFKNLSAQCQEVRKRKELELQI--LAETIRLWEGEDIKTLGSVLY 466

  Fly   748 EGLLMEQHN-----KQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIP 807
            ....|.|::     .:|.:|||..:|:|.....    :...:|.|..|.||        ...|.|
Zfish   467 MSQAMVQNHGCEEKNERYLLLFPHVLLILSASP----RMSGFIYQGKLPLS--------GMTVTP 519

  Fly   808 FDEPR-------------HQIKLTARNRDQKRIWTQHIK---------GVMLEKLDIPMRAKELV 850
            .::..             .::::...|:.....|.:|:.         ...::.|.:|.....
Zfish   520 LEDCESHKDAFELSGSMFERLQVICYNKQDLHDWLEHLNRQTKHTTMAAPSMKPLTVPCHTLP-- 582

  Fly   851 YQLGNEEDRTPDRSTWKWSLHS---GSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDS 912
                 ....||.|       |.   |....|.|                     .|:.:.||..:
Zfish   583 -----SHPLTPSR-------HGESRGLTVAPAY---------------------HTLPHPSSHGT 614

  Fly   913 FNESL---------EQEEESISQAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPV 968
            .:.::         .|:..|:|..:|:.||            :.:||:.|:      ::.:|:|
Zfish   615 PHSTMMWGPLEPPKTQKPWSLSCLRPAPPL------------RPSAALCYK------EDLSKSP- 660

  Fly   969 KEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYK----ALKERSKSVPRIGGFSLDEE 1029
                      |..:::.|       :|....|.....|:.:    ||:|.::.:..|..:....:
Zfish   661 ----------KTMKKLLP-------KRKPERKPSDEEFALRKSTVALEEDAQILKVIEAYCTSAK 708

  Fly  1030 AEREREQ-------------DEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIANLKK 1081
            ..:....             |:.||.|| |.:..:| |........|...|:         ::..
Zfish   709 TRQTLNSTWQGTDLMHNHVLDQSSADSL-GRRSSIS-RPEATSDLSEDSDYD---------SIWT 762

  Fly  1082 QRSSTTKSCSRFYMDLSEFDSSSSTVLKITE--STEELRPDGEIELAQEAATLDESTQDQYYSPD 1144
            ..|....|.:|.:.     |.|.:.::...|  |.:||:.:|: .|.:|.:.:|.    .|...|
Zfish   763 AHSYRMGSVTRQWK-----DGSPALIVPGDEKFSVDELKSNGQ-TLLEEKSLVDV----VYALRD 817

  Fly  1145 HETELLSPAEKSKRDAQIVLDLLKNSKEFERIYNKQQKRRESP 1187
            ...||....:|.|:..:   :..:..|:.|||..|..|....|
Zfish   818 EVQELKQDYKKMKKSLE---EEQRARKDLERIVKKMLKNMNDP 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	39/184 (21%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	26/171 (15%)
arhgef7a	XP_021334338.1	CH_SF	4..114	CDD:469584	16/75 (21%)
		RhoGEF67_u1	116..168	CDD:465201	12/63 (19%)
		SH3_alphaPIX	170..226	CDD:212993	14/58 (24%)
		RhoGEF	256..433	CDD:238091	39/185 (21%)
		PH_Cool_Pix	464..562	CDD:269932	18/109 (17%)
		RhoGEF67_u2	621..711	CDD:465200	20/125 (16%)
		betaPIX_CC	779..863	CDD:465158	22/87 (25%)