Protein Alignment GEFmeso and Arhgef7

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_036010059.1
• Gene: Arhgef7 / 54126
• MGIID: 1860493
• Length: 919
• Species: Mus musculus
• Alignment Length: 970
• Identity: 188/970 - (19%)
• Similarity: 344/970 - (35%)
• Gaps: 273/970 - (28%)

  Fly   371 MERLTLADPGDL-----DPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLT--------YA 422
            :|||.   ||.:     :||.|     ::.|.|   :|....||.:::....|.|        |.
Mouse    45 LERLL---PGTIEKVYPEPRNE-----SECLSN---IREFLRACGASLRLEKLDTRTSVSFHLYL 98

  Fly   423 RTKSLGAKASTLGGGVPIKLPTAEQLAELEEANK---LSA--ESLDRLTDI--KPKFAARLSELA 480
            :|.........:|.|..:.:...:.|::.|.::.   |||  ::.| ..|:  ...|...||.|.
Mouse    99 KTNQNCDGGGAVGSGDALDVCNQKYLSDRETSHGVLCLSAAPQTFD-ANDLYQGQNFNKVLSSLV 162

  Fly   481 RLN----NRPLSSSSICSTSSSS--------SSGSDQLLNGKLMATSY---------------LA 518
            .||    :..|.|.|:|:..||.        .|.|......||:.:.|               .|
Mouse   163 TLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSSHSRTSKLLQSQYRSLDMTDNTNSQLVVRA 227

  Fly   519 SVESLAESENEL----GDQHH-------------------------------------------- 535
            .......:|:||    ||..|
Mouse   228 KFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLK 292

  Fly   536 -PPA---MSVLEKTCLEIV-----DSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEE 591
             ||.   .:.:.|:...:|     ::|..:.::|..|:..||:..:....|.......|..|:||
Mouse   293 SPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLRPLQTSDKLSSANTSYLMGNLEE 357

  Fly   592 IYEFNSMLLQRLINTGRDP---GRIARCFIDLRDGF-DVYTTYCTSYPEAISLLTKLLQATHTYS 652
            |..|..:|:|.|....:.|   .|:..||:.|.... .:|..||.::|.|:|:||:     |:..
Mouse   358 ISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTE-----HSED 417

  Fly   653 L-------LASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC-----DVKEVVEAHVIMR 705
            |       .||:..:    |.|.:.|.||..|:.||..||..|.:|.     |.:::.::....:
Mouse   418 LGEFMETKGASSPGI----LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFK 478

  Fly   706 QVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLM-----EQHNKQRLVLLFA 765
            .::....:|::::|.:.::  |:..:..|.|.::..||.:.....:.     .:...:|.:|||.
Mouse   479 NLSAQCQEVRKRKELELQI--LTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFP 541

  Fly   766 TMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIP--FDEPRHQIKLTARNRDQKRIW 828
            .:|::.....    :...:|.|..|         ||:...|.  .|...|      ||..:
Mouse   542 NLLLMLSASP----RMSGFIYQGKL---------PTTGMTITKLEDSENH------RNAFE---- 583

  Fly   829 TQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIR 893
               |.|.|:|::.:...:::.:::               |..|
Mouse   584 ---ISGSMIERILVSCTSQQDLHE---------------WVEH---------------------- 608

  Fly   894 QRNSKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKPLARNNSLDDT-------ALQKLAAAM 951
                 .:::|...|.|    |.:::..... |...||.||..::...|:       |...|....
Mouse   609 -----LQKQTKVTSVS----NPTIKPHSVP-SHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPS 663

  Fly   952 RYRKRDAAVK----EETKTPVKEPCKCDQDAKQDERIEPCSCI-LRDQRSRSAKSQSPVFSYKAL 1011
            .:......:.    |..|||......|.:.|..   :.|.:.: .::..|:|.|:...:.. |..
Mouse   664 HHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPP---LRPSAALCYKEDLSKSPKTMKKLLP-KRK 724

  Fly  1012 KERSKSVPRIGGFSLDEE--AEREREQDEDSAASLRGSKPDLSERKTK--------GKGFFEVKQ 1066
            .||..|         |||  ..:.....|:.|..|:..:...:..||:        |...    .
Mouse   725 PERKPS---------DEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDL----M 776

  Fly  1067 YNHKTMPKKIANLKK--QRSSTTKSCSRFYMDLSEFDS----SSSTVLKITESTEELRPDGEIEL 1125
            :||.......::|..  :|||.::.......:.||:||    .|..:...:.|.:|..|  ::.|
Mouse   777 HNHVLADDDQSSLDSLGRRSSLSRLEPSDLSEDSEYDSIWTAHSYRMGSASRSRKESAP--QVLL 839

  Fly  1126 AQEAATLDESTQDQYYSPDHETELLSPAEKSKRDAQIVLDLLKNSKEFERIYNKQQKRRE 1185
            .:|...:.|.|:....:...|..|:......|.:.|   :|.:::|:.::...::|:.|:
Mouse   840 PEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQ---ELRQDNKKMKKSLEEEQRARK 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	46/184 (25%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	25/151 (17%)
Arhgef7	XP_036010059.1	CH_SF	3..172	CDD:469584	32/138 (23%)
		RhoGEF67_u1	174..220	CDD:465201	10/45 (22%)
		SH3_betaPIX	224..277	CDD:212994	7/52 (13%)
		RhoGEF	308..485	CDD:238091	46/185 (25%)
		PH_Cool_Pix	516..614	CDD:269932	21/165 (13%)
		RhoGEF67_u2	673..764	CDD:465200	22/103 (21%)
		betaPIX_CC	834..918	CDD:465158	13/68 (19%)