Protein Alignment GEFmeso and ARHGEF4

DIOPT Version :9

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_001354422.1
• Gene: ARHGEF4 / 50649
• HGNCID: 684
• Length: 1876
• Species: Homo sapiens
• Alignment Length: 997
• Identity: 220/997 - (22%)
• Similarity: 357/997 - (35%)
• Gaps: 253/997 - (25%)

  Fly     4 ESDSDTSERWEDFFG--SSTELAPSLLGIYDTLTNSFAAGGVAAAPTATS-----HESKASSSGD 61
            |:||...||.||..|  .|...||.|                |:.|.::|     |..|:..:..
Human   983 ETDSHCEERAEDKEGYVFSDHWAPPL----------------ASTPLSSSLVSPEHRRKSEPTIK 1031

  Fly    62 STPKRSN-----SNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSST-HLGHQEPPAPLVVAG- 119
            .|..:..     |......|..:|.||    |.:.....::||.|||. .|.::.|..|.....
Human  1032 CTATQEGGRYLPSGIFPEKSWLASPGS----PRAQQAGIAHTLPSSSACCLAYENPGTPCRPTSP 1092

  Fly   120 --LRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGS-----SRRGSNIRILSPNVHRIITHSDI 177
              |...|.       .||........||:.|:.|.||     |..|...|...|..
Human  1093 KPLSPRPS-------AQRMGLHYPGRGSAISMVSLGSYSYVDSSSGDPERPKIPKG--------- 1141

  Fly   178 QPVEAVSAEALKQHQQQSQ-RSPTQGRYIKTGHSGTPPAAGSAPKLK-----LSHIPLSKITGKL 236
            |....:|.:.|.|.:|:.: |...||          |...|:.|.|:     .:|:|..:..|:.
Human  1142 QTSFLLSLQTLNQDEQKEESREGGQG----------PRGLGTVPWLRDLPGSENHMPWEEPAGEK 1196

  Fly   237 STQSGSELVSTFDSSNE---YLNSVAFAAFEKSKPQDEDRTPTN-KSVP-GTPFHFDG---HPFQ 293
            .:.|.|:.....:.:.:   ..:.|.:|....|........|:. :.:| .:|...|.   ...|
Human  1197 PSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPHRSPVSVDDLWLEKTQ 1261

  Fly   294 GRKLTLPRY-----------------------DSQQSIKLIE----MEQLAATSAQLLHAKPATP 331
            .:||....:                       .|.:|:.|..    :.|.|.|....:.....||
Human  1262 RKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSHPLSQSAPTGLNHMGWPEHTP 1326

  Fly   332 GTPATPTPSATKAKEFVCSEPL-SPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKT 395
            || |.|..:...|   ||::.: |..|:.|.:       |......:.||....:.    |:|:
Human  1327 GT-AMPDGALDTA---VCADEVGSEEDLYDDL-------HSSSHHYSHPGGGGEQL----AINE- 1375

  Fly   396 LVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAE 460
                 |:...|..||..:.....:.   .:.||.||..:                :|..:..:.|
Human  1376 -----LISDGSVVCAEALWDHVTMD---DQELGFKAGDV----------------IEVMDATNRE 1416

  Fly   461 -SLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLA 524
             ...|:.|.:..|.|....|....:.|....:..:.:|.:..|..:..:.|
Human  1417 WWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSK-------------- 1467

  Fly   525 ESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDE-LQILFAN 588
                   ||.....::       ||:.:||.:::.|..:.:||::..::||.:..:| |:.:|.|
Human  1468 -------DQMRTNVIN-------EILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGN 1518

  Fly   589 IEEIYE----FNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEA---ISLLTKLLQ 646
            ||:||.    |...|.||..........:..||::.:..|.:|:.||.::|.|   :|.||||.:
Human  1519 IEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSK 1583

  Fly   647 ATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRK-----HCDVKEVVEAHVIMRQ 706
            ..:.:......||::.  :.|..:||.|||:|.||.|.|..|.|     |.|.|:|..|...|:.
Human  1584 YVYFFEACRLLQKMID--ISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKN 1646

  Fly   707 VAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTV-LGELRQEGLLM-----EQHNKQRLVLLFA 765
            ||..|::.||:.|...::.:....::.|.|.:|.| ..||...|.|.     :..::||:..||.
Human  1647 VAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFD 1711

  Fly   766 TMLIITKQKEDGR--LQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIK------------ 816
            ..||..|:....|  |.:|..:..:.|.:.:...|:....:|        .||
Human  1712 HQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHV--------SIKNAFRLHRGATGD 1768

  Fly   817 ---LTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTP 878
               |..|..:||:.|           |....|.:|.| ||..|                 :..:.
Human  1769 SHLLCTRKPEQKQRW-----------LKAFAREREQV-QLDQE-----------------TGFSI 1804

  Fly   879 TYLERRNACRRSEIRQRNSKFK 900
            |.|:|:.|...:..:|...|.|
Human  1805 TELQRKQAMLNASKQQVTGKPK 1826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	58/177 (33%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	38/167 (23%)
ARHGEF4	NP_001354422.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940