DRSC/TRiP Functional Genomics Resources

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Protein Alignment GEFmeso and GEFmeso

DIOPT Version :10

Sequence 1:NP_788403.2 Gene:GEFmeso / 37134 FlyBaseID:FBgn0050115 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_061519316.1 Gene:GEFmeso / 4576688 VectorBaseID:AGAMI1_007806 Length:1689 Species:Anopheles gambiae


Alignment Length:1854 Identity:616/1854 - (33%)
Similarity:862/1854 - (46%) Gaps:473/1854 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDIESDSDTSERWEDFFGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPK 65
            ||:|||.  ||||||||||||::.||:||..|||.|:|            |.|:|      ...:
Mosquito     1 MDVESDG--SERWEDFFGSSTDIGPSVLGYLDTLANNF------------SEEAK------QLVE 45

  Fly    66 RSNSNCSSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTH-LGHQEPPAPLVVAGLRDEPDGAQL 129
            .||:|   ...|.::|......| |...:..:.|...:.| :.|....|.....|:.   :|::.
Mosquito    46 SSNNN---KLQTPTATAPPPPAP-SPAVAIVHPLQRVAVHVIKHDTTSAGSGGGGVF---EGSEH 103

  Fly   130 SRLVQ-----RRS---QESQIHGSSSSIASSGSSRRGSN--IRILSPNVHRII--------THSD 176
            .|.|.     .||   :.:.:...|:...::|..::.|:  ..::||||.|::        |.|.
Mosquito   104 QRTVDGGEYPARSNLFRSAGLPPPSTGELNAGRVKKFSDKFFSLVSPNVQRMVSNTTDVNGTSSS 168

  Fly   177 IQPVEAVSAEALKQHQQQ------SQRSPTQGRYI-------KTGHSGTPPAAGSAPKLKLSHIP 228
            ...||  |:..|:.|.|.      |.|.|  ||.|       .||||.             .::|
Mosquito   169 SNGVE--SSVFLRNHVQSASFSAASSRKP--GRQIGTTMPLQVTGHSH-------------KNLP 216

  Fly   229 LSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQ 293
            |||...|| |...|||:....|.:.   .:|.|.:.:.: :...|.|..:.........||:   
Mosquito   217 LSKNIAKL-THVNSELMMDHHSVDA---PIAPARYRQHR-EAVIRVPGGQESKEETVVMDGN--- 273

  Fly   294 GRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPAT----PGTPATPT--PSATKAKEFVCSEP 352
            |...|..|..:..:      |:|...||..|..:..|    .||..|.|  ||::.|      .|
Mosquito   274 GNIATEKRRQNAPA------EELQNVSALQLKIRSLTVELENGTDPTTTTGPSSSAA------SP 326

  Fly   353 LSPVDIVDTINFDLV--AQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAAC------ 409
            :...:|.|.::.|:|  .......|..|...::...:|:|..| |:|.         ||      
Mosquito   327 VQAKEIGDPMDSDVVLRGNASNSGTTIDNAFVENCVDLVEHRN-TVVE---------ACNFYPNL 381

  Fly   410 ASTICSSP----LLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKP 470
            ..|:..||    .|..||.|.|.|. |.....:|.......::|. |::...|..|||.......
Mosquito   382 GRTVPPSPDDRRTLAEARAKLLDAN-SNCKAAIPASPKLNTRIAN-EQSTSTSTPSLDTSVGNGS 444

  Fly   471 KFAARLSELAR-----LNNRPLSSSSICS-TSSSSSSGSD-QLLNGKLMAT-SYLASVESLAE-S 526
            :::::.|.|..     |::||||:||||| :||:|||||: .|..||..|. ||.|||||||: |
Mosquito   445 QYSSKASLLIPPNTPVLSSRPLSASSICSYSSSASSSGSEHHLPGGKGSAPGSYQASVESLADHS 509

  Fly   527 ENELGDQH--------HPPA------------MSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDW 571
            |.|   ||        |..|            |::.|:...||:|||.|:|:||||||:|||:||
Mosquito   510 EPE---QHGGNLLLLRHCDATELAPGTGPVIGMTMCERAVREIIDSESSYVKDLGQVIRGYLEDW 571

  Fly   572 KERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPE 636
            ||||||:.|:|::||:||:|:|:||..||.||.....||..|:.|||||...|..||||||||||
Mosquito   572 KERACLKHDQLKVLFSNIQEVYDFNFKLLNRLREAKGDPVTISNCFIDLHAEFCCYTTYCTSYPE 636

  Fly   637 AISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKEVVEAH 701
            ||||||.|||||||.:||.||||:|:|.||||||||||||||||||||||:|||||:.::|..||
Mosquito   637 AISLLTTLLQATHTNALLVSTQKMLKHTLPLGSYLLKPVQRILKYHLLLDNLRKHCNDQQVALAH 701

  Fly   702 VIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQRLVLLFAT 766
            .:|::|||||||||.|.:|...||||:|||||||||:|:|||:|..||.|:| |:|.|:||||.|
Mosquito   702 ELMKKVAHNIDQVKTKLDQARLVKELAGILDGWLGPDLSVLGDLLHEGRLLE-HSKPRIVLLFQT 765

  Fly   767 MLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQH 831
            ||||.|.|||.||||:.||...||||.|||||||..|.|||||:|:..::||||||::||||||.
Mosquito   766 MLIIAKPKEDKRLQFRAYIPCKNLMLVEHLPGEPVCFRVIPFDDPKGALQLTARNREEKRIWTQQ 830

  Fly   832 IKGVMLEKL-DIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNS-TPTYLERRNACRRSEIRQ 894
            ||..||:.. |||.||.|||.|||:|::|..|:..||   ...:|| .|.|||||...||||:|.
Mosquito   831 IKKAMLQHYSDIPTRAMELVLQLGDEDERFTDKQYWK---RPANNSPIPEYLERRQQFRRSEMRM 892

  Fly   895 RNSKFKRKTVANSS------------SFDSFNESLEQEEESISQAKPSKPLARNNSLDDTALQKL 947
            |:.|...|..|:::            ||.|::..||....::|.:                    
Mosquito   893 RSKKNLLKKDASAAAVPPSVNGLSGPSFRSYSSDLESVPPAVSSS-------------------- 937

  Fly   948 AAAMRYRKRDAAVKEETKTPVKEPCKCDQDAKQ-DERI--EPCSCILRDQRSRSAKSQSPVFSYK 1009
                         .:..::|..|.||||...:| .|.|  .|.    :|..:.:....||.....
Mosquito   938 -------------NQRHESPSNEDCKCDAVKRQLQEEIINRPA----KDATTTAGSKTSPPPPKP 985

  Fly  1010 ALKERSKSVPRIGGFSLDEEAER----EREQDEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHK 1070
            |   ||:|..|.|  ..|:|.||    ..|:.:.||.:.||:|        ..:.|..::.||..
Mosquito   986 A---RSRSETRCG--PADDEEERLLKSLYERRKLSAPTKRGAK--------MKESFASIRSYNST 1037

  Fly  1071 TMPKKIANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVLKITESTEELRPDGEIELAQ----EAAT 1131
            .:||:|::::|:|..|..|.|.||.||              |.:.|.....:.|:|.    :.||
Mosquito  1038 MIPKRISDIRKRRPKTLTSSSTFYTDL--------------EISSETNATTDHEIADTSIGDRAT 1088

  Fly  1132 LDES---TQDQYYSPDHETELLSPAEKS-----------KRDAQIVLDLLKNSKEFERIYNKQQK 1182
            .||:   |.......|.:|.... ||.|           |:|.:|:..|:.:.::|.::.||...
Mosquito  1089 SDETVVQTVTTAMEQDCQTAACR-AESSAGGDGSGSMEPKKDCEIISQLILDVEQFNKVLNKPVT 1152

  Fly  1183 RRES--------PVSPVSPDISRGPILPPPRPPSRSPPPLE-----LEEQEKK----PVEEVDSV 1230
            :::|        |.:.:|..       ..|.|||..||..|     .:::|.|    .|....|.
Mosquito  1153 KKKSFDASSCSRPTALLSSQ-------RKPEPPSTEPPCDEDDDGGAQDEESKLQTSTVTLSGSD 1210

  Fly  1231 SEEPIYETLLRNVHVPYKFSP--------VLGRAKSSQILKKRSKTAP---------AASRPESD 1278
            ..|||||:||||||||||::|        ..|....|......:.:.|         ..:|||||
Mosquito  1211 EAEPIYESLLRNVHVPYKYAPPSLARHSLPCGEGGCSSSSNSGTGSCPKLLADDLAIRRTRPESD 1275

  Fly  1279 YVTLVYSPEGVLQRVGEEVVQ----------------RDSCSSSTTSTSSNG------------- 1314
            ||||.||..|:|:.:..|..:                |:|.::.:....:||             
Mosquito  1276 YVTLAYSELGLLEGIAAEDARSLQVKSSSQHITPQLLRNSDTNISYHRDNNGQQGKESDDDVEKL 1340

  Fly  1315 --------------SGSTLKRDSQSTVINLLMEAAQEHESRPLPKNSVSGSESSLLPRALKSIDN 1365
                          ||..|.......|..::.::..|.:.....||:   ::.|:|.|.: |:.:
Mosquito  1341 AMHHHHHQPPTSPSSGGDLSAQGSEKVTVVMKQSFLERQGSLSMKNT---AQKSILQRFI-SLHS 1401

  Fly  1366 LSMAFGRSNRPPE---------RRVSDVSEMCRQSVLHRQGSEAVGERMAHVDYADPKALF---- 1417
            .|.:.|......|         |::|:.:.  ....:::|||..:|.|:||:||||||.||    
Mosquito  1402 TSSSTGGGTMGSEGNLLLHSLQRKLSEPNG--SGGAIYKQGSMDLGSRIAHLDYADPKTLFFPPS 1464

  Fly  1418 --------------GLG-------VLNHS---------------ERDSVFSLTSSSSDSMCEQQR 1446
                          |.|       ::|.:               :||||.: :||||||:|::..
Mosquito  1465 APSSASSVTTLSMGGSGPTVNQNVLINRASMQSANGSNGSNDAQQRDSVLA-SSSSSDSVCDEHA 1528

  Fly  1447 KRSGVGATFE-----------------YEQQVEDSLENDFRDSAIYS-DDNEKR------SGDYD 1487
            ..:|......                 ||:.||:.||:||||||:|| |||:::      .|..|
Mosquito  1529 IPAGSSMNTTTTTTIAYDDDDDERCCFYERTVEECLEHDFRDSAVYSGDDNDRQQQQRVNGGGID 1593

  Fly  1488 -VHLRRPSSPPPPPPPLGPRPHQ----------------------PPQIAPKPSKDQLIQQRSGV 1529
             .||....:|...|    ||..|                      ||.|..||:...|:::.:..
Mosquito  1594 HQHLYEALTPIASP----PRAKQPGDQAALNGGDSGGGQQRNSAAPPPIPAKPAHLGLVKRPTSA 1654

  Fly  1530 IVCQSA----------------SRSWVLQQIENF 1547
            :...:.                ||.|||||:..|
Mosquito  1655 VSATTPTSPTNPTATTGTGTNNSRGWVLQQVRRF 1688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GEFmesoNP_788403.2 RhoGEF 548..712 CDD:459876 113/163 (69%)
PH_PLEKHG1_G2_G3 694..839 CDD:270063 93/144 (65%)
GEFmesoXP_061519316.1 None

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