Protein Alignment GEFmeso and MCF2

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_005262470.1
• Gene: MCF2 / 4168
• HGNCID: 6940
• Length: 1044
• Species: Homo sapiens
• Alignment Length: 822
• Identity: 172/822 - (20%)
• Similarity: 299/822 - (36%)
• Gaps: 238/822 - (28%)

  Fly   287 FDGHPFQGRKLTLPRY--------DSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATK 343
            |||. ::..:|.:.:|        |.||.:  .|:|.|....|:|           |..|.:..:
Human   306 FDGF-WEKHQLKMEQYLQLWKFEQDFQQLV--TEVEFLLNQQAEL-----------ADVTGTIAQ 356

  Fly   344 AKEFV---------CSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNK 399
            .|:.:         ..|.||....|......|.|.|...|.|     :..|...:..::..|||:
Human   357 VKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDL-----ICQRCNELRYLSDILVNE 416

  Fly   400 PLVRSSSAACASTICSSPLLTYAR------------------------TKSLGAKASTLGGGVPI 440
              :::.....:.|.....||..||                        .|:|....:.|...:|.
Human   417 --IKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMALPF 479

  Fly   441 KLPTAEQL---------AELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTS 496
            .....|.|         .||:...|.....|:.:..|.....|....||..:.||:  ..:..|.
Human   480 INYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHVRPI--QFVVPTP 542

  Fly   497 SSSSSGSDQLLNGKLMATSY---------LASVESLAESENELGDQHHPP--------------- 537
            .:..:......:.|.:...|         ....::..::::.|..:..|.
Human   543 ENLVTSGTPFFSSKQVGVGYSFFQACKLFSKGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDN 607

  Fly   538 --AMSVLEKTCL-EIVDSERSFVEDLGQVIKGYLQDWKERACLRVDEL------------QILFA 587
              ::.||:...| |::.:||.:|.:|..|:.||      ||.:...|:            .|||.
Human   608 GNSLDVLKNHVLNELIQTERVYVRELYTVLLGY------RAEMDNPEMFDLMPPLLRNKKDILFG 666

  Fly   588 NIEEIYEF-NSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTY 651
            |:.||||| |.:.|..|.|....|.|:..||::.:|.|.:|..||.:.|.:.::..|..:.
Human   667 NMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSEC---- 727

  Fly   652 SLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKH---CD----VKEVVEAHV-IMRQVA 708
            :.....|:.|:|||.|.||||||||||.||.|||..|.|:   |:    :|:.::|.: :::.|.
Human   728 AFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVN 792

  Fly   709 HNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEG--LLMEQHNK-------------- 757
            .::.|:               .::|::| .|..||::..:|  .:...|.|
Human   793 DSMHQI---------------AINGYIG-NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPM 841

  Fly   758 QRLVLLFATMLIITKQK-EDGR-------LQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQ 814
            ||.:.|:...::..|:: |.|.       ..||.....:.:.::|::.|:...| .|.:.|....
Human   842 QRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKF-EIWYGEKEEV 905

  Fly   815 IKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPT 879
            ..:.|.|.|.|..|.:.|:.::|::.::      |..:...::|:..:|
Human   906 YIVQASNVDVKMTWLKEIRNILLKQQEL------LTVKKRKQQDQLTER---------------- 948

  Fly   880 YLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKPLARNNSLDDTAL 944
                                           |.|..||:|.:|        |......|.::|.|
Human   949 -------------------------------DKFQISLQQNDE--------KQQGAFISTEETEL 974

  Fly   945 QKLAAAMRYRKRDAAVKEETKTPVKEPCKCDQDAKQDERIEP 986
            :..:..:...:..|:|:.|..|...|   ..|.|:..|  ||
Human   975 EHTSTVVEVCEAIASVQAEANTVWTE---ASQSAEISE--EP 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	62/184 (34%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	32/169 (19%)
MCF2	XP_005262470.1	SEC14	48..188	CDD:214706
		SPEC	328..519	CDD:238103	40/210 (19%)
		RhoGEF	615..792	CDD:238091	62/186 (33%)
		PH-like	799..930	CDD:473070	28/132 (21%)