Protein Alignment GEFmeso and CG46491

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Alignment Length: 818
• Identity: 155/818 - (18%)
• Similarity: 289/818 - (35%)
• Gaps: 269/818 - (32%)

  Fly   131 RLVQRRSQESQIHGS---SSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEA----- 187
            |.:..::.|.:.|.|   ||::.|:..:|..|::...|         |.||...:|:::.
  Fly    29 RRISHQAAEQERHSSTLVSSNLESNDVARPVSSVSSSS---------SSIQLSYSVNSDTDSSYR 84

  Fly   188 ----LKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSAPKLKLSHIPLSKITGKLSTQSGSELVSTF 248
                ||.|:.:|           .|..||.    |.|:     .|:|..|...:.....:.|..|
  Fly    85 HRSLLKMHEAES-----------VGGLGTE----STPE-----SPMSPQTPDPALLDVRQKVHRF 129

  Fly   249 DSSNEYLNSVAFAAFEKSK---------PQDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDS 304
            ::   :..::.|...|:..         |..||::..:.:.|.||         .|::.||...|
  Fly   130 EA---FRTNICFIKQERHSLKLLENRRHPSFEDQSEDHHTPPATP---------PRRIRLPGLGS 182

  Fly   305 QQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQ 369
            :.|.:...:....| ....:.::..........|.|.|.|:|::         :|||
  Fly   183 RGSSRSSSIPSFQA-GIHEVRSEDEVDQISDFETDSHTAAEEYL---------VVDT-------- 229

  Fly   370 HMERLTLADPGDLDPRAELI--EAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKAS 432
                           .:|::  |.|..:.|::..|:.|.:|..|                 .:|.
  Fly   230 ---------------TSEVVPSEEVADSKVDQQQVQRSISADQS-----------------KEAL 262

  Fly   433 TLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSS 497
            ||    |:|:                                       .|:.|.:..|.....:
  Fly   263 TL----PLKM---------------------------------------RNDFPRNYRSTPRRKT 284

  Fly   498 SSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQ 562
            .....:::.|.||..:.......|.  |.|.||.|:.......:||    |::.:|.::|.:|..
  Fly   285 EIIGTTNEHLVGKFHSVYQPKDEEE--EVEIELRDKSDKCVHPILE----ELIKTEEAYVNNLFT 343

  Fly   563 VIKGYLQDWKERACLRVDELQI--------LFANIEEIYEFN-SMLLQRLINTGRDPGRIARCFI 618
            .|:.|...::.:      :|.:        ||.|||:|.||: ...|..|....||..|:...|:
  Fly   344 GIENYGNIFQRK------DLPLGLRGKKYDLFGNIEQIAEFHRDEFLPMLQRNRRDLKRLFDEFL 402

  Fly   619 DLRD-----GFDVYTTYCTSYPEAISLLTKLLQATHTY-SLLASTQKLLQHRLPLGSYLLKPVQR 677
            ...|     |:.::|..          ..|.|:....| :...|.:.....:|.:.|:|::|:||
  Fly   403 QFLDQHCFYGYVIFTMN----------KQKSLKLCDLYKNYFTSIRLERDDKLGINSFLVQPIQR 457

  Fly   678 ILKYHLLL----DSLRKHCDVKEVVEAHVIMRQVAHNIDQVKRK------QEQQSRVKELSGILD 732
            :.:|.|||    ::..|:.|        ::|:.:..:..:::::      ...:|.:  ::.|:|
  Fly   458 MARYPLLLTQFINTFFKNRD--------IVMKPLIESCCRLEKRLRALLTTTNESEI--INDIVD 512

  Fly   733 GWLGPELTVL--GELRQ--EGLLMEQHNKQRL---VLLFATMLIITKQKEDGRLQFKTYISQNNL 790
               ..|..|.  |:.|:  |..:::...|:..   |.:|...:|.|:            |...||
  Fly   513 ---CHEFNVYYQGKFRKVNEFQVLDHKLKRSYRSKVFIFDKCIIYTE------------IKGKNL 562

  Fly   791 MLSEHLPGE------PTSFYVIPFDEPRHQ-IKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKE 848
            :.....|.|      .|..:.:.::..:.| .:.|| :..|..||           ||:   .::
  Fly   563 LFHGRYPCEHIGISAKTKSFTLYYERRKQQECEFTA-DPVQIAIW-----------LDL---IRD 612

  Fly   849 LVYQLGNEE--------DRTPD---RSTWKWSLHSGSN 875
            ::....|||        .|..|   |....:||:..||
  Fly   613 MINNYANEERQKLQERYSRENDHLHRKAPSFSLYRDSN 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	41/182 (23%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	26/164 (16%)
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	40/162 (25%)
		ROM1	<438..>660	CDD:227709	50/253 (20%)