Protein Alignment GEFmeso and CG30440

DIOPT Version :9

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Alignment Length: 1163
• Identity: 237/1163 - (20%)
• Similarity: 411/1163 - (35%)
• Gaps: 368/1163 - (31%)

  Fly     3 IESDSDTSERWEDFFGSSTELAPSLLGIYDTLTNSFAAGGVA-----AAPTATSHESKAS----- 57
            :|.||||.        :||.:....|    .:|:....|..|     :.|...:..:|.:
  Fly    13 MEEDSDTR--------NSTYVPKMEL----LMTHYIHEGKKAIMYRSSEPQIAARRNKKTRFVGN 65

  Fly    58 -------SSGDSTPKRSNSNCSSSSSTGSSTGS-------------CSSVPTSDDQSASYTLASS 102
                   |..:::.|.|.|.|..::.|.....|             .|.:...:|.|.|..|.::
  Fly    66 RRQLRNLSQPENSHKTSRSLCPDTAKTEPKVYSLRFVLNKSEDKDYMSRLKAQNDFSQSSCLCNN 130

  Fly   103 STHLGHQEPPA---PLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGSSRRGSNIR-- 162
            .:| .:.|..|   ..::.|.||..|....:..:|.|:..      .:.|.:.|.  |.::::
  Fly   131 LSH-ANTEAGAYQNDGILKGQRDHSDFLTAAGGIQSRADR------IARIETCGI--RTTHLQPE 186

  Fly   163 ------ILSPNVHRIITHS-----------DIQPVEAVSAEALKQHQQQSQRSPTQ--GR----- 203
                  :..||..|...||           |:.....:||       ..|:..|.:  ||
  Fly   187 TQILKPVTEPNETRFDQHSPDWLFKNSRIGDVSNSSKLSA-------CNSELPPEEYKGRTLYHD 244

  Fly   204 ------YIKTGHSGTPPAAGSAPKLKLSHI--PLSKITGKLSTQSGSELVSTFDSSNEYLNSVAF 260
                  |||...    |...:..|:.::..  |.:|.|..........:......:..:||.|
  Fly   245 TKFDCAYIKNRR----PLITTESKMSITEAEHPQTKYTDIKYDYKTCSISQGLHQNKAFLNKV-- 303

  Fly   261 AAFEKSKPQDEDRTPTNKSVPGTPFHFDGHPFQG--RKLTLPRYDSQQSIK----------LIEM 313
                          |.:|.  ..|||...:.:..  :||.|.: :|::.|:          .::.
  Fly   304 --------------PPSKQ--SKPFHSVDYDYYENIQKLHLSK-ESERQIRDNGDPNDLQNFLKK 351

  Fly   314 EQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLAD 378
            ..:.||:.:||.|             :|...|:  |:     :|:...:| ||..:. |..|..|
  Fly   352 NLIKATTNELLKA-------------AAQSTKK--CN-----IDLERKLN-DLNIKE-EDHTSND 394

  Fly   379 PGDL---DPRAELIEAVN----------------------------KTLVNKPLVRSSSAACAST 412
            .|:.   ||....:..:|                            |:.:.:.:...|||:.:.:
  Fly   395 SGNSYKNDPYLVSMSKINSCKFIRSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLS 459

  Fly   413 ICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEE-------ANKLSAESLDRLTDIKP 470
            .|....|.         |.|..|        :.|...|..|       .|:||.:.|:
  Fly   460 SCDGSCLN---------KDSICG--------SEEDCCECNEYQCIATPPNELSKDCLN------- 500

  Fly   471 KFAARLSELARLN------NRPLSSSSICSTS------------------------SSSSSGSDQ 505
                .:.|....|      :..|:||..||.|                        |...||:|:
  Fly   501 ----AVEEGVFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSLHESGTDE 561

  Fly   506 LLNGKLMATSYLASVESLAESENELGD-----------QHHPPAMSVLEK-------------TC 546
            .|:.|   |..||..|...:....:.|           .|.|.:..:.:|             ..
  Fly   562 KLSRK---TILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHIL 623

  Fly   547 LEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDE-----LQ----ILFANIEEIYEF-NSMLLQ 601
            .|:.::|:.:|.::..::|||...      |:.||     ||    :||.|:.|||.| |.:.|:
  Fly   624 KELFETEKIYVNEIASILKGYYDR------LKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLK 682

  Fly   602 RLINTGRDPGRIARCFIDLRDGF-DVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRL 665
            .|.|......|:|.||:..||.| .:|:.||.:...:..|...|:.   |:......|..|.|:|
  Fly   683 DLENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVD---THMFFKECQIGLGHKL 744

  Fly   666 PLGSYLLKPVQRILKYHLLL---------DSLRKHCDVKEVVEAH-VIMRQVAHNIDQVKRKQEQ 720
            |||:|||||||||.||.|||         ||.|.  ::|..::.. ::::.|..::.|:.
  Fly   745 PLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRN--ELKNALDCMLIVLKCVNDSMHQIS----- 802

  Fly   721 QSRVKELSGILDGWLGPELTVLGEL-----------RQEGLLMEQHNKQRLVLLFATMLIITKQK 774
                      :.|:.| :|...|||           .::.:.:....|:|.:.|:...|::.||.
  Fly   803 ----------ITGFSG-DLAKQGELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQT 856

  Fly   775 -----EDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQI-KLTARNRDQKRIWTQHIK 833
                 .....|||:.:..:.:.|:|.:.|:...|.|  :.:.|.:: .|.|.....|.:|...||
  Fly   857 SKSGYNKSSYQFKSDVKMSQIGLTESVSGDAKRFEV--WLKGRQEVYTLQASTIGVKEMWVAEIK 919

  Fly   834 GVMLEKLDIPMRAKELV-YQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNAC---------R 888
            .|:..:|: .::..::. |.:.::       |.|:.|.....|.|...| ||..|         |
  Fly   920 RVLFNQLE-KLKGDQIARYNIRHQ-------SLWQKSSCEAPNITHCSL-RRTECFELPLNDSNR 975

  Fly   889 RSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKPLARNNSLDDTALQK 946
            .:.||...:....:.:.|       ..|::.:.|..|.:.....:..:.:::...:||
  Fly   976 NTNIRSEKTCLSDQNIVN-------GPSVQDQHEKNSWSSDCSDIDEDETINPILMQK 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	61/185 (33%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	31/162 (19%)
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	61/184 (33%)
		PH-like	802..925	CDD:302622	28/140 (20%)
		PH	829..922	CDD:278594	21/94 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840