Protein Alignment GEFmeso and Plekhg4

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_038954139.1
• Gene: Plekhg4 / 307796
• RGDID: 1310790
• Length: 1231
• Species: Rattus norvegicus
• Alignment Length: 1366
• Identity: 250/1366 - (18%)
• Similarity: 415/1366 - (30%)
• Gaps: 525/1366 - (38%)

  Fly    40 AGG----VAAAPTATSHESKASSSGDSTPKRSNSNCSSSSSTGSSTGS----------------- 83
            :||    :..||.|.|.|...|       :..|..|..||....:.|.
  Rat    83 SGGNQRSILGAPQAQSEEPAFS-------EMENCLCPGSSHLNLTQGENDHRGGGLIGDPEPGRA 140

  Fly    84 -----------CSSVPTSDDQSASYTLASSSTHLGHQEPPAP------------LVVAGLRDEPD 125
                       .|.:|.:|...:|:              |.|            |:.:|:...|
  Rat   141 LPAGFSPLLEMSSKLPEADPSGSSF--------------PRPADCLLARDLTWELLASGMAALP- 190

  Fly   126 GAQLSRLVQRRS--QESQIHGSSSSIASSGS-SRRGSNIRIL---SP-------NVHRI------ 171
             ..|..|::.|.  .:::||    |:.|:|: ...|..:.:|   ||       |.|.:
  Rat   191 -GSLGGLMRWRKWPGKARIH----SLLSTGTRDIEGRAVLLLCAHSPAWLHPKCNSHELLSLLFY 250

  Fly   172 ---ITHSDIQ-------------PVEAVSAEALKQHQQQSQRSPTQ----GRYIKTGHSGTPPAA 216
               |...::|             |..:.....|.|.|:.|..|..|    |:..:....|.....
  Rat   251 LRGIPRPEVQALGLTVLVDARICPPSSALTWGLSQLQEASPGSVQQLLLVGKMPEDMPVGLQAKQ 315

  Fly   217 GSAPKLKLSHIPLSKITGKLSTQSGSEL-------------VSTFDSSNEYLNSVAFAAFEKSKP 268
            .::.:..|:|||    ..:|.|..|..|             :.|...|.:...::.....:..|.
  Rat   316 LASHQSLLTHIP----NMELPTSLGGCLSYCHQAWLDFRMRLETLQQSCQVACALLQGVIDSMKA 376

  Fly   269 QDEDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAAT-SAQLLHAKPATPG 332
            .   |.|......|....      |.:.|      .||.::..::..|.:. |.:|...|...|.
  Rat   377 M---RQPLESGEVGELLQ------QAQSL------MQQVLESPQLSWLQSQGSLELAWLKQGMPQ 426

  Fly   333 TPATPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLT---------------------- 375
            ...:|             :..|.||..|.: :..|.:.:.|||
  Rat   427 VALSP-------------DYRSAVDKADEL-YGQVDELLHRLTLKSNQRIRALELLQALEAQEGV 477

  Fly   376 ---------------LADPGD--LD-------PRAEL-------IEAVNKTLVNKPLVRSSSAAC 409
                           |.:||:  ||       |..||       ::...|.|  :|||...:|..
  Rat   478 LCQIEVWLQEVGWPGLEEPGEPSLDMLLQAQGPFQELDLVAQEQVKQGEKLL--QPLVGWEAAEL 540

  Fly   410 AST-----ICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAEL--------EEANKLSAE- 460
            ..|     ...|.|:.::|  :|..:..        :|..||:|.:.        ||..::..|
  Rat   541 GPTGKRFLALRSQLMEFSR--ALAQRRQ--------RLADAEKLFQFFKQASTWTEEGQRVLTEL 595

  Fly   461 -------SLDRL-------TDIKPKFAARLSELA---------------------------RLNN 484
                   .|.||       .|:.|....::..||                           :...
  Rat   596 EQETPEVVLQRLQLHWSKHPDLPPAHFRKMWALATGLGSEGIRQECRWAWAQCQDTWLALDQKRE 660

  Fly   485 RPLSSSSICSTSS---------------SSSSGSDQLLNGKLMATSYLASVESLAESENELGDQH 534
            ..|...|:.||::               ..|...||.| ||     :|....:.......:.|.|
  Rat   661 AALKPQSMNSTATLYVRRAPAIPTIPPLRKSYSFDQNL-GK-----HLGDASNRGHCAATVTDCH 719

  Fly   535 HPPAM---------SV-------------LEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACL 577
            .|.|.         ||             |:....|:|.:||.:|..|...|:.|..:
  Rat   720 RPEARGGIRPRSSPSVPLSGSSDFRSPNRLQLVLAEMVATEREYVRALDYTIQNYFPE------- 777

  Fly   578 RVDELQI----------LFANIEEIYEFN-SMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYC 631
             :|...:          ||.|:|::.:|: ...|:.|....|.|.|:|..|:..|..|.:|..|.
  Rat   778 -LDRSDVPQGLRGQRAHLFGNLEKLRDFHFHFFLRELEACTRHPPRVAHAFLRHRVQFGMYALYS 841

  Fly   632 TSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC---- 692
            .:.|.:.:|::..   .||:  ....|:.|...|.|.||||||:||:.||.|||..|.:.|
  Rat   842 KNKPRSDALMSNY---GHTF--FKEKQQALGDHLDLASYLLKPIQRMSKYALLLQELARACGGPA 901

  Fly   693 -DVKEVVEAHVIMR-QVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQ- 754
             ::..:..|..::. |:.|..|.:               .:|...|.::    .|:::|.|:.|
  Rat   902 QELGALQAAQSLVHFQLRHGNDLL---------------AMDAIQGCDV----NLKEQGQLVRQD 947

  Fly   755 --------HNKQRLVLLFATMLIITKQKEDGR----LQFKTYISQNNLMLSEHLPGEPTSFYVIP 807
                    |...|.|.||..:|:.:|.:....    ..:|......:|.|:| ..||....:.|.
  Rat   948 EFTVRAGHHKSCRRVFLFEELLLFSKPRRGPAGVDIFTYKRSFKMADLGLTE-CCGESKLRFEIW 1011

  Fly   808 F--DEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSL 870
            |  .:.|....|.|.:...|:.||..|                             .|..|:.::
  Rat  1012 FRRRKARDLFVLQASDVATKQAWTADI-----------------------------SRLLWRQAV 1047

  Fly   871 HSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKPLAR 935
            |:                 .|:|.  ::.....|.|.:.:|     :...||:|:....:..|.|
  Rat  1048 HN-----------------KEVRM--AEMASMGVGNKAFWD-----IAPSEEAINDRNINYVLKR 1088

  Fly   936 NNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVKEPCKCDQDAKQDERIEPCSCILRDQRSRSAK 1000
                                                                    ||.|||::.
  Rat  1089 --------------------------------------------------------RDVRSRASI 1097

  Fly  1001 SQSPVFSY--------KALKERSKSVPRIGGFSL--------------------DEEAEREREQD 1037
            :.:| |.|        .:|.....|...:|..:|                    .|||..:.|.|
  Rat  1098 AVAP-FDYDNPYLGALASLPGDRASCSVLGSLNLHLYRDPALLGVHWSLLPPNFPEEASLDTEVD 1161

  Fly  1038 EDSAASLRGSKPDLSER--KTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSCSRFYMDLSEF 1100
            ..|..||.....::|.:  ...|....:....:.:||.:.:.:|..:.::.......::.:..|.
  Rat  1162 LGSQPSLTPEDSEVSSQCPSASGSSGSDSSCVSGQTMGRGLEDLSCETTTLDSGHPCYFQESEEM 1226

  Fly  1101 D 1101
            |
  Rat  1227 D 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	51/180 (28%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	32/160 (20%)
Plekhg4	XP_038954139.1	DUF3584	<376..>596	CDD:432349	47/260 (18%)
		RhoGEF	749..915	CDD:238091	50/178 (28%)
		PH_puratrophin-1	915..1050	CDD:270062	34/200 (17%)