Protein Alignment GEFmeso and Vav3

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_017446264.1
• Gene: Vav3 / 295378
• RGDID: 1565941
• Length: 875
• Species: Rattus norvegicus
• Alignment Length: 817
• Identity: 170/817 - (20%)
• Similarity: 302/817 - (36%)
• Gaps: 193/817 - (23%)

  Fly   402 VRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLT 466
            :|:..|||..|              .|.|.|.|                        .|:.| |.
  Rat    75 IRTFLAACCDT--------------FGMKKSEL------------------------FEAFD-LF 100

  Fly   467 DIKPKFAARLSELARLNNRPLS-SSSICSTSSSSSSGSDQLLNG--KLMATSYLASVESLAE--- 525
            |:: .|...:..|:||:..|:: ::.|....:..|...:.:..|  .|:..:.:...|.|.:
  Rat   101 DVR-DFGKVIETLSRLSRTPIALATGIRPFPTEESVNDEDIYKGLPDLIDETRVEDEEDLYDCVY 164

  Fly   526 SENELG----------DQHHPPAM-SVLEKTCL-EIVDSERSFVEDLGQVIKGYLQDWKERACLR 578
            .|:|.|          :.|...:. :.:...|| ||..:|..:.|.|..:.|.::...|.  .|.
  Rat   165 GEDEGGEVYEDLMKAEEAHQAKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMAPLKR--FLT 227

  Fly   579 VDELQILFANIEEIYEFNSMLLQRLINT--GRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLL 641
            ..|...:|.||.::.:.:..|:|.:.::  .:|...:.:.||:.::...:|..||:....|||.|
  Rat   228 AAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDHNLYQVFINYKERLVIYGQYCSGVESAISSL 292

  Fly   642 TKLLQATHTYSL-LASTQKLLQH-RLPLGSYLLKPVQRILKYHLLLDSLRKH-------CDVKEV 697
            ..:.:......| |....|...: :..|...|:.|:||:|||||||..|.||       .::|..
  Rat   293 DYISKTKEDVRLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTHDPMEKSNLKLA 357

  Fly   698 VEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLL----MEQHNKQ 758
            ::|   |:.:|..:::|||..|....:|:....::. |...:.:.|..:.:|.:    :::|.||
  Rat   358 LDA---MKDLAQYVNEVKRDNETLREIKQFQLSIEN-LNQPVLLFGRPQGDGEIRITTLDKHTKQ 418

  Fly   759 -RLVLLFATMLIITKQKEDGR-----LQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKL 817
             |.:.||...:|:.|:|.|..     :..:.|...||....:........||:| ..:.::.::.
  Rat   419 ERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLI-HTQGQNGLEF 482

  Fly   818 TARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLE 882
            ..:.:|.|:.|        ||:.::         .|.|......|.:...:.:|:        ..
  Rat   483 YCKTKDLKKKW--------LEQFEM---------ALSNIRPDYADSNFHDFKMHT--------FT 522

  Fly   883 RRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEE-----ESISQAKPSKPLARNNSLD-- 940
            |..:||..::..|.: |.:..:.......:..|.|.:.:     .|:.|.....|..|.|.|.
  Rat   523 RVTSCRVCQMLLRGT-FYQGYLCFKCGAKAHKECLGRVDNCGRVNSVEQGPFKPPEKRTNGLRRA 586

  Fly   941 ----DTALQKLAAAMRYRKRDAAVKEETKTPVKEPCKCDQ----DAKQDERIEPCSCILRD---- 993
                |..|.|:.....|          |.||   |....:    ..:..:.:|    :||.
  Rat   587 SRQVDPGLPKMRVIRNY----------TGTP---PPALHEGPPLHIQAGDTVE----LLRGEAHT 634

  Fly   994 ---QRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDE--EAEREREQDEDSAASLRGSKPDLSE 1053
               |....|..:...|...|:|. |..||:...:|...  ....||.|.|....: |.:...|..
  Rat   635 VFWQGRNLASGEVGFFPSDAVKP-SPCVPKPVDYSCQPWYAGPMERLQAETELIN-RVNSTYLVR 697

  Fly  1054 RKTKGKGFFEVK-QYNHKTMPKK---------IANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVL 1108
            .:||..|.:.:. :||::....|         ||..:|.:|         .|:|.|:....|
  Rat   698 LRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKS---------LMELVEYYKHHS--- 750

  Fly  1109 KITESTEELRPDGEIELAQEAATLDESTQDQYYSPDH 1145
                            |.:...|||.:.|..|..|:|
  Rat   751 ----------------LKEGFRTLDTTLQFPYKEPEH 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	46/174 (26%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	32/154 (21%)
Vav3	XP_017446264.1	CH_VAV3	2..118	CDD:409113	17/82 (21%)
		RhoGEF	193..369	CDD:238091	48/180 (27%)
		PH_Vav	383..506	CDD:269930	26/141 (18%)
		C1_VAV3	506..564	CDD:410419	9/66 (14%)
		SH3_VAV3_1	596..657	CDD:212914	13/77 (17%)
		SH2_Vav3	666..768	CDD:198270	27/130 (21%)
		SH3_VAV3_2	819..874	CDD:212911