Protein Alignment GEFmeso and TIAM2

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_036586.3
• Gene: TIAM2 / 26230
• HGNCID: 11806
• Length: 1701
• Species: Homo sapiens
• Alignment Length: 1239
• Identity: 262/1239 - (21%)
• Similarity: 434/1239 - (35%)
• Gaps: 364/1239 - (29%)

  Fly   132 LVQRRSQ---ESQIHGSSSSIASSGSSRRG--SNIRILSPNVHRIITHSDIQPVEAVSAE----- 186
            |.|..||   |:.:....|:.||..:.:.|  ..:|:|......::...|:.......||
Human   599 LFQATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQLSV 663

  Fly   187 --------ALKQHQQQSQRSPTQGR--------YIKTGHSGTPP------AAGSAP-KLKLSHIP 228
                    |::...||.:::..:..        |:.:...|..|      ||.|.| ||.|..:
Human   664 VSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPSKLALGRL- 727

  Fly   229 LSKITGKLSTQSGSELVSTFD----------------------SSNEYLNSVAFAAFEKSKPQ-- 269
                 |.||..|...||.:.|                      ||.:.|:::|....|| :|.
Human   728 -----GILSVSSFHALVCSRDDSALRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKEK-RPSIT 786

  Fly   270 --DEDRTPTNKSVPGTP----------FHF-DGHPFQ-GRKLTLPRYDSQQSIKL-IEMEQLAAT 319
              ||.......:|.|.|          .|| |.|... |.|   |.:..:..:.| .:|.||..:
Human   787 QVDELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIK---PEHRVEDILTLACKMRQLEPS 848

  Fly   320 SAQLLHAKPATPGTP-ATPTPSATKAKEFVCSEPLSPVDIVDT----------INFDLVA----- 368
            ...|...|....... ..|.|.....::......:.|:::.|.          ..|.:.|
Human   849 HYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVCDFGFAVTAQVDER 913

  Fly   369 QHMERLTLAD-------------------------PGDLD-PRAELI---EAVNKTLVNKPLVRS 404
            ||:.|:.::|                         ..||| .:.|.:   ::|..||:.:|   .
Human   914 QHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEALFSEKSVGLTLIARP---P 975

  Fly   405 SSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAE--LEEANKLSAESLDRLTD 467
            .:.|...|..|...|.....|||            :..|...||.|  |:...|.:|.....:.|
Human   976 DTKATLCTSWSDSDLFSRDQKSL------------LPPPNQSQLLEEFLDNFKKNTANDFSNVPD 1028

  Fly   468 IKP--KFAARLSELARLNNRPLSSSSICSTSSSSS---SGSDQLLNGKLMATSYLASVESLAESE 527
            |..  |.:.....|.::::|.....:..|....::   |.:|...||          :|...|::
Human  1029 ITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANG----------MEGPRENQ 1083

  Fly   528 NELGDQHHPPAMSV---------LEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQ 583
            :       ||..|:         |.|...|:||:|:|:|:||..:.:.||:..:....|..||::
Human  1084 D-------PPPRSLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEME 1141

  Fly   584 ILFANIEEIYEFNSMLLQRL---------INTGRDPGRIAR-------CFIDLRDGFDVYTTYCT 632
            .||.::.|:.||..:.|:.|         .||...|.:..:       .|:...|.|.:|:.:|.
Human  1142 SLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCA 1206

  Fly   633 SYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSL--------R 689
            ::.:...:|.:........:.|.:.....||...|.|||:|||||:|||.|||..|        .
Human  1207 NHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESE 1271

  Fly   690 KHCDVKEVVEAHVIMRQVAHNIDQVKR------------KQEQQSRVKELSGILDG--------- 733
            :|..:.|.::|   |.:||.:|:::::            ..||....||::.:..|
Human  1272 EHYHLTEALKA---MEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVS 1333

  Fly   734 WLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPG 798
            ||.|.|: ||:.|::..|.....|:.::|::         ||:.:|:.|  :..|:.........
Human  1334 WLNPFLS-LGKARKDLELTVFVFKRAVILVY---------KENCKLKKK--LPSNSRPAHNSTDL 1386

  Fly   799 EPTSF-YVIPFDEPRHQIKL-TARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQL--GNEEDR 859
            :|..| ::||..  ..|::| .....:...||.     ::..|.:|..| .|.::||  .:.|.:
Human  1387 DPFKFRWLIPIS--ALQVRLGNPAGTENNSIWE-----LIHTKSEIEGR-PETIFQLCCSDSESK 1443

  Fly   860 T----------------------PDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRK 902
            |                      |...|.|..|....|..|  :..:.|..||          .|
Human  1444 TNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVP--VSAKLASSRS----------LK 1496

  Fly   903 TVANSSSFDSFNES-----LEQEEESISQAKPSK--PLARNNSLDDTALQKLAAAMRYRKRDAAV 960
            .:.||||.:...|:     |:.:|.|:|....|.  |.|..                  ::|:..
Human  1497 VLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEG------------------RQDSKS 1543

  Fly   961 KEETKTP-----------VKEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKER 1014
            ....|.|           :||     .|...||         .|...::.|..||....:...:|
Human  1544 TSPGKYPHPGLADFADNLIKE-----SDILSDE---------DDDHRQTVKQGSPTKDIEIQFQR 1594

  Fly  1015 SKSVPRIGGFSLDEEAEREREQD---EDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKI 1076
            .:       .|.|.:...|.||.   |.......|.:|.|    .:|. |..:|        :|.
Human  1595 LR-------ISEDPDVHPEAEQQPGPESGEGQKGGEQPKL----VRGH-FCPIK--------RKA 1639

  Fly  1077 ANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVLKITESTEELRPDGEIELAQEAATLDESTQDQYY 1141
            .:.|:.|.:..|:..|.    ...||.|.      .:|.:|....|.|.:.::.|...|.:..|.
Human  1640 NSTKRDRGTLLKAQIRH----QSLDSQSE------NATIDLNSVLEREFSVQSLTSVVSEECFYE 1694

  Fly  1142 SPDH 1145
            :..|
Human  1695 TESH 1698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	54/187 (29%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	34/167 (20%)
TIAM2	NP_036586.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..250
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	265..293
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..417
		PH1_Tiam1_2	505..631	CDD:269937	9/31 (29%)
		Tiam_CC_Ex	645..742	CDD:408184	22/102 (22%)
		Ubl1_cv_Nsp3_N-like	811..881	CDD:475130	15/72 (21%)
		PDZ	887..976	CDD:214570	15/91 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1070..1092		8/38 (21%)
		RhoGEF	1103..1292	CDD:214619	55/191 (29%)
		PH2_Tiam1_2	1294..1466	CDD:269957	36/191 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1500..1556		15/73 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1568..1628		16/79 (20%)