DRSC/TRiP Functional Genomics Resources

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Protein Alignment GEFmeso and tiam-1

DIOPT Version :9

Sequence 1:NP_788403.2 Gene:GEFmeso / 37134 FlyBaseID:FBgn0050115 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_491367.3 Gene:tiam-1 / 259373 WormBaseID:WBGene00015704 Length:889 Species:Caenorhabditis elegans


Alignment Length:952 Identity:176/952 - (18%)
Similarity:307/952 - (32%) Gaps:390/952 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   218 SAPKLKLSH----------IPLSKITGKLS-------TQS---GSELVSTFDSS---NEYLNSVA 259
            |:|:|..:.          ||:.:...|:|       |:.   |...:|:.|:|   ::..|:.|
 Worm    57 SSPRLLATSSSGQVLLDTLIPMGEKVHKVSDFFVYLKTEGRTIGFNTLSSRDTSLLISQATNTTA 121

  Fly   260 F--------------AAFEKSKPQDEDRTPTNKSVPGTP----FHFDGHPFQGRKLTLPRYDSQQ 306
            |              |.||....|..|..|...:|...|    |::.|.|.:             
 Worm   122 FNMFQHSFSVSVSRIATFEGDSIQPCDEQPETSNVSLNPLNMVFNYKGSPVE------------- 173

  Fly   307 SIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVC-SEPLSPVDIVDTINF--DLVA 368
             |.|:|.                                 |.| ||..:.|||....|.  .:|:
 Worm   174 -IDLLEC---------------------------------FACSSEAENCVDIAHANNIFRVIVS 204

  Fly   369 QHMERLTLADPGDLDPRAELIEAVN-------KTLVNKPLVRSSSAACASTICSSPLLTYARTKS 426
            .|....             ||:|:|       :|..|  ||..:..|..:......|:....|..
 Worm   205 AHAHLF-------------LIQALNVSSLLLARTTSN--LVAINYLARQNDKIQQKLIALLETSE 254

  Fly   427 LGAKASTLGGGVPIKLPTAEQLAEL---------EEANKLSAESLDRLT----DIKPKFAARLSE 478
            ....||            .|.:.::         :..|.|...:|..:.    ||.|:...:|.|
 Worm   255 SSENAS------------KEDIRQMLLLKNVVVTQRLNSLQQRALPGIELIQHDISPQIDQKLLE 307

  Fly   479 LARL----------------------------------------------NNRPLSSSSI----- 492
            ..||                                              |..||.|..|     
 Worm   308 KCRLPSLFLYHFNMNSFRIWRKPMETRDMNTMGSSMASTSQYHQIPIQIQNQNPLPSQQIQPQQQ 372

  Fly   493 ------------------------------------CSTSSSS-----------------SSGSD 504
                                                ||.:.:|                 ||..|
 Worm   373 QQYHPPDHVTTHNGTTTFHTTNPTKPRLCEGSLAPGCSLAEASEQRKREMAEQKKELAGPSSAED 437

  Fly   505 QLL---NGKLMATSY------------------------------------LASVESLAESEN-- 528
            ..:   ||:|..|.|                                    ::||.:.::.|.  
 Worm   438 YFVRKTNGRLGLTIYAHNDDGVIRAEVRGVTSFAPRCAQVGDSVVAVDSELISSVRNASDVEKLL 502

  Fly   529 ELGDQHH--------PPAMSVLEKT-------CL-------EIVDSERSFVEDLGQVIKGYLQDW 571
            .:|...|        |.|.|.|:.|       |.       |::.:|:.:|.||.::.:.:|...
 Worm   503 RIGKVIHLRRKTPLTPRAPSQLDATNVNKKTGCAKLAMALQELLVTEKKYVSDLREMNEVFLCMR 567

  Fly   572 KER----ACLRVDELQILFANIEEIYEFNSMLLQRLINTG--RDP-GRIARCFIDLRDGFDVYTT 629
            :.|    |.:|:.::|..|  ::.|.|....:.::.|:..  ||. .|:...||:....|.:|..
 Worm   568 QVRDIMNAAIRLYKMQTSF--VDSIEEAIGDMSRQDISVAQIRDSVMRVCAVFINKCSDFKIYAE 630

  Fly   630 YCTSY-------PEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLL-- 685
            |...|       .....||:||       ..:.||::  || ....|.::||||||::|.|||  
 Worm   631 YAAGYHLLQHEIKNKKELLSKL-------EAVNSTRE--QH-CSWESRMIKPVQRIVQYPLLLKN 685

  Fly   686 --DSLRKHCDVKEVVEAHVIMRQV---AHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGEL 745
              |:|.|  |.:|.|:....::::   |..:::::|..|..::..|.....:..:..|.::..:.
 Worm   686 IADALPK--DARERVQVEAALQKMQTSAEYVNEMQRLHEDYAQYMETVRKANEPMLAEKSLRLDT 748

  Fly   746 RQEGLLMEQHNKQR-------LVLLFATMLII--TKQKEDGRLQFKTYISQNNLMLSEHLPGEPT 801
            |:  ||:..|.|.|       :|.:|.:::::  :..:::.::::...:..|.:.::| :|.:..
 Worm   749 RE--LLVFAHIKWRDAPAEHYVVFVFHSLILLLPSYARKEIKMKWTRVLPINEVDINE-MPNDAL 810

  Fly   802 S--FYVIPFDEPRHQIKLTARNR------DQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEED 858
            :  .|...|:.|..|:..:..|.      .|.::....||.:        .:|:.|.    :.|.
 Worm   811 NLKLYHAAFEGPNGQLSHSNPNTVYNIECCQSQLKQHLIKNI--------KKARTLF----SRES 863

  Fly   859 RTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEI--RQRNSK 898
            ..|        |...|.|...|:        ||:  ..||||
 Worm   864 HRP--------LSGSSQSDGGYV--------SEVSKEHRNSK 889

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GEFmesoNP_788403.2 RhoGEF 548..713 CDD:279015 49/185 (26%)
PH_PLEKHG1_G2_G3 694..839 CDD:270063 26/164 (16%)
tiam-1NP_491367.3 RhoGEF 541..715 CDD:238091 49/187 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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