DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GEFmeso and pex13

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_593611.1	Gene:	pex13 / 2543046	PomBaseID:	SPAC3C7.10	Length:	288	Species:	Schizosaccharomyces pombe

Alignment Length:	177	Identity:	34/177 - (19%)
Similarity:	59/177 - (33%)	Gaps:	65/177 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 NRPLSSSSICSTSSSSSSGSDQLLNGKLMA-----TSYLASVESLAESENELG------------ 531
            |.|:||..:..:...:.....|:|...|||     .::::..|:|.:.::.:|
pombe    79 NGPISSLQVIESIVGAVGSIAQVLESTLMAAHMSYNTFVSVSENLNKLKSSIGAIFGIVSLLSRL 143

  Fly   532 -------------DQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVI------------------- 564
                         |:.:.....|.||......:|..|.|..|..::
pombe   144 KRLVLKFFKHSKIDEMNSQEYDVFEKEEGNHKNSIYSIVSSLAIILGLVGLPYAIIRLFKNIYEK 208

  Fly   565 KGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPG 611
            :..:|..|.|.  ::|.|:...|:    |||.|          ||||
pombe   209 EKQIQQAKIRK--KIDSLEFCKAD----YEFMS----------RDPG 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	18/83 (22%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063
pex13	NP_593611.1	Peroxin-13_N	86..202	CDD:282008	16/115 (14%)
pex13	NP_593611.1	SH3_Pex13p_fungal	226..285	CDD:212705	9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030