DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and scd1

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_594221.1	Gene:	scd1 / 2542337	PomBaseID:	SPAC16E8.09	Length:	872	Species:	Schizosaccharomyces pombe

Alignment Length:	943	Identity:	188/943 - (19%)
Similarity:	337/943 - (35%)	Gaps:	228/943 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 EDRTPTNKSVPGTPFHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPA 335
            :||..:::|:|.    :..|..|  .|..||.|.....:.:::..|.:.|..:.:.:    .|.:
pombe     5 QDRKTSSRSLPS----YINHSTQ--NLVGPRKDETNLSEYMKLRLLQSPSQVIYNLE----NTVS 59

  Fly   336 TPTPSATKAKEFVCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDLDPRAE----------LIE 390
            .........|..:....|:.  ..|:|:.:.:....:.|...|....||..|          |..
pombe    60 LYRRCLNLRKRLMDISELAA--FFDSIHREALNSSFKILEFKDIEFDDPVTEIWLFCRLGYPLCA 122

  Fly   391 AVNKTLVNKPLVRSSSAACAST-ICSSPLLTYAR--TKSLGAKASTLGGGVPIKLPTAEQLAELE 452
            ..|...|.:.|..:||.:..:| :|.:.|..:..  ...||.              |...|..:.
pombe   123 LFNCLPVKQKLEVNSSVSLENTNVCKASLYRFMLMCKNELGL--------------TDAALFSIS 173

  Fly   453 EANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYL 517
            |..|.|...|.|          .|..:..|..:...|::..|:|:.|.|..|.:..|.|  .|.:
pombe   174 EIYKPSTAPLVR----------ALQTIELLLKKYEVSNTTKSSSTPSPSTDDNVPTGTL--NSLI 226

  Fly   518 ASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDEL 582
            ||.                      .:...|:.::|..:::|| :.:..|:...:::..|..|.:
pombe   227 ASG----------------------RRVTAELYETELKYIQDL-EYLSNYMVILQQKQILSQDTI 268

  Fly   583 QILFANIEEIYEFNSMLLQRL---INTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKL 644
            ..:|.|:.||.:|....|..|   ::...:..|:...||.|.:||.||..:||::|.|..|:
pombe   269 LSIFTNLNEILDFQRRFLVGLEMNLSLPVEEQRLGALFIALEEGFSVYQVFCTNFPNAQQLI--- 330

  Fly   645 LQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRK-----HCDVKEVVEAHVIM 704
               ....:.|.....||:....|.:.|:||:|||.||.|||:.|.|     :...:|:.:....:
pombe   331 ---IDNQNQLLKVANLLEPSYELPALLIKPIQRICKYPLLLNQLLKGTPSGYQYEEELKQGMACV 392

  Fly   705 RQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHN-------KQRLVL 762
            .:||:.:::.:|..|.::.:.||...:..|.|..|...|:|    |:.:..|       ::..|.
pombe   393 VRVANQVNETRRIHENRNAIIELEQRVIDWKGYSLQYFGQL----LVWDVVNVCKADIEREYHVY 453

  Fly   763 LFATMLIITKQ----KEDGR-------------LQFKTYISQNNLMLSEHLPGEPTSFYVIPF-- 808
            ||..:|:..|:    |...|             ||.|..|..:|  ::..:|......|.|..
pombe   454 LFEKILLCCKEMSTLKRQARSISMNKKTKRLDSLQLKGRILTSN--ITTVVPNHHMGSYAIQIFW 516

  Fly   809 -DEPRHQ---IKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWS 869
             .:|:|:   :||  ||.:..::|...:                             :|..||
pombe   517 RGDPQHESFILKL--RNEESHKLWMSVL-----------------------------NRLLWK-- 548

  Fly   870 LHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFD-----SFNESLEQEEESISQAKP 929
               ..:.:|..:....:...:.:..|:|....|.. |||.:|     |.:|::.......|.:..
pombe   549 ---NEHGSPKDIRSAASTPANPVYNRSSSQTSKGY-NSSDYDLLRTHSLDENVNSPTSISSPSSK 609

  Fly   930 SKPLARNNSLD----DTALQKLAAAMRYRKRDAAVKEETKTPVKEPCKCDQDA-------KQDER 983
            |.|..:..|.|    .|..::.:..:|....::......:|..........|:       .|..|
pombe   610 SSPFTKTTSKDTKSATTTDERPSDFIRLNSEESVGTSSLRTSQTTSTIVSNDSSSTASIPSQISR 674

  Fly   984 IEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEEAEREREQDEDSAASLRGSK 1048
            |...:.:|.|            ::|    .|...:.|:...:           |:.|:.|:....
pombe   675 ISQVNSLLND------------YNY----NRQSHITRVYSGT-----------DDGSSVSIFEDT 712

  Fly  1049 PDLSERK------TKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSCSRFYMDLSEFDSSSSTV 1107
            ...:::|      |........:||::....|...:|......|:.|           .||:||.
pombe   713 SSSTKQKIFDQPTTNDCDVMRPRQYSYSAGMKSDGSLLPSTKHTSLS-----------SSSTSTS 766

  Fly  1108 LKITESTE---ELRPDGEIELAQEAA---TLDE 1134
            |.:..:|.   .||.. |:.|....|   |.||
pombe   767 LSVRNTTNVKIRLRLH-EVSLVLVVAHDITFDE 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	47/172 (27%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	36/174 (21%)
scd1	NP_594221.1	CDC24	105..194	CDD:283938	22/112 (20%)
		RhoGEF	232..401	CDD:279015	47/175 (27%)
		PH_Scd1	404..546	CDD:270066	34/178 (19%)
		PB1	775..848	CDD:214770	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940