DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and Arhgef9

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_006528055.1	Gene:	Arhgef9 / 236915	MGIID:	2442233	Length:	523	Species:	Mus musculus

Alignment Length:	471	Identity:	111/471 - (23%)
Similarity:	201/471 - (42%)	Gaps:	85/471 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 ESLAESENELGDQHHPPAMSVLEKTCL----------------EIVDSERSFVEDLGQVIKGYLQ 569
            :.:.|..:::.:.|..|....|   ||                ||:.:||.:::.|..:.:|||:
Mouse    77 DGVEEGPSDVQNGHLDPNSDCL---CLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLK 138

  Fly   570 DWKERACLRVDE-LQILFANIEEIYEFNSML---LQRLINTGRDP--GRIARCFIDLRDGFDVYT 628
            ..::|..:..|| |:::|.|||:||.|....   |::..|.. ||  ..|..||::.:|||.:|:
Mouse   139 QCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNND-DPHLSEIGPCFLEHQDGFWIYS 202

  Fly   629 TYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLG--SYLLKPVQRILKYHLLLDSLRK- 690
            .||.::.:|...|:||::.:. |.......:|||..:.:.  .:||.|||:|.||.|.|..|.|
Mouse   203 EYCNNHLDACMELSKLMKDSR-YQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKY 266

  Fly   691 ----HCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLG-------PELTVLGE 744
                |.|.:.|..|..:||.|...|::.||:.|...::.:....:..|.|       .||...||
Mouse   267 TAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGE 331

  Fly   745 L----RQEGLLMEQHNKQRLVLLFATMLIITKQKEDGR--LQFKTYISQNNLMLSEHLPGEPTSF 803
            :    :..|     .|:||:..||...:::.|:....|  |.:|..|..:...:.:...|....|
Mouse   332 MAWIYQPYG-----RNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVIDIEDGRDDDF 391

  Fly   804 YVIPFDEPRHQIKL-----------TARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEE 857
            .|    ..::..||           .|:..::|..|.:..:    |:..:....:::.:::...:
Mouse   392 NV----SMKNAFKLHNKETEEVHLFFAKKLEEKIRWLRAFR----EERKMVQEDEKIGFEISENQ 448

  Fly   858 DRTPDRSTWKWSLHSGSNST----PTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLE 918
            .|....:..|.|...|.||.    |:|...::...:.:....:.      :|.|..|: |.|...
Mouse   449 KRQAAMTVRKASKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDG------IAQSQVFE-FTEPKR 506

  Fly   919 QEE---ESISQAKPSK 931
            .:.   ::.|:..|.|
Mouse   507 SQSPFWQNFSRLTPFK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	60/177 (34%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	34/168 (20%)
Arhgef9	XP_006528055.1	SH3_ARHGEF9	14..75	CDD:212908
		RhoGEF	114..293	CDD:214619	60/180 (33%)
		PH_Collybistin_ASEF	298..437	CDD:269931	27/151 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940