DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GEFmeso and ARHGEF9

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001340852.1	Gene:	ARHGEF9 / 23229	HGNCID:	14561	Length:	529	Species:	Homo sapiens

Alignment Length:	417	Identity:	102/417 - (24%)
Similarity:	181/417 - (43%)	Gaps:	75/417 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 ESLAESENELGDQHHPPAMSVLEKTCL----------------EIVDSERSFVEDLGQVIKGYLQ 569
            :.:.|..:::.:.|..|....|   ||                ||:.:||.:::.|..:.:|||:
Human    83 DEVEEGPSDVQNGHLDPNSDCL---CLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLK 144

  Fly   570 DWKERACLRVDE-LQILFANIEEIYEFNSML---LQRLINTGRDP--GRIARCFIDLRDGFDVYT 628
            ..::|..:..|| |:::|.|||:||.|....   |::..|.. ||  ..|..||::.:|||.:|:
Human   145 QCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNND-DPHLSEIGPCFLEHQDGFWIYS 208

  Fly   629 TYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLG--SYLLKPVQRILKYHLLLDSLRK- 690
            .||.::.:|...|:||::.:. |.......:|||..:.:.  .:||.|||:|.||.|.|..|.|
Human   209 EYCNNHLDACMELSKLMKDSR-YQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKY 272

  Fly   691 ----HCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLG-------PELTVLGE 744
                |.|.:.|..|..:||.|...|::.||:.|...::.:....:..|.|       .||...||
Human   273 TAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGE 337

  Fly   745 L----RQEGLLMEQHNKQRLVLLFATMLIITKQKEDGR--LQFKTYISQNNLMLSEHLPGEPTSF 803
            :    :..|     .|:||:..||...:::.|:....|  |.:|..|..:...:.:...|....|
Human   338 MAWIYQPYG-----RNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDF 397

  Fly   804 YVIPFDEPRHQIKL-----------TARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEE 857
            .|    ..::..||           .|:..::|..|.:..:    |:..:....:::.:::...:
Human   398 NV----SMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFR----EERKMVQEDEKIGFEISENQ 454

  Fly   858 DRTPDRSTWKWSLHSGSNST----PTY 880
            .|....:..|.....|.||.    |:|
Human   455 KRQAAMTVRKVPKQKGVNSARSVPPSY 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	60/177 (34%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	34/168 (20%)
ARHGEF9	NP_001340852.1	SH3_ARHGEF9	20..81	CDD:212908
		RhoGEF	120..299	CDD:214619	60/180 (33%)
		PH_Collybistin_ASEF	304..443	CDD:269931	27/151 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940