DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GEFmeso and Arhgef4

DIOPT Version :9

Sequence 1:NP_788403.2 Gene:GEFmeso / 37134 FlyBaseID:FBgn0050115 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001355702.1 Gene:Arhgef4 / 226970 MGIID:2442507 Length:1855 Species:Mus musculus


Alignment Length:1202 Identity:239/1202 - (19%)
Similarity:397/1202 - (33%) Gaps:388/1202 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SDTSERWEDFFGSSTELAPSLLGIYDTLTNSFAAGGVAAAPTATSHESKASSSGDSTPKRSNSNC 71
            |.||.  :|...|...|...|||....|       |.....|..:.|..:|.       |....|
Mouse   684 SRTSS--DDTLSSEETLEGELLGERLDL-------GSECVHTEQNQELPSSD-------RKRGRC 732

  Fly    72 SSSSSTGSSTGSCSSVPTSDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDE--PDGAQLSRLVQ 134
            .:..:..:...:|:.   ..:...|..||||:|.|..|||......:.|..|  |...|::.|..
Mouse   733 GTGDAENAEICACAG---EVEGPLSRVLASSTTTLEFQEPCGGFQQSVLESEQHPACLQMTPLRT 794

  Fly   135 RRSQESQIHGSSSSIASSGSSRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSP 199
            ......::.|.....:.:.:|   .::..:.|:....:.||..|      .|....|..||....
Mouse   795 DMPWSREMPGGDIPYSQALTS---EDLNPVCPSPEERVPHSPCQ------GEPPLHHVHQSVSLE 850

  Fly   200 TQGRYIKTGHSGTPPAAGSAP------KLKLSHIPLSKITGKLS-----------------TQSG 241
            |:...|:.|.||.....|.:|      :||.:.   |||..:|:                 |.:|
Mouse   851 TKSGVIQVGTSGDLSGEGPSPESYNIKRLKTTE---SKIKARLALAHKTFTNFFEAKVMEKTNTG 912

  Fly   242 SELVSTFDSSNEYLNSV--AFAAFEKSKPQDEDRTPTNKS---VPGTP----------------- 284
            |     .....|.....  ::.||.:||..:..:.|...|   .||.|                 
Mouse   913 S-----VKGEKEKRRRARGSWRAFLRSKDAEGSKRPALVSGVPEPGFPQLLCSSPPATRGHCEKW 972

  Fly   285 -FHFDGHPF-------------QGRKLTLP--RYDSQQSIKLIEMEQ----------------LA 317
             ...|.|.|             ....|..|  |..|:.:|:....::                .:
Mouse   973 TIDTDSHVFGEHWTPLNSPATLSSSHLASPEHRRRSEPTIRRTAAQESSTHLSSGVFPKSSWLTS 1037

  Fly   318 ATS---AQL-----------LHAKPATPGTPATPT------PSATKAKEFVC----SEPLSPVDI 358
            |||   ||:           .|......|.|..||      |.|...:..:|    :..:|.|.:
Mouse  1038 ATSPGAAQIDISFALPCSSACHLTYENQGMPCRPTSPKPRSPMAGAQRMDLCLRGRTSAVSMVSL 1102

  Fly   359 VDTINFDLVAQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAAC---ASTI------- 413
            ....:.:..::..||     |.....||.|:.::.....|......|...|   ..|:       
Mouse  1103 RSDKDANRSSEVPER-----PKASKARASLLLSLQTLNQNDQKEDKSQCQCYHGLGTVPFLRDHP 1162

  Fly   414 -----------------CSSPLLTYAR-----------TKSL-GAKASTLGGGVPIKLPTAEQLA 449
                             ||....||..           |::| ...|..:...||::...|.|.:
Mouse  1163 GNESYIAQESPPDKKRNCSHDQKTYTEPPHRPVSATEVTRTLPSMSAEQVPREVPLQFRRAPQHS 1227

  Fly   450 E-------LEEANK------------LSAESLD-------RLTDIK-------PKFAARLSELAR 481
            .       ||:|.:            :.||.:.       |.|.|.       |:.:..||:.|.
Mouse  1228 HFSFDDIWLEKAQRRKLKKQMLLRRQMCAELVPEDPVQCWRKTTITSPESPHLPRRSHLLSQSAP 1292

  Fly   482 LN------NRPLSSS--------SICSTSSSSS------------------SGSDQLLNGKLMAT 514
            :.      ..|.|.:        ::|:..:.|.                  .|.:||...:|::.
Mouse  1293 MGLDHTGWPEPTSDTGMPDGTLDTVCAEETGSEEDLYEELHNSGHHYSHPRGGGEQLAINELISD 1357

  Fly   515 SYLASVESLAE----SENELG-------------------------------------------- 531
            ..:...|:|.:    .:.|||                                            
Mouse  1358 GSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPA 1422

  Fly   532 DQHHPPAMSVLE--------KTCL---------EIVDSERSFVEDLGQVIKGYLQDWKERACLRV 579
            |.:..|.....|        ::|.         ||:.:||.:::.|..:.:||::..::|..:..
Mouse  1423 DDYEAPRAGAREADDSGPEAQSCKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKREDMFS 1487

  Fly   580 DE-LQILFANIEEIYEFNSML---LQRLINTGRDP-GRIARCFIDLRDGFDVYTTYCTSYPEA-- 637
            :| |:.:|.|||:||......   |::..||.|.. ..:..||::.:..|.:|:.||.::|.|  
Mouse  1488 EEQLRTIFGNIEDIYRCQKAFVKALEQKFNTERPHLSELGACFLEHQADFQIYSEYCNNHPNACV 1552

  Fly   638 -ISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRK-----HCDVKE 696
             :|.||||.:..:.:......|:::.  :.|..:||.|||:|.||.|.|..|.|     |.|.|.
Mouse  1553 ELSRLTKLSKYVYFFEACRLLQRMID--ISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKN 1615

  Fly   697 VVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTV-LGELRQEGLLM-----EQH 755
            |..|...|:.||..|::.||:.|...::.:....::.|.|.:|.| ..||...|.|.     :..
Mouse  1616 VEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIHSGELTRVTQPQAR 1680

  Fly   756 NKQRLVLLFATMLIITKQKEDGR--LQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIK-- 816
            ::||:..||...||..|:....|  |.:|..:..::|.:.:...|:....:|        .:|  
Mouse  1681 SQQRMFFLFDRQLIYCKKDLLRRDVLYYKGRLDMDDLEVVDVEDGKDRDLHV--------SVKNA 1737

  Fly   817 -------------LTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKW 868
                         |.||..:||:.|   :|....|:..:.:                 |:.|   
Mouse  1738 FRLYCGTTGDSHLLCARKPEQKQRW---LKAFAREREQVRL-----------------DQET--- 1779

  Fly   869 SLHSGSNSTPTYLERRNACRRSEIRQRNSKFK 900
                  ..:.|.|:|:.|...:..:|...|.|
Mouse  1780 ------GFSITELQRKQAMLNASKQQATGKPK 1805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GEFmesoNP_788403.2 RhoGEF 548..713 CDD:279015 56/177 (32%)
PH_PLEKHG1_G2_G3 694..839 CDD:270063 39/167 (23%)
Arhgef4NP_001355702.1 SH3_ASEF 1344..1416 CDD:212906 9/71 (13%)
RhoGEF 1450..1631 CDD:238091 55/182 (30%)
PH_Collybistin_ASEF 1637..1776 CDD:269931 31/166 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.