DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and Vav2

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_006497917.1	Gene:	Vav2 / 22325	MGIID:	102718	Length:	878	Species:	Mus musculus

Alignment Length:	797	Identity:	162/797 - (20%)
Similarity:	294/797 - (36%)	Gaps:	209/797 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 LTDIKPKFAARLSELARLNNRPLS-SSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESEN 528
            |.|:: .|...:|.::||:...:: |..|....|..::.:|.         ....|:|.||: |:
Mouse    99 LFDVR-DFGKVISAVSRLSLHSIAQSKGIRPFPSEETAENDD---------DVYRSLEELAD-EH 152

  Fly   529 ELGD----------------------QHHPPAMSVLEK---------TC--LEIVDSERSFVEDL 560
            :||:                      :...|.:..::|         :|  |||.::|..:...|
Mouse   153 DLGEDIYDCVPCEDEGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRSCCLLEIQETEAKYYRTL 217

  Fly   561 GQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPG--RIARCFIDLRDG 623
            ..:.|.|:...  |..|...::..:|.|:|::.:.:...| |.|:.....|  .:|:.|::.::.
Mouse   218 EDIEKNYMGPL--RLVLSPADMAAVFINLEDLIKVHHSFL-RAIDVSMMAGGSTLAKVFLEFKER 279

  Fly   624 FDVYTTYCTSYPEAISLLTKLLQATHTY--SLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLD 686
            ..:|..||:....|.|.|.:||.:...:  .:...|.::...:..|...|:.|:||:|||||||.
Mouse   280 LLIYGEYCSHMEHAQSTLNQLLASREDFRQKVEECTLRVQDGKFKLQDLLVVPMQRVLKYHLLLK 344

  Fly   687 SLRKHC-------DVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKE-------LSGILDGWLGP 737
            .|..|.       .:||.:||   |:.:|..|::|||.:|...::.|       |...|:.:..|
Mouse   345 ELLSHSADRPERQQLKEALEA---MQDLAMYINEVKRDKETLKKISEFQCSIENLQVKLEEFGRP 406

  Fly   738 ELTVLGELRQEGLLMEQHNKQ-RLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPT 801
            ::.  |||:...::  .|.|| |.:.||..::|:.|:| ....:.|..|.    :|...:..:|.
Mouse   407 KID--GELKVRSIV--NHTKQDRYLFLFDKVVIVCKRK-GYSYELKEVIE----LLFHKMTDDPM 462

  Fly   802 ---------------SFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVY 851
                           .||:|.. :.:...:...:..|.||.|        :|:.::.|
Mouse   463 HNKDIKKSHGKMWSYGFYLIHL-QGKQGFQFFCKTEDMKRKW--------MEQFEMAM------- 511

  Fly   852 QLGNEEDRTPDRSTWKWSLHSGSNSTPTY-LERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNE 915
                 .:..||::      ::..:|...| .::...|:..::..|.: |.:..:.......:..|
Mouse   512 -----SNIKPDKA------NANHHSFQMYTFDKTTNCKACKMFLRGT-FYQGYLCTRCGVGAHKE 564

  Fly   916 SLEQEEESISQAKPSKPLARNNSLDDTAL---QKLAAAMRYRKRDAAVKEETKT----PVKEPCK 973
            .|    |.|...|.|.|.    .:|....   .|:.|...|....|...:...|    .|.|..:
Mouse   565 CL----EVIPPCKMSSPA----DVDAPGAGPGPKMVAVQNYHGNPAPPGKPVLTFQTGDVIELLR 621

  Fly   974 CDQDAK---------------QDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGG 1023
            .|.|:.               ....::||..   |.|..:.:..|....|.|       .|...|
Mouse   622 GDPDSPWWEGRLVQTRKSGYFPSSSVKPCPV---DGRPPTGRPPSREIDYTA-------YPWFAG 676

  Fly  1024 FSLDEEAEREREQDEDSAASLRGSKPDLSERKTKGKGFF-------EVK--------QYNHKTMP 1073
                   ..||:|.::...|.......:.||..:.:.|.       |||        .:.|.|..
Mouse   677 -------NMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWIHITEA 734

  Fly  1074 KKIANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVLKITESTEELRPDGEIEL---AQEAATLDES 1135
            ||..:|               ::|.|:....|    :.||.::|  |..::.   ::|..|...|
Mouse   735 KKFESL---------------LELVEYYQCHS----LKESFKQL--DTTLKFPYKSRERTTSRAS 778

  Fly  1136 TQDQYYSPDHETELLSP 1152
            ::.......:....|||
Mouse   779 SRSPASCASYNFSFLSP 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	47/175 (27%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	38/167 (23%)
Vav2	XP_006497917.1	CAMSAP_CH	18..103	CDD:314792	2/3 (67%)
		RhoGEF	202..375	CDD:214619	48/178 (27%)
		PH_Vav	389..516	CDD:269930	28/156 (18%)
		C1	524..571	CDD:237996	9/51 (18%)
		SH3_VAV2_1	590..649	CDD:212913	9/58 (16%)
		SH2_Vav2	667..769	CDD:198269	26/136 (19%)
		SH3_VAV2_2	819..876	CDD:212910
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940