DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and Vav1

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_035821.3	Gene:	Vav1 / 22324	MGIID:	98923	Length:	845	Species:	Mus musculus

Alignment Length:	894	Identity:	175/894 - (19%)
Similarity:	302/894 - (33%)	Gaps:	286/894 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 LIEAVNKTLVN-KPLVRSSSAACASTICSSPLLTYART--KSLGAKASTLGGGVPIKLPTAEQLA 449
            |.:|:|...|| :|.:       :..:|...:.|:..|  :..|.|.|.|
Mouse    51 LPQAINLREVNLRPQM-------SQFLCLKNIRTFLSTCCEKFGLKRSEL--------------- 93

  Fly   450 ELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMAT 514
                     .|:.| |.|:: .|...:..|:.|:..|::.:.    ........|..||.:.:.:
Mouse    94 ---------FEAFD-LFDVQ-DFGKVIYTLSALSWTPIAQNK----GIMPFPTEDSALNDEDIYS 143

  Fly   515 SYLASVESLAESENEL----------GDQHH-----------PPAMSVLEKTCL---EIVDSERS 555
            .....::..||.:.:|          ||:.:           ||.|:..:|.|.   ||..:|..
Mouse   144 GLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRLESVPTPPKMTEYDKRCCCLREIQQTEEK 208

  Fly   556 FVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPG--RIARCFI 618
            :.:.||.:.:.:::..:.  .|:..:::.:|.||||::..::..|:.|.:....||  .:.:.||
Mouse   209 YTDTLGSIQQHFMKPLQR--FLKPQDMETIFVNIEELFSVHTHFLKELKDALAGPGATTLYQVFI 271

  Fly   619 DLRDGFDVYTTYCTSYPEAISLLTKLLQATH--TYSLLASTQKLLQHRLPLGSYLLKPVQRILKY 681
            ..::.|.||..||:....|...|.::..|..  ...|...:|:....|..|...|:.|:||:|||
Mouse   272 KYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKY 336

  Fly   682 HLLLDSLRKHC-DVKEVVEAHV---IMRQVAHNIDQVKRKQEQ-------QSRVKELSGILDGWL 735
            ||||..|.||. |..|.....:   .||.:|..:::|||..|.       |..::.|...|..:.
Mouse   337 HLLLQELVKHTQDATEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYG 401

  Fly   736 GPELTVLGELRQEGLLMEQHNK-QRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGE 799
            .|::.  |||:...  :|:.:| .|...|....|:|.|::.|. ...|..::.::..:.:...||
Mouse   402 RPKID--GELKITS--VERRSKTDRYAFLLDKALLICKRRGDS-YDLKASVNLHSFQVRDDSSGE 461

  Fly   800 P-----TSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDR 859
            .     :..:::..|:.....:|..:.|:.|:.|        :|:.::.:
Mouse   462 RDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKW--------MEQFEMAI--------------- 503

  Fly   860 TPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEESI 924
                          ||..|     .||                 .||...|..|:      .|..
Mouse   504 --------------SNIYP-----ENA-----------------TANGHDFQMFS------FEET 526

  Fly   925 SQAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVKEPCKCDQDAKQDERIEPC-- 987
            :..|..:.|.|.     |..|....   ||.|..|.||         |.        .|:.||
Mouse   527 TSCKACQMLLRG-----TFYQGYRC---YRCRAPAHKE---------CL--------GRVPPCGR 566

  Fly   988 ------SCILRDQRSRSAKSQSPVFSYKALKERSKSVPRI-------------GGFS-------- 1025
                  ..:.:|:..|.|:.:         |.....:|::             |.|.
Mouse   567 HGQDFAGTMKKDKLHRRAQDK---------KRNELGLPKMEVFQEYYGIPPPPGAFGPFLRLNPG 622

  Fly  1026 -----LDEEAEREREQDEDSAAS-------------LRGSKPDLS---------ER-------KT 1056
                 ...|||....:..::|.:             :.|...|||         ||       ..
Mouse   623 DIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVHPYVHGPPQDLSVHLWYAGPMERAGAEGILTN 687

  Fly  1057 KGKGFFEVKQ-------------YNHKTMPKKIANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVL 1108
            :..|.:.|:|             ||.:....||...:.....|.|...|..::|.||...:|
Mouse   688 RSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLLELVEFYQQNS--- 749

  Fly  1109 KITESTEELRPDGEIELAQEAATLDESTQDQYYSPDHETELLSPAEKSK 1157
                            |.....:||.:.|..|..|:.......||..:|
Mouse   750 ----------------LKDCFKSLDTTLQFPYKEPERRAISKPPAGSTK 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	48/172 (28%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	31/160 (19%)
Vav1	NP_035821.3	CH	18..102	CDD:320720	16/82 (20%)
		RhoGEF	195..371	CDD:238091	49/177 (28%)
		PH_Vav	385..508	CDD:269930	26/164 (16%)
		C1_1	516..567	CDD:278556	18/81 (22%)
		SH3_VAV1_1	596..658	CDD:212912	6/61 (10%)
		SH2_Vav1	665..767	CDD:198268	24/120 (20%)
		SH3_VAV1_2	786..839	CDD:212909
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940