Protein Alignment GEFmeso and Vav1

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_035821.3
• Gene: Vav1 / 22324
• MGIID: 98923
• Length: 845
• Species: Mus musculus
• Alignment Length: 894
• Identity: 175/894 - (19%)
• Similarity: 302/894 - (33%)
• Gaps: 286/894 - (31%)

  Fly   388 LIEAVNKTLVN-KPLVRSSSAACASTICSSPLLTYART--KSLGAKASTLGGGVPIKLPTAEQLA 449
            |.:|:|...|| :|.:       :..:|...:.|:..|  :..|.|.|.|
Mouse    51 LPQAINLREVNLRPQM-------SQFLCLKNIRTFLSTCCEKFGLKRSEL--------------- 93

  Fly   450 ELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMAT 514
                     .|:.| |.|:: .|...:..|:.|:..|::.:.    ........|..||.:.:.:
Mouse    94 ---------FEAFD-LFDVQ-DFGKVIYTLSALSWTPIAQNK----GIMPFPTEDSALNDEDIYS 143

  Fly   515 SYLASVESLAESENEL----------GDQHH-----------PPAMSVLEKTCL---EIVDSERS 555
            .....::..||.:.:|          ||:.:           ||.|:..:|.|.   ||..:|..
Mouse   144 GLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRLESVPTPPKMTEYDKRCCCLREIQQTEEK 208

  Fly   556 FVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPG--RIARCFI 618
            :.:.||.:.:.:::..:.  .|:..:::.:|.||||::..::..|:.|.:....||  .:.:.||
Mouse   209 YTDTLGSIQQHFMKPLQR--FLKPQDMETIFVNIEELFSVHTHFLKELKDALAGPGATTLYQVFI 271

  Fly   619 DLRDGFDVYTTYCTSYPEAISLLTKLLQATH--TYSLLASTQKLLQHRLPLGSYLLKPVQRILKY 681
            ..::.|.||..||:....|...|.::..|..  ...|...:|:....|..|...|:.|:||:|||
Mouse   272 KYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKY 336

  Fly   682 HLLLDSLRKHC-DVKEVVEAHV---IMRQVAHNIDQVKRKQEQ-------QSRVKELSGILDGWL 735
            ||||..|.||. |..|.....:   .||.:|..:::|||..|.       |..::.|...|..:.
Mouse   337 HLLLQELVKHTQDATEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYG 401

  Fly   736 GPELTVLGELRQEGLLMEQHNK-QRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGE 799
            .|::.  |||:...  :|:.:| .|...|....|:|.|::.|. ...|..::.::..:.:...||
Mouse   402 RPKID--GELKITS--VERRSKTDRYAFLLDKALLICKRRGDS-YDLKASVNLHSFQVRDDSSGE 461

  Fly   800 P-----TSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDR 859
            .     :..:::..|:.....:|..:.|:.|:.|        :|:.::.:
Mouse   462 RDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKW--------MEQFEMAI--------------- 503

  Fly   860 TPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQEEESI 924
                          ||..|     .||                 .||...|..|:      .|..
Mouse   504 --------------SNIYP-----ENA-----------------TANGHDFQMFS------FEET 526

  Fly   925 SQAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVKEPCKCDQDAKQDERIEPC-- 987
            :..|..:.|.|.     |..|....   ||.|..|.||         |.        .|:.||
Mouse   527 TSCKACQMLLRG-----TFYQGYRC---YRCRAPAHKE---------CL--------GRVPPCGR 566

  Fly   988 ------SCILRDQRSRSAKSQSPVFSYKALKERSKSVPRI-------------GGFS-------- 1025
                  ..:.:|:..|.|:.:         |.....:|::             |.|.
Mouse   567 HGQDFAGTMKKDKLHRRAQDK---------KRNELGLPKMEVFQEYYGIPPPPGAFGPFLRLNPG 622

  Fly  1026 -----LDEEAEREREQDEDSAAS-------------LRGSKPDLS---------ER-------KT 1056
                 ...|||....:..::|.:             :.|...|||         ||       ..
Mouse   623 DIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVHPYVHGPPQDLSVHLWYAGPMERAGAEGILTN 687

  Fly  1057 KGKGFFEVKQ-------------YNHKTMPKKIANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVL 1108
            :..|.:.|:|             ||.:....||...:.....|.|...|..::|.||...:|
Mouse   688 RSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLLELVEFYQQNS--- 749

  Fly  1109 KITESTEELRPDGEIELAQEAATLDESTQDQYYSPDHETELLSPAEKSK 1157
                            |.....:||.:.|..|..|:.......||..:|
Mouse   750 ----------------LKDCFKSLDTTLQFPYKEPERRAISKPPAGSTK 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	48/171 (28%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	31/160 (19%)
Vav1	NP_035821.3	CH_VAV1	2..121	CDD:409111	21/102 (21%)
		RhoGEF	195..371	CDD:238091	49/177 (28%)
		PH_Vav	385..508	CDD:269930	26/164 (16%)
		C1_VAV1	510..566	CDD:410417	22/103 (21%)
		SH3_VAV1_1	596..658	CDD:212912	6/61 (10%)
		SH2_Vav1	665..767	CDD:198268	24/120 (20%)
		SH3_VAV1_2	786..839	CDD:212909