Protein Alignment GEFmeso and SPATA13

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_001273721.1
• Gene: SPATA13 / 221178
• HGNCID: 23222
• Length: 1339
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 239/1076 - (22%)
• Similarity: 362/1076 - (33%)
• Gaps: 329/1076 - (30%)

  Fly     6 DSDTSERWEDFFGSSTELAPSLLGIY------------DTLTNSFAAGGVAAA-------PTATS 51
            |....|..:|.|..||..:.||...|            :..|.:.|.|.|.|.       |...|
Human   244 DGSDLEDTDDAFQRSTHRSRSLRRAYGLGRICLLDAPQNHATPTIATGQVPAVCEILVRDPENNS 308

  Fly    52 HESKASSSGD--------STPKRSNSNCS---------------SSSSTGSS------TGSCSSV 87
            ...:.|.|.|        |..::|.||.:               |||||.|.      |....|.
Human   309 MGYRRSKSTDNLAFLKKSSFKRKSTSNLADLRTAHDARVPQRTLSSSSTDSQKLGSGRTKRWRSP 373

  Fly    88 PTSDDQSASYTLASSSTHLG-HQEPP---APLVVAGLRDEPDGAQL------------SRLVQRR 136
            ..:.|....:.|.|:.|... .:|.|   ||        .|..|.|            ||.|.|.
Human   374 IRAKDFDRVFKLVSNVTEAAWRRESPRSGAP--------SPGEASLRLQAHSRLHDDYSRRVSRS 430

  Fly   137 SQESQ------IHGS--------------------------------SSSIASSGSSRRGSNI-- 161
            :::..      :||:                                ||....|.||...|::
Human   431 TEQDSRRGGAVMHGTTATCTVAPGFGSATSKGPHLDADTAVFPLETKSSWAVESDSSCTCSSLPS 495

  Fly   162 ----RILS-----PNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQG-RYIKTGHSGTPPAA 216
                .:||     ||....:|....||...:.....|....||.:||..| ....:.||..  :|
Human   496 PIVQDVLSKDSCDPNAGSQLTFDPEQPPTPLRPTTPKPQSPQSPQSPGAGSASCHSNHSAL--SA 558

  Fly   217 GSAPKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAA---------------FEKS 266
            .|......:..|..:..|.:|.|...|.....:.|.:.|.::..||               :.:|
Human   559 NSEESEGRAEEPAQREPGPVSLQDPLEATHGDEGSKDLLVNIGVAAGPEEKEKEEVVPDGPWRRS 623

  Fly   267 KPQDEDRTPTNKSVPGTPFHFDG-------HPFQ------GRKLTLPR----YDSQQSIKLIEME 314
            ..|||:||...:    ||....|       .||.      .|.|::|.    .|.|:..::.|..
Human   624 SSQDEERTEAQR----TPKRRWGSGRRPRPRPFSDYGQLASRSLSIPEDSVAADPQKEDRVDEDP 684

  Fly   315 QLAATSA---------------------------------------QLLHAKPATPGTPATPTP- 339
            |.:.|||                                       .||....:.|..||...|
Human   685 QASMTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQVPP 749

  Fly   340 -SATKAK----EFVCSEPL----------------------SPVDIVDTINFDLVAQHMERLTLA 377
             .|..|:    .|..|.|:                      .|..:||. |........|.|..|
Human   750 YKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDD-NGSEEDFSYEDLCQA 813

  Fly   378 DPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKL 442
            .|..|.|..|.: |:|:      |:...:..||..:.....:.   .:.||.||
Human   814 SPRYLQPGGEQL-AINE------LISDGNVVCAEALWDHVTMD---DQELGFKA----------- 857

  Fly   443 PTAEQLAELEEANKLSAESLD----RLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGS 503
              .:.:..||.:||      |    |..|.:..|.|....| |:|...||.:|    ||:.|...
Human   858 --GDVIQVLEASNK------DWWWGRSEDKEAWFPASFVRL-RVNQEELSENS----SSTPSEEQ 909

  Fly   504 DQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYL 568
            |                |..::|.:    :|......:......||:|:||.:::.|..:.:||:
Human   910 D----------------EEASQSRH----RHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYI 954

  Fly   569 -QDWKERACLRVDELQILFANIEEIYEFNSMLLQRLIN--TGRDP--GRIARCFIDLRDGFDVYT 628
             |..|......|.:|..:|.|||:||:|....|:.|..  ...:|  ..|..||:..::||.:|:
Human   955 RQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYS 1019

  Fly   629 TYCTSYPEAISLLTKLLQA---THTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRK 690
            .||.::|.|...|..|::.   .|.:......|:::.  :.:..:||.|||:|.||.|.|..|.|
Human  1020 EYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMID--IAIDGFLLTPVQKICKYPLQLAELLK 1082

  Fly   691 -----HCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLG-------PELTVLG 743
                 |.|...:..|:..|:.||..|::.|||.|...::......:.||.|       .||...|
Human  1083 YTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSG 1147

  Fly   744 ELRQEGLLMEQHNKQRLVLLFATMLIITKQ---KEDGRLQFKTYISQNNLMLSEHLPGEPTSFYV 805
            ||.:  :..:..::||...||...|:..|:   :.| .|.:|..:..:.:.|.:...|......:
Human  1148 ELTK--ITKQGKSQQRTFFLFDHQLVSCKKDLLRRD-MLYYKGRLDMDEMELVDLGDGRDKDCNL 1209

  Fly   806 IPFDEPRHQIKLTARNRDQ-----------KRIWTQ 830
                ..::..||.:|..|:           |..|.|
Human  1210 ----SVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQ 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	54/176 (31%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	35/158 (22%)
SPATA13	NP_001273721.1	SH3_ASEF	821..892	CDD:212906	20/100 (20%)
		RhoGEF	931..1110	CDD:214619	55/180 (31%)
		PH_Collybistin_ASEF	1115..1253	CDD:269931	27/134 (20%)