Protein Alignment GEFmeso and Plekhg1

DIOPT Version :9

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_006512502.1
• Gene: Plekhg1 / 213783
• MGIID: 2676551
• Length: 1487
• Species: Mus musculus
• Alignment Length: 1521
• Identity: 334/1521 - (21%)
• Similarity: 565/1521 - (37%)
• Gaps: 480/1521 - (31%)

  Fly   375 TLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACAST-------------ICSSPLLTYARTKS 426
            |.|:|.: .|..:.:|..:.   ::|:...|:::.||:             :.:|.|..:.:.|.
Mouse    85 TTAEPSE-SPEPKTMELSDS---DRPISFGSTSSSASSRDSHGSFGSRMTLVSNSHLGLFHQDKE 145

  Fly   427 LGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSS 491
            .||          |||       ||..|...|:..|.|.....|:....:||........:.:|.
Mouse   146 AGA----------IKL-------ELVPARPFSSSELQRDKPAGPQNMNGVSEKQPRTPWRMDTSG 193

  Fly   492 ICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSF 556
            ...|::.|             |||                     |.:..:::...||:::||::
Mouse   194 TPQTTADS-------------ATS---------------------PKLLYVDRVVQEILETERTY 224

  Fly   557 VEDLGQVIKGYLQDWKERACLR--------VDELQILFANIEEIYEFNSMLLQRLINTGRDPGRI 613
            |:||..:::|||:      |:|        .::...||.||::||.|||.|||.|.|...||..|
Mouse   225 VQDLKSIVEGYLE------CIRDQTKLPLVTEDRAALFGNIQDIYHFNSELLQDLENCENDPVAI 283

  Fly   614 ARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRI 678
            |.||:...:.|.:||.|||:||.::::||:.::...........|:.|:|.||||||||||||||
Mouse   284 AECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILTKFFRERQETLRHSLPLGSYLLKPVQRI 348

  Fly   679 LKYHLLLDSLRKHCD-----VKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPE 738
            |||||||..:..|.|     ...|::|...|::||.:|:.:|||.|...|::|:..:|..|.||:
Mouse   349 LKYHLLLHEIENHLDKATEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWEGPD 413

  Fly   739 LTVLGELRQEGLL-MEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTS 802
            ||..|||..||.. :::..|:|.:.|...:|:|||:::| ...:|.:|...||||.|.:|.||.|
Mouse   414 LTSYGELVLEGTFRIQKAKKERTLFLLDQLLLITKKRDD-TFTYKAHILCGNLMLVEVIPKEPLS 477

  Fly   803 FYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEK----LDIPMRAKELVYQLGNEEDRTPDR 863
            |.|..:..|:.|..:.|:::..||:|..|:|.::||.    ..||.:||:.:.::.
Mouse   478 FSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAAAKIPAKAKQAILEMD--------- 533

  Fly   864 STWKWSLH--------SGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLEQE 920
                 ::|        .|...||.........|:||...|:.|. .||...|......:     .
Mouse   534 -----AIHYPGFCYSPEGEMKTPCGSAPHRLRRKSEPSSRSHKV-LKTSETSQDIQKVS-----R 587

  Fly   921 EESISQAKPSKPLARNNSLDDTALQKL---AAAMRYRKRDAAVKEETKTPVKEPC---------- 972
            |||.||...:.|..||......|:..:   ...:|....|..:::.|...:::|.
Mouse   588 EESPSQLTSAVPAQRNCQPGSAAVINMLRGGGGVRSPWTDHHIRQRTDHHIRQPLFPSRRSPQEN 652

  Fly   973 -----------------------KCDQDAKQDERIEPCSCIL-------------RDQRSRSAKS 1001
                                   .|:::|..    .|||..|             |..|..|:..
Mouse   653 EDDDDDYQMFVPSFSSSDLNSTRLCEENASS----RPCSWHLGLIEPTEISSSGHRIVRRASSAG 713

  Fly  1002 QS----PVFSYKALKE-------RSKSVPRIGG------------------------FSLDEEAE 1031
            :|    |....:...:       :.::.||.||                        .|.::...
Mouse   714 ESNACPPEVRIRDCDDSQYCPGRQLQNSPRPGGERGMTPYGSSVELTIDDIDHVYDNISFEDLKL 778

  Fly  1032 REREQDEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTM---PKKIANLKKQRSSTTKSCSRF 1093
            ...::||...:..:.|:..:..:.|....|.: :|.:|.|.   .:|.|.|..|.:||.......
Mouse   779 MVAKRDETECSFSKPSRDSVRPKSTPELAFSK-RQVSHSTSSLHSRKEAGLGGQEASTQSVHEHQ 842

  Fly  1094 YMDLSEFDS-----------SSSTVLKITEST-----------EELRPDGEIELAQEAATLDEST 1136
            .::.:.:|:           :.|::.:...||           :.|||    .::|::....|..
Mouse   843 EVEENIYDTIGLPDPPSMNLNHSSLHQPKRSTFLGLEADFACCDSLRP----FVSQDSLQFSEDD 903

  Fly  1137 QDQYYSPDHETELLSPAEKSKRDAQIVLDLL---KNSKEFERIYN--------KQQKRRESPVS- 1189
            ...:..|. :||.||....|.|....:.|..   |.|:|.:.|:|        .:.|.|:..::
Mouse   904 ISYHQGPS-DTEYLSLLYDSPRCNLPIADKALSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAA 967

  Fly  1190 -PVSPD----------------------------ISRGPILP----------------------- 1202
             |||.|                            .|:..:||
Mouse   968 FPVSKDDAPERLYVDSTHELGRDTGHATSMLALPTSQTFLLPGKSRVVRASRANCSLDNDIISTE 1032

  Fly  1203 ------------PPRPPSRSPPPL------ELEEQEKKPVEEVDSVSEEPI------YETLLRNV 1243
                        ...||..:|..|      :.:.:...|..||...::..:      |...::.|
Mouse  1033 GSFLSLNQLSLASDGPPVDNPYDLANCSLPQTDPENPDPGMEVTDKTKSRVFMMARQYSQKIKKV 1097

  Fly  1244 HVPYKF-SPVLGRAKSSQ----------ILKKRSKTAPAASRPESDYVTLVYSPEGVLQRVGEEV 1297
            :...|. ||.|.:..|||          ||:::.:..||.....::|..|.           :::
Mouse  1098 NQILKVKSPELEQPPSSQHRPSHKDLVAILEEKRQGGPAIGARIAEYSQLY-----------DQI 1151

  Fly  1298 VQRDSCSSSTTSTSSNGSGSTLKRD-------------------SQSTVINLLMEAAQEHESR-P 1342
            |.|::...:.....::..|.||.|.                   |...:.:...:..|:.:|: |
Mouse  1152 VFRETPLKAQKDGWASPQGPTLHRPVSPPQAQGAGEDWLWHSPYSNGELADFSPQTEQDSKSKYP 1216

  Fly  1343 LPKNSVSGSESSLLPRALKSIDNLSMAFGRSNRPPERRVSD-----VSEMCR------------Q 1390
            :...|.    :.:.||.|....::          |..:|||     |.:.|.            |
Mouse  1217 ITLEST----TKIRPRQLSGACSV----------PSLQVSDPLLGSVQQRCSVVVSQPHKENSGQ 1267

  Fly  1391 SVLHRQ-GSEAVGERMAHVDYADPKALF------GLGVLNH-SERDSVFSLTSSSSD-------- 1439
            |.|:.. |.:|:..:..  .|:.|::..      .|..:|: ||.::...|:|..|.
Mouse  1268 SPLYNSLGRKAISAKPQ--PYSRPQSSSSILINKSLDSINYPSETETKQLLSSQKSPRGASQQDL 1330

  Fly  1440 -----SMCEQQR-KRSGVGATFEYEQQV-----------EDSLEN---DFRDSAIYSDDN-EKRS 1483
                 :.|:|.| |||.:  |.:..|:|           :.:.:|   :|:|.....||. |.:|
Mouse  1331 PSGLANSCQQDRGKRSDL--TLQDSQKVLVVNRNLPLSAQIATQNYFCNFKDPEGDEDDYVEIKS 1393

  Fly  1484 GDYDVHL------RRPSSPPPPPP-----------------PLGPRPHQPPQI------------ 1513
            .:.:|.|      .|.|.|..|.|                 |:..|...||.:
Mouse  1394 EEDEVRLDLSPRRGRKSDPQTPDPDCSDSICSHSTPYSLKEPVSGRLGLPPYLTACKDSDKLNDY 1458

  Fly  1514 ---APKPSKDQLIQQRSGVIVCQSAS 1536
               .|.|::..::|.......|.|:|
Mouse  1459 LWRGPSPNQQNIVQSLREKFQCLSSS 1484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	74/177 (42%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	53/145 (37%)
Plekhg1	XP_006512502.1	RhoGEF	211..387	CDD:238091	73/181 (40%)
		PH_PLEKHG1_G2_G3	369..514	CDD:270063	53/145 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4732
eggNOG	1	0.900	-	-		E1_KOG3518
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	214	1.000	Inparanoid score	I3617
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004049
OrthoInspector	1	1.000	-	-		otm43616
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45924
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X3795
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.950