DRSC/TRiP Functional Genomics Resources

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Protein Alignment GEFmeso and vav-1

DIOPT Version :9

Sequence 1:NP_788403.2 Gene:GEFmeso / 37134 FlyBaseID:FBgn0050115 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001359918.1 Gene:vav-1 / 181153 WormBaseID:WBGene00006887 Length:1007 Species:Caenorhabditis elegans


Alignment Length:961 Identity:204/961 - (21%)
Similarity:338/961 - (35%) Gaps:294/961 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   451 LEEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSS-------SICSTSSSSSSGS----- 503
            ||:|:..:||.|..:..    |...|..|:.|::...|.|       ...:....:|:||     
 Worm   119 LEDADLFTAEDLYYMNG----FQKVLKTLSFLSHTKESLSRGVDPFPDTDNNQEGTSNGSEFEDD 179

  Fly   504 --------DQLLNGKLMATSY--LASVESLAESENELGDQ---HHPPAMSV--LEKT-------C 546
                    |.:.|.....|.|  :.|.:...:...:|.|:   :..|:|:.  |:.|       |
 Worm   180 VEIYQSLHDNIENVDPNRTIYGPITSADPEEQQSEQLYDRIVTNRKPSMNENDLQNTPTLKRNRC 244

  Fly   547 L-EIVDSERSFV-EDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRL-----I 604
            : |:.|:|:::| :.|..:||.:.:..|  ..:...:..|:|.|||||...::.||..|     :
 Worm   245 IRELYDTEKNYVAQALVTIIKTFYEPLK--GIIPTSDYNIIFGNIEEINVLHTALLADLEYPVKV 307

  Fly   605 NTGRD--------------PGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLA 655
            ..|..              |..|...||..||.|..|..||::.|::..|..:||:.....|  .
 Worm   308 ALGLSDATPPRPISLNECVPQTIGEVFIKYRDQFLAYGKYCSNLPDSRKLSNELLKTNEFIS--R 370

  Fly   656 STQKLLQH---RLPLGSYLLKPVQRILKYHLLLDSLRKHCDV-----KEVVEAHVIMRQVAHNID 712
            :..:|...   :..:...|..|.||:.||.|||..|:|..|:     |.:.||..:|..|.:.|:
 Worm   371 NINELTAQGNCKFGMNDLLCVPFQRLTKYPLLLKELQKKTDLASPDRKSLEEAVEVMEDVCNYIN 435

  Fly   713 Q-------VKRKQEQQSRVKELSGILDGWLGP--ELTVLGELRQEGLLMEQHN--KQRLVLLFAT 766
            :       :|...|.:..:.:||..|:..|..  .:.:.||::.....:.|..  |||.:.||..
 Worm   436 EESRDTNAIKVIDEIEQSITDLSMPLNVKLHDYGRVNLDGEVKMAESTLTQAGKPKQRYIFLFDK 500

  Fly   767 MLIITK-------QKEDG-RLQFKTYISQNNLMLSEHLPGEPTSF-------------YVIPFDE 810
            ::::.|       .|..| ..:..|:..:|..::||....:..|.             |||    
 Worm   501 VIVVCKAANKVMAAKTTGASARTNTFTYKNAYVMSELTIDKNASLDVKSGGTITRRTQYVI---- 561

  Fly   811 PRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWS-LHSGS 874
                  :..|:|::....||                  |.:...||    ..|:.|..: |.|.|
 Worm   562 ------IMTRDRNENNEITQ------------------LTFYFKNE----ATRNNWMTALLLSKS 598

  Fly   875 NSTPT-YLERRNACRRSEIRQRNSKFK----RKTVANSSSFD-----------------SFNESL 917
            |.:|| ||           |..|.|..    |..|.|.::.|                 |.|.|:
 Worm   599 NVSPTDYL-----------RDTNHKVAFHSFRVDVKNPATCDVCDKLMKGLQYQGYKCESCNMSM 652

  Fly   918 EQEEESISQAKPSKPLARNNSLDDTALQKLAAAMRYR----KRDAAVKEETKTPVKEPCKCDQDA 978
            .:|...:.:.:     |...|..:|...:.....|.|    :.|..|.....||  ......|.|
 Worm   653 HKECLGLKKCE-----AVRKSTHETRSSQSFNCNRPRFHIHEGDIVVANSNSTP--SDLSYLQFA 710

  Fly   979 KQDERIEP---------CSCILRDQR--------------------------------SRSAKSQ 1002
            |.| |||.         ..|::.::.                                .|..:::
 Worm   711 KGD-RIEVIKMQGHNRFTGCLINNRNRTGLVHLDHVSQSRTTSMIGLSPIDSPAGSIAPRVVRNE 774

  Fly  1003 SPVFSYKALKE---RSKSVPRIGGFSLDEEAEREREQDEDSAASLRGSKPDLSERK----TKGKG 1060
            |.|...|.|.:   ||.|.|           ...|.....|::::.||...:..::    |:...
 Worm   775 STVLPNKLLSDGSSRSLSGP-----------HGSRSSRNSSSSTINGSMDSVPRQQDYVNTEISE 828

  Fly  1061 FF----EVKQYNHKTMPKKIAN------LKKQRSSTTKSCSRFYMD-----LSEFDSSSSTVLK- 1109
            |.    |:::...::..|...|      ..|.|..|..|.|  |.:     :.|.:|.....|. 
 Worm   829 FLWYMGEMERAKAESTLKGTPNGTFLVRYSKNRKQTAISLS--YKNDVKHMIIEQNSDGKVYLDE 891

  Fly  1110 --ITESTEEL----RPDGEIELAQEAATLDESTQDQY-----YSPDHETELLSPAEKSK------ 1157
              |..||.||    |.:..||:   .|.||...::.|     :...|:.:..||..:.|      
 Worm   892 DYIFNSTVELVQYYRSNNLIEI---FAALDTCLKNPYSQCKVFKAVHDYDAPSPNNEGKFLSFKT 953

  Fly  1158 RDAQIVLDLL----------KNSK------EFERIYNKQQKRRESPVSPVS 1192
            .|..::||.:          .|:|      .:.:.|:...:...|||:|.|
 Worm   954 GDIVVLLDTVGEDRGWWKGQVNNKSGFFPLSYVKPYDPATEGSSSPVTPTS 1004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GEFmesoNP_788403.2 RhoGEF 548..713 CDD:279015 53/192 (28%)
PH_PLEKHG1_G2_G3 694..839 CDD:270063 35/181 (19%)
vav-1NP_001359918.1 CH 38..149 CDD:237981 10/33 (30%)
RhoGEF 241..435 CDD:238091 53/197 (27%)
PH_Vav 453..602 CDD:269930 36/180 (20%)
C1 616..657 CDD:237996 8/40 (20%)
SH3 693..746 CDD:388381 11/55 (20%)
SH2_Vav_family 825..925 CDD:198193 24/104 (23%)
SH3 927..987 CDD:214620 9/59 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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