DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and uig-1

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001256489.1	Gene:	uig-1 / 179808	WormBaseID:	WBGene00009337	Length:	972	Species:	Caenorhabditis elegans

Alignment Length:	900	Identity:	237/900 - (26%)
Similarity:	378/900 - (42%)	Gaps:	186/900 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 ELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAEL 451
            :|||.: ..::..|::.:.:..||  :|       .:.||.|...|:.....|::
Worm   152 KLIEPL-PMIITPPVLMARTQCCA--VC-------YKEKSTGYSVSSRTQSYPLE---------- 196

  Fly   452 EEANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSS--SSSGSDQLLNG----- 509
                .:|:.:.||.|:   :..||||.::       ||:...|..||  ||.|.|:..|.
Worm   197 ----AMSSVTTDRSTE---EETARLSFVS-------SSTGYSSARSSLRSSDGGDESNNNSAGNR 247

  Fly   510 -KLMATSYLASVESLAESENEL--GDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGY---L 568
             ..::.::..|.:|.|.....|  |...|      |::..:|::|:||::||||..|||||   |
Worm   248 DSAISNTFSLSSQSSARRSALLTKGSLTH------LDRIAIELLDTERTYVEDLNAVIKGYMDFL 306

  Fly   569 QDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTS 633
            .:.:|:..:.:|.:..||..||.|:.||..|..:|.....|..:::|||::....|:.|..|||:
Worm   307 VEDREKLKVTLDAISSLFGCIERIFAFNKQLYNQLDAADLDCVKMSRCFVESSGKFEDYIEYCTN 371

  Fly   634 YPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC------ 692
            |...:|.|..|.|.......|...|..|.|.|.|.:||||||||||||||.|:::.|:.
Worm   372 YHRMMSTLYHLQQQPLVARALQERQLALNHSLQLSAYLLKPVQRILKYHLFLENILKNMPSTTHP 436

  Fly   693 -DVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPE-----LTVLGELRQEGLL 751
             ::.:|..||.:|...|..|:..|:|.|...||.:|...|..|...|     |:..|:|..|...
Worm   437 EELIQVKRAHEVMTSQAARINDEKKKAEHIERVGQLQSTLQKWKADEIQISNLSAYGDLLLEATF 501

  Fly   752 MEQHNK-QRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHL-PGEPTSFYVIPFDEPRHQ 814
            .:..:| .||:.||..||:|.||: ......|.||..:||||:|.: |.||.||.|:.||.||.|
Worm   502 RQAGSKTTRLLFLFEEMLLIVKQR-GANYVCKDYIMCSNLMLNEWICPEEPLSFQVLSFDNPRAQ 565

  Fly   815 IKLTARNRDQKRIWTQHIKGVMLE--KLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNST 877
            ....|.:.:|||.|.|.:|.:||:  .::||.:.|:|:..:.|.......|..:...........
Worm   566 YVFMASSMEQKRTWMQELKRMMLDHYSVEIPEKTKQLMLSIDNTRIVPFGRPEFAEVSMKNHKKV 630

  Fly   878 PTYLERRNACRRSEIRQRNSKFKRKTVANS----SSFDSFNESLEQEEES--------ISQAKP- 929
            |.|||:    ||..:..:....:|::::.|    .|..|.:|.:::|::.        .:.|.|
Worm   631 PKYLEK----RRKSVDAKEESNRRRSLSASRLLGGSKTSISEPIKEEQKCTCHMNGGIYNGANPT 691

  Fly   930 -SKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEE---TKTPVKEPCKCDQ----DAKQDERIEP 986
             ||.:..:.||            .|::.......:   .:.||   |:...    |..|....||
Worm   692 TSKSIISHPSL------------TYQQSHPTQSTDPNYCRPPV---CRTQSAATIDLNQVHITEP 741

  Fly   987 CSCILRDQRSRSAKSQSPVFSYKALKE-RSKSVPRIGGFSLDEEAEREREQDEDSAASLRGSKPD 1050
            .|..:...|||..::::.....:..:| ||.|..|:|    :||.:|..:|
Worm   742 NSAAVMSSRSRYQQARNRRLPPRHNQESRSTSSRRMG----EEEIDRTFDQ-------------- 788

  Fly  1051 LSERKTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVLKIT---- 1111
            |.|         |:..:...|.|...:|    ||...:|           ::..|||..||
Worm   789 LYE---------ELVSFGDSTKPTVTSN----RSQRLRS-----------EAPQSTVTTITVAAT 829

  Fly  1112 --ESTEELRPDGEIELAQEAAT-LDESTQDQYYSPDHETELLSPAEKSKRDAQIVLDLLKNSKEF 1173
              .:|..:.......|..::.| |||          :|.|.:|.....:|....|..|.|.|:::
Worm   830 PATATLSIAECANTRLRSKSLTRLDE----------YEAEPISLKPSIERRYSKVDQLKKRSRKY 884

  Fly  1174 ERIYNKQQKRRESPVSPVSPDISRGPIL----------PPPRPPSRSPPPLELEE 1218
                  |..:.......:.|.:.|..:.          |..|...|...||..::
Worm   885 ------QVNQEPEAADVLRPSVGRFSLTDHEIIIHGEEPYKRSSGRQRTPLTAQQ 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	67/174 (39%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	57/153 (37%)
uig-1	NP_001256489.1	RhoGEF	280..458	CDD:214619	67/177 (38%)
uig-1	NP_001256489.1	PH_PLEKHG1_G2_G3	439..590	CDD:270063	57/151 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167728
Domainoid	1	1.000	114	1.000	Domainoid score	I3829
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004049
OrthoInspector	1	1.000	-	-		oto19904
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45924
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X3795
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.970