Protein Alignment GEFmeso and Mcf2l

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_006253478.1
• Gene: Mcf2l / 117020
• RGDID: 619782
• Length: 1280
• Species: Rattus norvegicus
• Alignment Length: 1176
• Identity: 241/1176 - (20%)
• Similarity: 401/1176 - (34%)
• Gaps: 368/1176 - (31%)

  Fly    90 SDDQSASYTLASSSTHLGHQEPPAPLVVAGLRDEPDGAQLSRLVQRRSQESQIHGSSSSIASSGS 154
            :|.||.|..|::      |.|..|.:        .:..||:........||.....:.||..|.:
  Rat   331 NDVQSTSLVLSA------HTEKKAKV--------KEDLQLALTEGNSILESLREPLAESIVHSVN 381

  Fly   155 SRRGSNIRILSPNVHRIITHSDIQPVEAVSAEALKQHQQQSQRSPTQGRYIKTGHSGTPPAAGSA 219
            ..:..|    ...|.|::|  .:...||...|...:|||:.::.
  Rat   382 QDQLDN----QATVKRLLT--QLNETEAAFDEFWAKHQQKLEQC--------------------- 419

  Fly   220 PKLKLSHIPLSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKPQDEDRTPTNKSVPGTP 284
              |:|.|........|.:..|.|:.::.|......|..|.....:.:..:::.....:|:
  Rat   420 --LQLRHFEQGFREVKTALDSMSQKIAAFTDVGNSLAHVQHLLKDLTTFEEKSSVAVDKA----- 477

  Fly   285 FHFDGHPFQGRKLTLPRYDSQQSIKLIEMEQLAATSAQLLHAKPATPGTPATPTPSATKAKEFVC 349
                      |.|:|   :.||   |||....|..|   :|.|              .:..:.:|
  Rat   478 ----------RALSL---EGQQ---LIENRHYAVDS---IHPK--------------CEELQHLC 509

  Fly   350 SEPLSPVDIVDTINFDLVAQHMERLTL-------ADPGDLDPRAELIEAVNKTLVNKPLVRSSSA 407
            ....|.|    |...||:::.:|..:|       :|.|..            .|.::|:.:..|.
  Rat   510 DHFASEV----TRRRDLLSKSLELHSLLETSMKWSDEGIF------------LLASQPVDKCQSQ 558

  Fly   408 ACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAE------LEEANKLSAE-----S 461
            .                   ||:|:         |...|:..|      ::|.||:..|     :
  Rat   559 D-------------------GAEAA---------LQEIEKFLETGAENKIQELNKIYKEYECILN 595

  Fly   462 LDRLTDIKPKF-------------AARLSELARLNNRPL----------------SSSSICSTSS 497
            .|.|..::..|             .|.|.:||....||:                |..|..|:.:
  Rat   596 QDLLEHVQKVFQKQESTEEMFHRRQASLKKLAAKQTRPVQPVAPRPEALTKSPSPSPGSWRSSEN 660

  Fly   498 SSSSGSDQLLNGKLMATSYLASVESLAESE----NELGDQHHPPAMSVLEKTCL-EIVDSERSFV 557
            |||.|:      .|....|..:...::|..    :..|::..  ::::|.:..: |::|:||::|
  Rat   661 SSSEGN------ALRRGPYRRAKSEMSEPRQGRTSSTGEEEE--SLAILRRHVMNELLDTERAYV 717

  Fly   558 EDLGQVIKGYLQDWKERACLRV------DELQILFANIEEIYEFNSMLLQRLINTGRD-PGRIAR 615
            |:|..|::||..:........:      ::..|||.|:||||.|::.:..|.:.:..| |..:.|
  Rat   718 EELLCVLEGYAAEMDNPLMAHLISTGLQNKKNILFGNMEEIYHFHNRIFLRELESCIDCPELVGR 782

  Fly   616 CFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILK 680
            ||::..:.|.:|..||.:.|.:.||..:....    ......||.|.|:|.|.||||||||||.|
  Rat   783 CFLERMEEFQIYEKYCQNKPRSESLWRQCSDC----PFFQECQKKLDHKLSLDSYLLKPVQRITK 843

  Fly   681 YHLLLDSL---RKHCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGIL----------- 731
            |.|||..:   .|||:..|                      :.|..:..:.|||
  Rat   844 YQLLLKEMLKYSKHCEGAE----------------------DLQEALSSILGILKAVNDSMHLIA 886

  Fly   732 ----DGWLGPELTVLGELRQEG--LLMEQHNK--------------QRLVLLFATMLIITKQKED 776
                ||.||.    ||:|..:|  .:...|.|              ||.:.|....::..|::|:
  Rat   887 ITGYDGNLGD----LGKLLMQGSFSVWTDHKKGHTKVKELARFKPMQRHLFLHEKAVLFCKKREE 947

  Fly   777 G--------RLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIK-LTARNRDQKRIWTQHI 832
            .        ...:|..::...:.::|::.|:...|.:  :...|.::. :.|...:.|..|...|
  Rat   948 NGEGYEKAPSYSYKQSLNMTAVGITENVKGDTKKFEI--WYNAREEVYIIQAPTPEIKAAWVNEI 1010

  Fly   833 KGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERR-------NACRRS 890
            :.|:..:|.....|.:  ::...:....|..:....|...||......||.|       ..|..|
  Rat  1011 RKVLTSQLQACREASQ--HRALEQSHSLPLPTPASTSPTKGSTRNVKKLEDRKTDPLCLEGCVSS 1073

  Fly   891 EIRQRNSKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKPLARNNSLDDTALQKLAAAMRYRK 955
            .:.:...|.|...|.:|:|          |..::|:.:             ..||.||
  Rat  1074 SLPKPPEKGKDDAVPSSTS----------ESSALSRKR-------------FTLQGLA------- 1108

  Fly   956 RDAAVKEETKTPVKEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSV-- 1018
                   ..|.....|...|:.||:.|                .||....|..:...:.|.|:
  Rat  1109 -------NLKGQKASPTSPDKKAKRHE----------------VKSDPTPFGLRGWSKTSHSLEA 1150

  Fly  1019 -PRIGGFSLDEEAEREREQDEDSAASLR-------------------------GSKPDLSERKTK 1057
             ...||:|..||.....:.:||.....|                         |...::.|..|:
  Rat  1151 PEEDGGWSSAEELINSSDAEEDGGVGPRKLVPGKYTVLMDGEKGGSDTLAMRSGDMVEVVEEGTE 1215

  Fly  1058 GKGFF-EVKQYNHKTMP-KKIANLKKQRSSTTKSCSRFYMDLSEFDSS-SSTVLKITESTEELRP 1119
            |..:. ::.......:| ..:|.|..:.||.  .|      ||..||| .|.||..:.|..|..|
  Rat  1216 GLWYVRDLTSSKEGWVPASSLATLLGKSSSA--QC------LSSSDSSPGSAVLSNSSSCSEGYP 1272

  Fly  1120 DGEIEL 1125
            ....||
  Rat  1273 TPFSEL 1278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	57/173 (33%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	30/184 (16%)
Mcf2l	XP_006253478.1	SEC14	145..290	CDD:214706
		SPEC	421..623	CDD:238103	48/283 (17%)
		RhoGEF	702..879	CDD:238091	61/202 (30%)
		PH_Dbs	886..1017	CDD:269934	25/136 (18%)
		SH3_DBS	1184..1236	CDD:212791	5/51 (10%)