Protein Alignment GEFmeso and ARHGEF25

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_001104740.2
• Gene: ARHGEF25 / 115557
• HGNCID: 30275
• Length: 619
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 135/570 - (23%)
• Similarity: 216/570 - (37%)
• Gaps: 148/570 - (25%)

  Fly   485 RPLSSSSIC-STSSSSSSG-----SDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVL- 542
            |.|..|..| |..:.:.||     .:.:|...|.....|..:..|.......||:..||....|
Human   119 RWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLS 183

  Fly   543 ---------EKTCL--------EIVDSERSFVEDLGQVIKGYLQDWKERACLRVDEL-----QIL 585
                     :|..|        |:|::|:.:|:||||:::||:   ...|...|.|.     :|:
Human   184 QAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM---ATMAAQGVPESLRGRDRIV 245

  Fly   586 FANIEEIYEFN-SMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATH 649
            |.||::|||:: ...||.|....:||..:|:.||.......:|..||.:.|::..::::...
Human   246 FGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGD--- 307

  Fly   650 TYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKH--------CDVKEVVEAHVIMRQ 706
              |.....::.|.|||.|...|:||||||:||.|||....|:        .|:::.||....:
Human   308 --SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV-- 368

  Fly   707 VAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGEL----------RQEGLLMEQHNKQRLV 761
                   .||..:..:     .|.|.|:.| :||..|:|          .:.|.|:....::|.|
Human   369 -------PKRCNDMMT-----LGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRV 420

  Fly   762 LLFATMLIITKQKEDG-------RLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIK--- 816
            .||..::|.::....|       ...:|..|..:.|.|..:|.|:|..| .:....|...|:
Human   421 FLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRF-ALTSRGPEGGIQRYV 484

  Fly   817 LTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYL 881
            |.|.:....:.|.:|:..::..:.|. :.|.:                            :|...
Human   485 LQAADPAISQAWIKHVAQILESQRDF-LNALQ----------------------------SPIEY 520

  Fly   882 ERRNACRRSEIRQRN------SKFKRKTVANSSSFDSFNESLEQEEESISQAKPSKPLARNNS-- 938
            :||.:...|..|.|.      .:.:....|..|:....|.||           ||..|:....
Human   521 QRRESQTNSLGRPRGPGVGSPGRIQLGDQAQGSTHTPINGSL-----------PSLLLSPKGEVA 574

  Fly   939 -----LDDTALQKLAAAMRYRKRDA-AVKEETKTPVKEPC-----KCDQD 977
                 ||..||..:..|    ..|: .|....|||   ||     |.|:|
Human   575 RALLPLDKQALGDIPQA----PHDSPPVSPTPKTP---PCQARLAKLDED 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	54/177 (31%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	34/164 (21%)
ARHGEF25	NP_001104740.2	RhoGEF	203..373	CDD:459876	56/186 (30%)
		PH2_Kalirin_Trio_p63RhoGEF	378..520	CDD:270061	33/172 (19%)