Protein Alignment GEFmeso and Arhgef7

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_008769602.3
• Gene: Arhgef7 / 114559
• RGDID: 620624
• Length: 901
• Species: Rattus norvegicus
• Alignment Length: 897
• Identity: 178/897 - (19%)
• Similarity: 329/897 - (36%)
• Gaps: 213/897 - (23%)

  Fly   371 MERLTLADPGDLDP--------RAELIEAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTK-- 425
            :|||.   ||.::.        :.:....|..:||....|.:.....:.::|:.|  :..|.|
  Rat   113 LERLL---PGTIEKTFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARP--SSHRIKSF 172

  Fly   426 -SLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTD---IKPKFAARLSELARLNNRP 486
             |||:::|            ..:.::|.::...|.:..|....   ::.||     ...:.|...
  Rat   173 DSLGSQSS------------HSRTSKLLQSQYRSLDMTDNANSQLVVRAKF-----NFQQTNEDE 220

  Fly   487 LSSSS---ICSTSSSSSSGSDQLLNGKLMATSYLAS--VESLAESENEL----GDQHHPPA---M 539
            ||.|.   |..|........:...||:   |.:..|  |..:..||..:    |....||.   .
  Rat   221 LSFSKGDVIHVTRVEEGGWWEGTHNGR---TGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDT 282

  Fly   540 SVLEKTCLEIV-----DSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSML 599
            :.:.|:...:|     ::|..:.::|..|:..||...:....|.......|..|:|||..|..:|
  Rat   283 TAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVL 347

  Fly   600 LQRLINTGRDP---GRIARCFIDLRDGF-DVYTTYCTSYPEAISLLTKLLQATHTYSL------- 653
            :|.|....:.|   .|:..||:.|.... .:|..||.::|.|:|:||:     |:..|
  Rat   348 VQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTE-----HSEDLGEFMETK 407

  Fly   654 LASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC-----DVKEVVEAHVIMRQVAHNIDQ 713
            .||:..:    |.|.:.|.||..|:.||..||..|.:|.     |.:::.::....:.::....:
  Rat   408 GASSPGI----LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQE 468

  Fly   714 VKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLM-----EQHNKQRLVLLFATMLIITKQ 773
            |::::|.:.::  |:..:..|.|.::..||.:.....:.     .:...:|.:|||..:|::...
  Rat   469 VRKRKELELQI--LTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSA 531

  Fly   774 KEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIP--FDEPRHQIKLTARNRDQKRIWTQHIKGVM 836
            ..    :...:|.|..|         ||:...|.  .|...|      ||..:       |.|.|
  Rat   532 SP----RMSGFIYQGKL---------PTTGMTITKLEDSENH------RNAFE-------ISGSM 570

  Fly   837 LEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKR 901
            :|:         ::....|::|      ..:|..|                           .:|
  Rat   571 IER---------ILVSCNNQQD------LHEWVEH---------------------------LQR 593

  Fly   902 KTVANSSSFDSFNESLEQEEESISQAKPSKPLARNNSLDDT-------ALQKLAAAMRYRKRDAA 959
            :|...|.|    |.:::..... |...||.||..::...|:       |...|.....:......
  Rat   594 QTKVTSVS----NPTIKPHSVP-SHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTT 653

  Fly   960 VK----EETKTPVKEPCKCDQDAKQDERIEPCSCI-LRDQRSRSAKSQSPVFSYKALKERSKSVP 1019
            :.    |..|||......|.:.|..   :.|.:.: .::..|||.|:...:.. |...||..|
  Rat   654 ISWGPLEPPKTPKPWSLSCLRPAPP---LRPSAALCYKEDLSRSPKTMKKLLP-KRKPERKPS-- 712

  Fly  1020 RIGGFSLDEE--AEREREQDEDSAASLRGSKPDLSERKTK--------GKGFFEVKQYNHKTMPK 1074
                   |||  ..:.....|:.|..|:..:...:..||:        |...    .:||.....
  Rat   713 -------DEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDL----MHNHVLADD 766

  Fly  1075 KIANLKK--QRSSTTKSCSRFYMDLSEFDS----SSSTVLKITESTEELRPDGEIELAQEAATLD 1133
            ..::|..  :|||.::.......:.||:||    .|..:...:.|.:|..|  ::.|.:|...:.
  Rat   767 DQSSLDSLGRRSSLSRLEPSDLSEDSEYDSLWTAHSYRMGSASRSRKESAP--QVLLPEEEKIIV 829

  Fly  1134 ESTQDQYYSPDHETELLSPAEKSKRDAQIVLDLLKNSKEFERIYNKQQKRRE 1185
            |.|:....:...|..|:......|.:.|   :|.:::|:.::...::|:.|:
  Rat   830 EETKSNGQTVIEEKSLVDTVYALKDEVQ---ELRQDNKKMKKSLEEEQRARK 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	46/184 (25%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	25/151 (17%)
Arhgef7	XP_008769602.3	None