| Sequence 1: | NP_788403.2 | Gene: | GEFmeso / 37134 | FlyBaseID: | FBgn0050115 | Length: | 1549 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_006104.4 | Gene: | VAV3 / 10451 | HGNCID: | 12659 | Length: | 847 | Species: | Homo sapiens |
| Alignment Length: | 840 | Identity: | 170/840 - (20%) |
|---|---|---|---|
| Similarity: | 304/840 - (36%) | Gaps: | 234/840 - (27%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 460 ESLDRLTDIKPKFAARLSELARLNNRPLS-SSSICSTSSSSSSGSDQLLNGKLMATSYLASV--E 521
Fly 522 SLAESENELGD-------------------QHHPPAM--SVLEKTCL-EIVDSERSFVEDLGQVI 564
Fly 565 KGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINT--GRDPGRIARCFIDLRDGFDVY 627
Fly 628 TTYCTSYPEAISLLTKLLQATHTYSL-LASTQKLLQH-RLPLGSYLLKPVQRILKYHLLLDSLRK 690
Fly 691 H-------CDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQE 748
Fly 749 GLL----MEQHNKQ-RLVLLFATMLIITKQKEDGR-----LQFKTYISQNNLMLSEHLPGEPTSF 803
Fly 804 YVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKW 868
Fly 869 SLHS---------------------------GSNSTPTYLERRNACRR-SEIRQRNSKFKRKTVA 905
Fly 906 NSSSFDSFNESLEQEEESISQAKPSKPLARNNS----------------LDDTA--LQKLAAAMR 952
Fly 953 YRKRDAAVKEETKTPVKEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKS 1017
Fly 1018 VPRIGGFSLDEEAEREREQDEDSAASLRGSKPDLSERKTKGKGFFEVK-QYNHKTMPKK------ 1075
Fly 1076 ---IANLKKQRSSTTKSCSRFYMDLSEFDSSSSTVLKITESTEELRPDGEIELAQEAATLDESTQ 1137
Fly 1138 DQYYSPDHE---------TELLSPA---------EKSKRDAQIVLDLLKNSKEFERIYNK 1179 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| GEFmeso | NP_788403.2 | RhoGEF | 548..713 | CDD:279015 | 46/175 (26%) |
| PH_PLEKHG1_G2_G3 | 694..839 | CDD:270063 | 32/154 (21%) | ||
| VAV3 | NP_006104.4 | CAMSAP_CH | 18..103 | CDD:288798 | 4/8 (50%) |
| RhoGEF | 193..369 | CDD:238091 | 48/180 (27%) | ||
| PH_Vav | 383..506 | CDD:269930 | 26/141 (18%) | ||
| PH | 407..502 | CDD:278594 | 21/112 (19%) | ||
| C1 | 514..561 | CDD:237996 | 4/46 (9%) | ||
| Sufficient for interaction with ROS1. /evidence=ECO:0000269|PubMed:11094073 | 560..847 | 65/342 (19%) | |||
| SH3_VAV3_1 | 596..657 | CDD:212914 | 11/73 (15%) | ||
| SH2_Vav3 | 666..768 | CDD:198270 | 27/144 (19%) | ||
| SH3_VAV3_2 | 791..846 | CDD:212911 | 9/33 (27%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1291 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.940 | |||||