Protein Alignment GEFmeso and plekhg1

DIOPT Version :9

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_021325545.1
• Gene: plekhg1 / 101886810
• -ID: -
• Length: 1513
• Species: Danio rerio
• Alignment Length: 1216
• Identity: 279/1216 - (22%)
• Similarity: 480/1216 - (39%)
• Gaps: 316/1216 - (25%)

  Fly   473 AARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATS-------------YLASVESLA 524
            ::|..:....::||:|..|  ::||:||..|...|.|:.:..|             .|.....|.
Zfish    42 SSRSMDSTHCSDRPVSYGS--TSSSASSRDSHCSLGGRPVLGSTPERDRDSGAIRLELVPARQLE 104

  Fly   525 ESE----------NELGDQHHPPAMSV--LEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACL 577
            |.|          |:..:...|....|  :::...||:::|:::|:||..:::.||.....::.|
Zfish   105 EEEESGRKTRKLTNQDAEIQSPEGRKVQYVDRVVEEILETEKTYVQDLRSIVQDYLDCISNQSLL 169

  Fly   578 RV--DELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISL 640
            .:  :|...||.||.:||.|||.||:.|.....:|..||:||:...:.|.:||.|||:||.::::
Zfish   170 LLGDEERNSLFGNIRDIYRFNSELLRDLEKCNANPVAIAKCFVAKSEDFHIYTQYCTNYPRSVAV 234

  Fly   641 LTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCD--------VKEV 697
            ||:.::.......|...|:.|:|.|||||||||||||||||||||..:..|.:        ::|.
Zfish   235 LTECMRNKMVAKFLRERQESLKHSLPLGSYLLKPVQRILKYHLLLHEIATHLEKDSEMYDVIQEA 299

  Fly   698 VEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNK-QRLV 761
            ::.   |::||.:|:.:|||.|...|::|:..:|..|.||:|...|||..||....|..| :|.:
Zfish   300 IDT---MQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLIGYGELVLEGTFRIQRAKNERTL 361

  Fly   762 LLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKR 826
            .||..:|:|||::|: ...:|.:|...||||.|.:|.||.||.|..:..|:.|..:.|:::..|:
Zfish   362 FLFDKLLLITKKREE-TYSYKAHILCCNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKK 425

  Fly   827 IWTQHIKGVMLEK--LDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRR 889
            :|..|:|.::||.  ..||.:||:.:.::......:.:.::....:::....:|..:.|:.....
Zfish   426 MWVLHLKRLILENHPAKIPAKAKQAILEMDTANHPSFNHNSDDKRVNTKEGPSPRRVRRKTEPLS 490

  Fly   890 SEIR-----------QRNSKFKRKTVANSSSFDSFNES---LEQEEESISQAKPS----KPLARN 936
            ..::           |:.|.|....::..:|..|...|   :.:.:||:.....|    :|..::
Zfish   491 KLLKNSKHIISSPDIQKRSSFGVTLLSPVASLGSIGRSRSLVSESQESLDPGDHSDVDDEPNTQD 555

  Fly   937 -NSLDDTALQ--------------------KLAAAMRYRKRD----------AAVKEETKTP--- 967
             :..|||.|.                    .:.:..::|..|          .:::.:..||
Zfish   556 ADDEDDTGLSSGGKLRVPGKGSRKRLNQQVSVDSIEQWRNNDLTHADLQTAKQSLQNKVITPPIL 620

  Fly   968 -VKEPCKCDQDAKQDERIE--------PCSC-ILRDQRSRSAKSQSPVFSYKALKERSKSVPRIG 1022
             |..|.:.|    .||.:.        |..| |..|.|.|.|          ....|.||
Zfish   621 RVTAPPESD----GDEHLRAMLGTGQAPAFCNIWTDHRVRRA----------MFPTRQKS----- 666

  Fly  1023 GFSLDEEAEREREQDEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTM--PKKIANLKKQRSS 1085
             |.:|:        |||.......::.|:|....:.         :|:|.  |::..:...:.:.
Zfish   667 -FQIDD--------DEDIYQMFLPTENDVSSHDAES---------DHETADHPERPCSWHVEPTK 713

  Fly  1086 TTKSCSRFYMDLSEFDSSSSTVLKITESTEELRPDGEIELAQEAATLDESTQDQYYSPDHETELL 1150
            |           |........||:...|..| .|.|: |:..:.:..:|...:|..|..:|....
Zfish   714 T-----------SRLGLPGRGVLRRANSFGE-EPSGQ-EIPTKQSLEEEEINNQTESSSNEISGS 765

  Fly  1151 SPAEKSKRDAQIVLDLLKN---SKEFERIYNKQQKRRES---PVSPVSPDISRGPILPPPRPPS- 1208
            |.||      |:..|.::|   :..||.:......|::.   .|..|.|.|:...|:.|....|
Zfish   766 SSAE------QLTADDIENVYDNISFEELQAMGLIRKDQVNHAVPEVKPMIAPQVIITPTETESS 824

  Fly  1209 ----RSPPPLELEEQEKKPVE--EVDSV-SEEPIYETLLRNVHVPYKFSPVLG----RAKSSQIL 1262
                ||      ..||.:|.|  |:..| :||.:|:|::      ::..||:.    ..|.:.:|
Zfish   825 CGSNRS------SGQEGEPFETCELQIVENEENVYDTIV------FQECPVIAAPSDEGKPANVL 877

  Fly  1263 KKRSKTAPAASRPESDYVTLVYSPEGVLQRVGEEVVQRDSCSSSTTSTSSNGSGSTLKRDSQSTV 1327
                       |.|:|.:        ..|..|..|.:.:.|:.:.|..
Zfish   878 -----------RSEADII--------ATQNSGGFVSEENLCTKTKTDF----------------- 906

  Fly  1328 INLLMEAAQEHESRPLPKNSVSGSESSLLPRALKSID----NLSMAFGRSNRPPER-----RVSD 1383
                     ||...|   :.:..|:.|.....|:.:|    :|.....::.:.|::     .||.
Zfish   907 ---------EHPHVP---SDIETSQLSSADNTLEQVDEIWTDLENYIRKNEKKPDKLPAAFPVSG 959

  Fly  1384 VSEMCRQSVLHRQGSEAVGERMAHVDYADPKALFGLGVLNHSERDSVFSLTSSSSDSMCEQQRKR 1448
            ....|:.....::..::        .:...||        |:.......|....:||.|:.|...
Zfish   960 TDATCKTKDSPKKSCDS--------PHKAQKA--------HNSPSKTSRLQQKDNDSQCKAQESP 1008

  Fly  1449 SGVGATFEYEQQVEDSLENDFRDSAIYSDDNEKRSGDYDVHLRRPSSPPP----PPP-------- 1501
            |...                  :||..|.|:..:.....:.:..|.||.|    |||
Zfish  1009 SKKA------------------NSAQRSSDSPCKLPLKTIPVGTPGSPNPPATKPPPALQIPIIN 1055

  Fly  1502 --------------PLGPRPHQPPQIAPKPS-----KDQLIQQRSG 1528
                          |..|....||...|:|.     :::|.:..||
Zfish  1056 LPESTLDENDGASSPAAPSIPLPPTPEPQPGTVKSIRNKLARLSSG 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	68/174 (39%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	52/145 (36%)
plekhg1	XP_021325545.1	RhoGEF	137..312	CDD:214619	68/177 (38%)
		PH_PLEKHG1_G2_G3	293..438	CDD:270063	52/148 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5341
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910