Protein Alignment GEFmeso and plekhg3

DIOPT Version :9

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_017208169.1
• Gene: plekhg3 / 101886323
• -ID: -
• Length: 1467
• Species: Danio rerio
• Alignment Length: 1340
• Identity: 321/1340 - (23%)
• Similarity: 516/1340 - (38%)
• Gaps: 360/1340 - (26%)

  Fly   430 KASTLGGGVPIKLPTAEQLAELEEANKLSAESL---DRLTDIKPKFAARLSELARLNN--RPLSS 489
            |:.::...||:.          ||:.:||..||   ||.:      ...||:.:...:  ||:|.
Zfish     4 KSQSMAHDVPMG----------EESPRLSIASLGSNDRSS------ITTLSDCSDFTDVQRPVSV 52

  Fly   490 SSICSTSSSSSSGSDQLLNGKLMATSYLASVE----------------SLAESENELGDQHHP-- 536
            .|..| |.|.||..|..|:|.:.|.   ..:|                :|.::.:....|:..
Zfish    53 VSNIS-SGSGSSRDDVPLSGVVSAA---VPIEDNVDLELTPAANPTEPNLTQTSSHFLQQNSSNT 113

  Fly   537 ------------------PAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQ 583
                              |.::.|::..:||:::||.:|.||..:::.||....:...|.:...|
Zfish   114 VNNNTSFSPFAANTMAPNPELTYLDRVVMEIIETERMYVRDLRSIVEDYLAHIIDTGDLPIKPEQ 178

  Fly   584 I--LFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQ 646
            :  ||.|||:||||||.|||.|.....||..|||||:...:.||:||.|||:||.:::.||..::
Zfish   179 VCALFGNIEDIYEFNSELLQSLDMCDSDPVAIARCFVIKSEYFDIYTQYCTNYPNSVAALTDCMR 243

  Fly   647 ATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKE-----VVEAHVIMRQ 706
            ...........|..|:..|||||||||||||||||||||..:.||.|.:|     |.||...|..
Zfish   244 NKTLAKFFRERQATLKRSLPLGSYLLKPVQRILKYHLLLQEIAKHFDPQENGYEVVEEAIYTMTG 308

  Fly   707 VAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEG-LLMEQHNKQRLVLLFATMLII 770
            ||..|:.:|||.|...|::|:..:|..|.||:||..|||..|| ..:.:...:|.:.||..||:|
Zfish   309 VAWYINDMKRKHEHAVRLQEVQSLLINWKGPDLTTYGELVLEGSFRIHRAKNERTLFLFDRMLLI 373

  Fly   771 TKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGV 835
            ||::.: ...:||:||.:.|||.|... :...|.|..:..|:....:.||..::|::|..|||.:
Zfish   374 TKRRGE-HYVYKTHISCSTLMLIESAK-DSLCFSVTHYKHPKQPHTVQARTLEEKKLWAHHIKRL 436

  Fly   836 MLE--KLDIPMRAKELVYQLGNEEDR---TPDRSTWKWSLHSGSNSTPTYLE-------RRNACR 888
            ::|  :..||.:|||.:.::.:...:   :|:|  .|.|:...|.....:.:       .:.|.:
Zfish   437 IIENHQAVIPQKAKEAILEMDSIYKKYRYSPER--LKKSVSCQSEEFSNFRQGLKQPEASKEALK 499

  Fly   889 RSEIRQRNS---------KFKRKTVANSSSFD------SFNESLEQEEESISQAKP---SKP--- 932
            .::..|::|         |:..:...:.||.|      |..|:..|||.|:....|   .:|
Zfish   500 STKAMQKHSDIEAPMEADKWPLQATDSVSSADLGLCESSAEETDAQEEYSLKAFIPGDNEEPVHI 564

  Fly   933 --------------------------LARNNSLDDTALQKLAA--AMRYRKR-----DAAVKEE- 963
                                      |..:|.:.|.|...|||  ...||.|     |.|::||
Zfish   565 MPSVKGRLIREDEDEAEAGESDSDNILMEDNQVADFASSMLAAISCWHYRARALLSMDFAMEEEG 629

  Fly   964 ----TKTPVKEPCKCDQDAKQDERIEPC----SCILRDQRSRSAKSQSPVFSYKALKERSKSVPR 1020
                ..|..||      :....|:::.|    .||....:|:..|..|...:....||.:...|.
Zfish   630 CAFPENTFKKE------NKPSAEQVKACLKDEKCIFEQDKSQHLKMTSCWGTTDKTKEDTFCDPE 688

  Fly  1021 ---IGGFSLD-EEAEREREQDEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKT-MPKKIANLK 1080
               :....|| .|.|...:||:     |:|.|.:...||:          :.|:. .|.:  :.:
Zfish   689 PIDVHQHVLDIREMESAIDQDD-----LKGPKKEREARKS----------FLHQNDTPGE--SSE 736

  Fly  1081 KQRSSTTKSCSRFYMDLSEFDSSSS-------TVLKITESTEELRPDG----------------- 1121
            .:..:..|..|...:..|..|.:|:       |..:|:.||::.|..|
Zfish   737 DEEDTEEKPGSTSILPSSVLDQASAIAEHFVCTARRISISTDDARSPGCPSPHLPSRTGSTLSLR 801

  Fly  1122 -----------------EIELAQEAA-----TLDESTQDQYYSPDHETELLSPAEKSKRDAQIVL 1164
                             |..|.||..     |:..|.:|..:..|........:..|.:| |:::
Zfish   802 DPLEHQHRLTSTYSDSCESPLTQENLASVDFTIGSSVEDGLFDCDRSICRRRDSVLSTQD-QLLI 865

  Fly  1165 DLLK----NSKEFERIYNKQQKRRES----PVSPVSPDISRGPILPPPRPPSRSPPPLELEEQEK 1221
            ..::    |::..:..::  .|||||    |...|...:||...:|..:..:     ||...:..
Zfish   866 SKIRSYYENAEHQDATFS--LKRRESLSYIPSGLVRNSVSRLNSIPKDKGLA-----LETTVRTF 923

  Fly  1222 KPVEEVDSVSEEPIYETLLRNVHVPYKFSPVLGRAKSSQILKKRSKTAPAAS------------R 1274
            :|.::..| |.:.:::|            ..|..|.||....::.:...:||            :
Zfish   924 EPDKDCAS-SMQSLFDT------------TALSEATSSANSSRQEQPVVSASTNPTGFNVDGSVK 975

  Fly  1275 PESDYVTL------VYSPEGVLQRVGEE-----------------------------VVQRDSCS 1304
            |:|.|:..      |:.|...:.:|.::                             :::||...
Zfish   976 PQSTYIQAESEQNEVFHPSSEMIKVWQDMEREVTRCQGDVKALVPRGNPYFRGICPNLIRRDPNQ 1040

  Fly  1305 SSTTSTSSNGSGSTLKRDSQSTVINLLMEAAQEHESRPLPKNSVSGSESSLLPRALKSIDNLSMA 1369
            ...|....| .|.....||..:.|                      .|.|..|..|...:| |.|
Zfish  1041 DEKTEAKGN-KGLIAFEDSDLSTI----------------------KEESFTPSPLIEKEN-SEA 1081

  Fly  1370 FGRSNRPPERRVSDVSEMCRQSVLHRQGS--EAVGERMAHVDYADPKALFGLGVLNHSERDSV-- 1430
            ..|            ::..||....::|.  .|:..|:..: .|:.:...|.|..:..:.||.
Zfish  1082 ISR------------NDAIRQKQWQKEGRLLSALAPRVIQL-RAESEYERGTGAQSAEDGDSAQS 1133

  Fly  1431 --------FSLTSSSSDSMCEQQRKRSG-VGATFEYEQQVEDSLENDFR---DS----AIYSDDN 1479
                    :|.....:..|..|:.:.|| .|.|......|.|....:.:   ||    |.|  |.
Zfish  1134 KVLNLARKYSQRIKCTQPMLRQRSQESGETGLTKRNMLSVVDEKPEEVKGKPDSMPSMAPY--DQ 1196

  Fly  1480 EKRSGDYDVHLRRPSSPPPPPPPLGPRPHQPPQIAPKPSK 1519
            ..|..|.:..| .|.||...|.|  |.....|.:....||
Zfish  1197 ADRDRDQEAQL-MPLSPARSPTP--PEKFNWPDVRELRSK 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	78/171 (46%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	52/152 (34%)
plekhg3	XP_017208169.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45924
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100