DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and Plekhg2

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_006539499.1	Gene:	Plekhg2 / 101497	MGIID:	2141874	Length:	1366	Species:	Mus musculus

Alignment Length:	1301	Identity:	303/1301 - (23%)
Similarity:	458/1301 - (35%)	Gaps:	409/1301 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 PKFAARLS--------ELARLNNRPLSSSSICSTSSSSSSGSDQLLN-----GKLMATSYLASVE 521
            ||.:.||.        :.|.:::.|.::.:..:.:|...|||...|:     |........:..|
Mouse    11 PKPSLRLGCGHQGEVCDCAAVSDTPTAAQAATTMASPRGSGSSTSLSTVGSEGDPSPACSASRPE 75

  Fly   522 SLAESENELGDQHHPPA-------MSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKE-RAC-L 577
            .|.|....|   |..|.       .|.||:...|||::||::|.||..:::.||....: ||. |
Mouse    76 PLPEPPIRL---HLLPVGIQGSVKPSRLERVAREIVETERAYVRDLRSIVEDYLGPLMDGRALGL 137

  Fly   578 RVDELQILFANIEEIYEFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLT 642
            .::::..||||||:||||:|.||:.|.... ..|.||.||:...:.||:||.||.:||.:::||.
Mouse   138 NMEQVGTLFANIEDIYEFSSELLEDLEGCS-SAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLR 201

  Fly   643 KLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKH------CDVKEVV-EA 700
            :|..:......|...|..|:|.|||.|:|||||||||||||||..|.||      ...:|:| ||
Mouse   202 ELSVSPPATLWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPDSGGREMVEEA 266

  Fly   701 HVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLM-------EQHNKQ 758
            .|.|..||..|:.:|||||..:|::|:...|.||.||||:..|||..||...       .....:
Mouse   267 IVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGTFRGGGGGGPRLRGGE 331

  Fly   759 RLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRD 823
            ||:.||:.||::.|:: .....:|.:|...||.:|| .|.:|..|.|.....|:|:....|:|::
Mouse   332 RLLFLFSRMLLVAKRR-GPEYTYKGHIFCCNLSVSE-TPRDPLGFKVSDLTIPKHRHLFQAKNQE 394

  Fly   824 QKRIWTQHIKGVMLEK--LDIPMRAKELVYQ-------------------LGNEEDR-----TPD 862
            :||:|...::.:..|.  ..||.:||:::.:                   |.:...|     ||.
Mouse   395 EKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKHIPEPPTSPLDSPRPRDAPGFTPG 459

  Fly   863 R------------------------------STWKWSLHSGSNSTPTYLERRNACRRSEIRQRNS 897
            |                              |.|...|      |..:|....|.....|..:|.
Mouse   460 RRNPAPSPRLSGSRRGRRQSGEYPPLEGDPGSQWPGLL------TSFFLPPEPAKEAYVIFPQND 518

  Fly   898 KFKRKTVANSSSFDSFNE----SLEQEEESISQAKPSKPLARNNSLDDTALQKLAAAMRYRKRDA 958
            |.:.|...:.......:|    |.....|.:..|.|........|:.:..|: |......|....
Mouse   519 KPQVKHAGSEGELHPSSELQPVSASGPPEDLEDAGPPTLDPSGTSITEEILE-LLNQRGLRDSGP 582

  Fly   959 AVKEETKTPVKEPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGG 1023
            |..:..|.|                        ||.|   ...:|....:::|..|..|
Mouse   583 ATHDIPKFP------------------------RDSR---VPVESEPLPFQSLPSRESS------ 614

  Fly  1024 FSLDEEAEREREQDEDSAA------SLRGSK-------PDLSERKTKGKGFFEVKQYNHKTMPKK 1075
               :||.|.:.|.||...:      .|.||.       |.|::                  :|.:
Mouse   615 ---EEEEEEDLETDEREPSPLHVLEGLEGSSAAEIPCIPSLTD------------------IPSE 658

  Fly  1076 IANLKKQRSSTTKSCSRFYMDLSEFD--------SSSSTVLKITE-STEELRPDGE------IEL 1125
            :.:|.:...:....|      ||:..        |.:|||..|.. :|....|.|.      .|.
Mouse   659 VPSLPEIPEAPCLPC------LSDISGVFEVPCLSPTSTVPDIPSLATTPSFPCGSWLPGPLQEA 717

  Fly  1126 AQEAAT------------LDESTQDQYYSPDHETELLS---------------PAEKSKRDAQIV 1163
            ||..||            |.||..:.....:.:||.:|               |.|...|....:
Mouse   718 AQPQATRRELLSGSNPGRLSESPSESREGQEDDTEGVSFSAVQREAGTSVQGFPEELEYRSCSEI 782

  Fly  1164 --------------------LDLLKNS-----------------------KEFERIYN---KQQK 1182
                                |.:|::|                       :|..|:|:   :|.:
Mouse   783 RSAWQALEQGQLARPGFPEPLLILEDSDLRGGSTSGKTGMPHSERSASRVRELARLYSERIQQMQ 847

  Fly  1183 RRESPVSPVSPDISRGP-ILPPPRPPSRSPPPLELEEQEKKPVEEVDSVSEEPIYETLLRNVHVP 1246
            |.|:..|..:|  .|.| :|..|:|   ||.|         |.||.:..:.......|:..:..|
Mouse   848 RAETRASTNAP--RRRPRVLAQPQP---SPCP---------PQEEAEPGALPAFGHVLVCELAFP 898

  Fly  1247 YKFSPVLGRAKSSQILKKRSKTAPAASRPESDYVTLVYSPEGVLQRVGEEVVQRDSCSSSTTSTS 1311
                           |....::.|             ..|..::|......:|.|..|....:.|
Mouse   899 ---------------LNCTQESVP-------------LGPAVLVQAATPLCIQGDDLSGQNLNVS 935

  Fly  1312 SNGSGSTLKRDSQSTVINLLMEAAQEHESRPLPKNS----VSGSESSLLPRALKSIDNLSMAFGR 1372
            .......|..:|....:             |||..|    :....:||||:
Mouse   936 DLSKQGHLSSNSIPPPV-------------PLPGQSNFQNIQVPSTSLLPK-------------- 973

  Fly  1373 SNRPPERRVSDVSEMCRQSVLHRQGSEAVGERMAHVDYADPKALFGLGVLNHSERDSVFSLTSSS 1437
             ..||:.:|...|.:...|.|..|           |..|.|.|         ..|:.| .:...|
Mouse   974 -QEPPDVQVPTASTLPDTSQLQSQ-----------VPAATPSA---------GHRNCV-EIQVQS 1016

  Fly  1438 SDSMCEQQRKRSGVGATFEYEQQVEDSLENDFRDSAIYSDDNEKRSGDYDVHLR----RPSSPPP 1498
            :.|:..|:.:...|..:   :|:..:..:|..:     :...|:|....|..|.    ||.||.|
Mouse  1017 TTSLPGQECQADTVALS---KQEGHEDSQNPNK-----APGAEQRDVSIDQGLAVVGGRPVSPLP 1073

  Fly  1499 -------------PPPPL--------GP----------RPHQPPQIAPKPSKDQLIQQRSGVIVC 1532
                         .|.||        ||          ||.......|.||..|.:|..:.:.|.
Mouse  1074 VCTSSPDQQIPATTPLPLSTDFPDMEGPGALPLPTQEGRPDCSIPCNPLPSLSQDVQVPAVIPVS 1138

  Fly  1533 Q 1533
            |
Mouse  1139 Q 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	78/173 (45%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	52/152 (34%)
Plekhg2	XP_006539499.1	RhoGEF	103..278	CDD:366202	77/175 (44%)
		PH_PLEKHG1_G2_G3	260..410	CDD:270063	52/151 (34%)
		PTZ00449	<351..742	CDD:185628	88/458 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4732
eggNOG	1	0.900	-	-		E1_KOG3518
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	214	1.000	Inparanoid score	I3617
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43616
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45924
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.950