Protein Alignment GEFmeso and plekhg3

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_012824562.2
• Gene: plekhg3 / 100497371
• XenbaseID: XB-GENE-6468932
• Length: 1472
• Species: Xenopus tropicalis
• Alignment Length: 1290
• Identity: 321/1290 - (24%)
• Similarity: 517/1290 - (40%)
• Gaps: 347/1290 - (26%)

  Fly   447 QLAELEEANKLSAESLDRLTDIKPKFAARLSELARL---NNRPLSSSSICSTSS------SSSSG 502
            ||..|||.:....:...||:........:||..|.:   ::||||..|..||.|      |....
 Frog    51 QLLFLEETSHQGNDESPRLSAASSSSNEKLSISASICSDSDRPLSLFSTESTGSLREGCDSYEDN 115

  Fly   503 SDQLL-------NGKLMATSYLASVESLAESENELGDQHHP------------------------ 536
            ||..|       |.:|:||:..:...:..|.:|.|.:.|.|
 Frog   116 SDVPLGNGTVVHNMELVATAAESLQATYREMQNGLRNNHTPNNNSANRRSHQASRSLSPFGNKVN 180

  Fly   537 ---PAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQ---DWKERACLRVDELQILFANIEEIYEF 595
               ..:|.:|:..|||.|:||.:|:||..:::.||.   |.:|...:..:::..||.|||:|||.
 Frog   181 AITHKLSYVERVVLEINDTERMYVQDLRSIVEDYLGAIIDRQEELPITPEQVCALFGNIEDIYEL 245

  Fly   596 NSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKL 660
            ||.|||.|.|...||..:|.||::....||:||.|||:||.:::.||:.::...........|::
 Frog   246 NSELLQDLDNCRNDPVAVASCFVEKSQDFDIYTQYCTNYPNSVATLTECMRNKTLAKFFREKQEM 310

  Fly   661 LQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVK----EVVEAHV-IMRQVAHNIDQVKRKQEQ 720
            |...|||||||||||||||||||||..:.||.|||    ||:|..: .|..||..|:.:|||.|.
 Frog   311 LNQSLPLGSYLLKPVQRILKYHLLLQEIAKHLDVKVEGYEVLEEAIETMTGVAWYINDMKRKHEH 375

  Fly   721 QSRVKELSGILDGWLGPELTVLGELRQEGLL-MEQHNKQRLVLLFATMLIITKQKEDGRLQFKTY 784
            ..|.:|:..:|..|.|.:||..|||..||.. :::...:|...||...|.|||::.| ...:||:
 Frog   376 AVRQQEIQSLLLNWKGIDLTAYGELVLEGTFRLQRARSERTFFLFDKALFITKRRGD-HYVYKTH 439

  Fly   785 ISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEK--LDIPMRAK 847
            |..::|||.|. ..:...|.|..:...:.|..:.|:..::|.:||.|||.::||.  ..||.:||
 Frog   440 IPCSSLMLIES-ARDSLCFSVTHYKNSKQQHNVQAKTVEEKHVWTHHIKKLILENHHAIIPQKAK 503

  Fly   848 ELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDS 912
            |.:.::.|              ::.|                   |.:.|..::|
 Frog   504 EAILEMDN--------------MYKG-------------------RYKYSPERQK---------- 525

  Fly   913 FNESLEQEEESIS------QAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVKEP 971
              :::...|.|::      |::|||.:.:  .|:|      .|.:::...|..::|....|  :|
 Frog   526 --KTMSAIEPSMTHRSGRRQSEPSKDILK--QLND------KAGLKHAGSDGDLQEFGDIP--QP 578

  Fly   972 C------KCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEEA 1030
            |      ..:|...:.::..|.|    .|.|||           ::.|.|.|         ||:.
 Frog   579 CIGSLGTSLEQPEAEGDKERPVS----TQLSRS-----------SVAELSAS---------DEDE 619

  Fly  1031 EREREQDEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSC---SR 1092
            |..:..|:|:......:|..:.|...||     .|:.|.::.    .|.:|:||....|.   |.
 Frog   620 EEIQLGDDDNDDDDEQTKDPVEEEAPKG-----CKRQNSQSS----GNAEKRRSVEVTSGHQESV 675

  Fly  1093 FYMD--------------LSEFDSSSSTVLKITESTEELRPDG-------------EIELAQEAA 1130
            :.||              :|..:...:.:|:||:.||..:.|.             |.|..:::.
 Frog   676 YKMDKENSEPEEIYKAVVVSSSEDEQAVLLEITDDTEPAKDDSAAHPEVLEPVENEEAESTEDSK 740

  Fly  1131 TLDESTQDQYYSPDHE-TELLSPAEKSKRDAQIVLDLLKNSKEFERIYNKQQKRRESPVSPVSPD 1194
            |. .|.:::..:|.|| |.:|.|:         |||  :.|...||..:...:|.       |..
 Frog   741 TF-SSEEEEEETPTHESTSILPPS---------VLD--QASVIAERFISSMSRRS-------SMA 786

  Fly  1195 ISRGPILP--PPRPPSRSPPPLELEE-------------QEKKPV-------------EEVDSVS 1231
            :..|.::.  .||..||....:.||.             |:...|             .:|:|.|
 Frog   787 LDDGKVIGYITPRLTSRCSSLINLESTDTIIYQNGSSDFQDFSEVCGDTGVDILDTTFSKVNSAS 851

  Fly  1232 EEPIYETLLRNVHVPYKFSPVLGRAKS------SQILKK-RSKTAPAASRPESDYV----TLVYS 1285
            .|.::|...|         |...|..|      .|::.| |:....|.:|..|..:    :|.|.
 Frog   852 MENVFEERER---------PTCKRRDSILSMQDRQLIDKIRTYYDDAENRDASFSIKRRESLNYI 907

  Fly  1286 PEGVLQR------------VGEEVVQRDSCSSSTTSTSSNGSGSTLKRDSQS---------TVIN 1329
            |.|:::.            ..:..:.|...|||:::||...|......|::|         |...
 Frog   908 PTGLVRNSVFKINSLPRFDTTQSSLSRQRMSSSSSNTSGVNSRHASLTDTRSNARESEQLETQTE 972

  Fly  1330 LLMEAA----QEHESRPL-------PKNSV----------SGSESSLLPRALKSIDNLSMAFGRS 1373
            ||:|.|    .:| |.|:       |...:          :..|:|.:..|.|.:...|:....:
 Frog   973 LLLETATNGTSDH-SAPITDEEFRTPDEMIKVWDEFEKVNAWKEASDILEAKKDVKPDSVGESTA 1036

  Fly  1374 NRPPERRV-----------SDVSEMCRQSVLHRQGSEA------VGERMAHVDYADPKALFGLGV 1421
            :...|..:           ||:|.:..:|.|....|.:      |....:..:|..|..|
 Frog  1037 HCALENGLESHEPLLILEDSDLSTITEESPLPTPESTSPKQFGCVPNNTSFSEYKTPVKL----- 1096

  Fly  1422 LNHSERDSVFSLTSSSSDSMCEQQRKRSGVGATFEYEQQVE----------DSLENDFRDSAIYS 1476
              ||:   :..:.|...:.|.|:.:.:....|. :|.|:::          ..:|.|||.:::.:
 Frog  1097 --HSK---IMQMASCMDEDMSEKMKNKVYQLAR-QYSQRIKCNKPVSQRQLKEIEEDFRRNSLPA 1155

  Fly  1477 ------DDNEKRS-----GDYDVHLRRPSSPPPPPPPLGPRPHQPPQIAPKPSKD 1520
                  |..|||.     ..||..:.:...|..|...|. |...|..::..||.|
 Frog  1156 VQEEKLDKKEKRKPILSLPTYDSVILQEHGPTTPTSALS-RDTAPKHLSFSPSCD 1209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	77/171 (45%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	51/150 (34%)
plekhg3	XP_012824562.2	RhoGEF	192..367	CDD:459876	78/174 (45%)
		PH_PLEKHG1_G2_G3	349..493	CDD:270063	49/145 (34%)