DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GEFmeso and plekhg3

DIOPT Version :9

Sequence 1:NP_788403.2 Gene:GEFmeso / 37134 FlyBaseID:FBgn0050115 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_012824562.2 Gene:plekhg3 / 100497371 XenbaseID:XB-GENE-6468932 Length:1472 Species:Xenopus tropicalis


Alignment Length:1290 Identity:321/1290 - (24%)
Similarity:517/1290 - (40%) Gaps:347/1290 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   447 QLAELEEANKLSAESLDRLTDIKPKFAARLSELARL---NNRPLSSSSICSTSS------SSSSG 502
            ||..|||.:....:...||:........:||..|.:   ::||||..|..||.|      |....
 Frog    51 QLLFLEETSHQGNDESPRLSAASSSSNEKLSISASICSDSDRPLSLFSTESTGSLREGCDSYEDN 115

  Fly   503 SDQLL-------NGKLMATSYLASVESLAESENELGDQHHP------------------------ 536
            ||..|       |.:|:||:..:...:..|.:|.|.:.|.|                        
 Frog   116 SDVPLGNGTVVHNMELVATAAESLQATYREMQNGLRNNHTPNNNSANRRSHQASRSLSPFGNKVN 180

  Fly   537 ---PAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQ---DWKERACLRVDELQILFANIEEIYEF 595
               ..:|.:|:..|||.|:||.:|:||..:::.||.   |.:|...:..:::..||.|||:|||.
 Frog   181 AITHKLSYVERVVLEINDTERMYVQDLRSIVEDYLGAIIDRQEELPITPEQVCALFGNIEDIYEL 245

  Fly   596 NSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKL 660
            ||.|||.|.|...||..:|.||::....||:||.|||:||.:::.||:.::...........|::
 Frog   246 NSELLQDLDNCRNDPVAVASCFVEKSQDFDIYTQYCTNYPNSVATLTECMRNKTLAKFFREKQEM 310

  Fly   661 LQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVK----EVVEAHV-IMRQVAHNIDQVKRKQEQ 720
            |...|||||||||||||||||||||..:.||.|||    ||:|..: .|..||..|:.:|||.|.
 Frog   311 LNQSLPLGSYLLKPVQRILKYHLLLQEIAKHLDVKVEGYEVLEEAIETMTGVAWYINDMKRKHEH 375

  Fly   721 QSRVKELSGILDGWLGPELTVLGELRQEGLL-MEQHNKQRLVLLFATMLIITKQKEDGRLQFKTY 784
            ..|.:|:..:|..|.|.:||..|||..||.. :::...:|...||...|.|||::.| ...:||:
 Frog   376 AVRQQEIQSLLLNWKGIDLTAYGELVLEGTFRLQRARSERTFFLFDKALFITKRRGD-HYVYKTH 439

  Fly   785 ISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEK--LDIPMRAK 847
            |..::|||.|. ..:...|.|..:...:.|..:.|:..::|.:||.|||.::||.  ..||.:||
 Frog   440 IPCSSLMLIES-ARDSLCFSVTHYKNSKQQHNVQAKTVEEKHVWTHHIKKLILENHHAIIPQKAK 503

  Fly   848 ELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTVANSSSFDS 912
            |.:.::.|              ::.|                   |.:.|..::|          
 Frog   504 EAILEMDN--------------MYKG-------------------RYKYSPERQK---------- 525

  Fly   913 FNESLEQEEESIS------QAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVKEP 971
              :::...|.|::      |::|||.:.:  .|:|      .|.:::...|..::|....|  :|
 Frog   526 --KTMSAIEPSMTHRSGRRQSEPSKDILK--QLND------KAGLKHAGSDGDLQEFGDIP--QP 578

  Fly   972 C------KCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEEA 1030
            |      ..:|...:.::..|.|    .|.|||           ::.|.|.|         ||:.
 Frog   579 CIGSLGTSLEQPEAEGDKERPVS----TQLSRS-----------SVAELSAS---------DEDE 619

  Fly  1031 EREREQDEDSAASLRGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSC---SR 1092
            |..:..|:|:......:|..:.|...||     .|:.|.::.    .|.:|:||....|.   |.
 Frog   620 EEIQLGDDDNDDDDEQTKDPVEEEAPKG-----CKRQNSQSS----GNAEKRRSVEVTSGHQESV 675

  Fly  1093 FYMD--------------LSEFDSSSSTVLKITESTEELRPDG-------------EIELAQEAA 1130
            :.||              :|..:...:.:|:||:.||..:.|.             |.|..:::.
 Frog   676 YKMDKENSEPEEIYKAVVVSSSEDEQAVLLEITDDTEPAKDDSAAHPEVLEPVENEEAESTEDSK 740

  Fly  1131 TLDESTQDQYYSPDHE-TELLSPAEKSKRDAQIVLDLLKNSKEFERIYNKQQKRRESPVSPVSPD 1194
            |. .|.:::..:|.|| |.:|.|:         |||  :.|...||..:...:|.       |..
 Frog   741 TF-SSEEEEEETPTHESTSILPPS---------VLD--QASVIAERFISSMSRRS-------SMA 786

  Fly  1195 ISRGPILP--PPRPPSRSPPPLELEE-------------QEKKPV-------------EEVDSVS 1231
            :..|.::.  .||..||....:.||.             |:...|             .:|:|.|
 Frog   787 LDDGKVIGYITPRLTSRCSSLINLESTDTIIYQNGSSDFQDFSEVCGDTGVDILDTTFSKVNSAS 851

  Fly  1232 EEPIYETLLRNVHVPYKFSPVLGRAKS------SQILKK-RSKTAPAASRPESDYV----TLVYS 1285
            .|.::|...|         |...|..|      .|::.| |:....|.:|..|..:    :|.|.
 Frog   852 MENVFEERER---------PTCKRRDSILSMQDRQLIDKIRTYYDDAENRDASFSIKRRESLNYI 907

  Fly  1286 PEGVLQR------------VGEEVVQRDSCSSSTTSTSSNGSGSTLKRDSQS---------TVIN 1329
            |.|:::.            ..:..:.|...|||:::||...|......|::|         |...
 Frog   908 PTGLVRNSVFKINSLPRFDTTQSSLSRQRMSSSSSNTSGVNSRHASLTDTRSNARESEQLETQTE 972

  Fly  1330 LLMEAA----QEHESRPL-------PKNSV----------SGSESSLLPRALKSIDNLSMAFGRS 1373
            ||:|.|    .:| |.|:       |...:          :..|:|.:..|.|.:...|:....:
 Frog   973 LLLETATNGTSDH-SAPITDEEFRTPDEMIKVWDEFEKVNAWKEASDILEAKKDVKPDSVGESTA 1036

  Fly  1374 NRPPERRV-----------SDVSEMCRQSVLHRQGSEA------VGERMAHVDYADPKALFGLGV 1421
            :...|..:           ||:|.:..:|.|....|.:      |....:..:|..|..|     
 Frog  1037 HCALENGLESHEPLLILEDSDLSTITEESPLPTPESTSPKQFGCVPNNTSFSEYKTPVKL----- 1096

  Fly  1422 LNHSERDSVFSLTSSSSDSMCEQQRKRSGVGATFEYEQQVE----------DSLENDFRDSAIYS 1476
              ||:   :..:.|...:.|.|:.:.:....|. :|.|:::          ..:|.|||.:::.:
 Frog  1097 --HSK---IMQMASCMDEDMSEKMKNKVYQLAR-QYSQRIKCNKPVSQRQLKEIEEDFRRNSLPA 1155

  Fly  1477 ------DDNEKRS-----GDYDVHLRRPSSPPPPPPPLGPRPHQPPQIAPKPSKD 1520
                  |..|||.     ..||..:.:...|..|...|. |...|..::..||.|
 Frog  1156 VQEEKLDKKEKRKPILSLPTYDSVILQEHGPTTPTSALS-RDTAPKHLSFSPSCD 1209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GEFmesoNP_788403.2 RhoGEF 548..713 CDD:279015 78/172 (45%)
PH_PLEKHG1_G2_G3 694..839 CDD:270063 51/150 (34%)
plekhg3XP_012824562.2 RhoGEF 192..367 CDD:395496 78/174 (45%)
PH_PLEKHG1_G2_G3 349..493 CDD:270063 49/145 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 144 1.000 Domainoid score I4568
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 244 1.000 Inparanoid score I3219
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004049
OrthoInspector 1 1.000 - - otm48780
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3795
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.050

Return to query results.
Submit another query.