DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GEFmeso and plekhg2

DIOPT Version :9

Sequence 1:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_002938639.3	Gene:	plekhg2 / 100492670	XenbaseID:	XB-GENE-6468886	Length:	1982	Species:	Xenopus tropicalis

Alignment Length:	1447	Identity:	334/1447 - (23%)
Similarity:	544/1447 - (37%)	Gaps:	449/1447 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 SAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASV-- 520
            |..||..:.|........::.:...::||:|.||..|::|...|.|....:|.|:::....|.
Frog    60 SVSSLSGIVDGMSGSCTSVNTVCSDSDRPVSLSSSTSSASLQDSHSSFGSSGALVSSQNTGSCYT 124

  Fly   521 -------------ESLAESENELGDQHHP---------------P--AMSVLEKTCLEIVDSERS 555
                         .:|.|.|:|......|               |  .:|.:::..|||:::|::
Frog   125 QQNGSDISLDLTPVALLEGESERRAMDRPFLGYACSPILRKARDPKIKLSHVDRVVLEILETEQA 189

  Fly   556 FVEDLGQVIKGYLQDWKERAC--------LRVDELQILFANIEEIYEFNSMLLQRLINTGRDPGR 612
            :|.||..:::.||      .|        |:.:::..||.|||:||||||.||:.|.|.....|
Frog   190 YVRDLKSIVEDYL------GCIIDCGHLPLKPEQVSTLFCNIEDIYEFNSELLEDLENCNSAHG- 247

  Fly   613 IARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQR 677
            ||.||:...:.||:||.||.:||.::|:|.:.:::..........|.:|.|.|||.:||||||||
Frog   248 IAECFVMRSEDFDIYTLYCMNYPNSVSVLRECMKSEELVQFFRERQAILSHSLPLETYLLKPVQR 312

  Fly   678 ILKYHLLLDSLRKHCDVK----EVVEAHVI-MRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGP 737
            |:||||||..|.||.|..    ||||..:| |..||..|:.:|||||...|::|:...|..|.||
Frog   313 IMKYHLLLQELAKHFDKNAPGYEVVEEAIITMTAVAWYINDMKRKQEHAVRLQEIQSQLVNWQGP 377

  Fly   738 ELTVLGELRQEGLL-MEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPT 801
            :|:..|||..||.. :::..|:|...||:.||:|.|::.| ...:|.:|...||.|:|||. :..
Frog   378 DLSAFGELVLEGTFRVQRMKKERAFFLFSKMLLIAKKRMD-LFIYKMHIFCCNLSLTEHLK-DGL 440

  Fly   802 SFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEK--LDIPMRAKELVYQLGNEEDRTPD-- 862
            ||.|......:||..:.|||:::||.|...||.:::|.  ..||.:||:::  |.|....:||
Frog   441 SFRVSDLTISKHQQVIQARNQEEKRHWVHSIKRLIVENHPASIPQKAKQVL--LENSFQYSPDVR 503

  Fly   863 -----------RSTWKWSLHSGSNSTPTYL--------------------ERRNACRRSE-IRQR 895
                       ...|.:| .|...|.|..|                    :.|...|.|| .::.
Frog   504 LSPEPLKSPRLDELWAFS-RSRRQSEPPQLMCSPERSKKLFSALSLDSGSQHRRGRRLSEPAKEI 567

  Fly   896 NSKFKRK-------------------TVANSSSFDSFNESL-----EQEEESISQAKPSKPLARN 936
            .:.|:..                   ::.:|.|..:...|:     |..||..|.:.|.:.|:.:
Frog   568 QAAFENSDLVPIKHAGSEGELFPSSGSLRSSDSVCTLESSILEVADEVYEEDNSFSLPEEALSGS 632

  Fly   937 NSLDDTALQKLAAAMRYRKR----DAAVKEETKT---------PVK-----EPCKC--------- 974
            .|:.:..|:.|      :||    |..:.|::::         |.:     ||.:.
Frog   633 LSITEEILELL------KKRGLQADLGIMEQSESLALAGSNTEPEEQLQNYEPIEIKTTGTEAEN 691

  Fly   975 DQDAKQDERIEPCSCILRDQR------SRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEEAERE 1033
            |....:...:.|...:|.|..      |:::..|..:.|..:.:|..|...|.....:.||.|||
Frog   692 DLQLMKHANVFPGPEVLCDSMDPLQYPSKASVRQGHINSESSEEEEQKGDLRESPLHMLEELERE 756

  Fly  1034 REQD-------------------------------------EDSAASLRGSK----PDLSER--K 1055
            ...|                                     :|:..|...:|    |:.:|:  |
Frog   757 ETSDLCNTENPEQKEILDKLCLNELENTELSGCIQSENSSVDDTGGSQELAKLELLPEKNEKSLK 821

  Fly  1056 TKG---------------KGFF-------------------------------------EVKQYN 1068
            ||.               |.::                                     |||:..
Frog   822 TKRDSTLTQDDRLLIERIKNYYDTAEAGVSYLSKEDSISYIPTGVVKDSILRFNYILQQEVKKDK 886

  Fly  1069 HKTM--PKKIANLKKQRSSTTKSCSRFYMD------LSEFDS----------------------- 1102
            .|::  ..:.....||.|::.|..||...|      |:|..|
Frog   887 EKSLFGSTEYIGRNKQVSTSRKPWSRLDKDSQVPLPLAEIKSPITLPLEQESEYLSCAEIRKAWK 951

  Fly  1103 -------------------------SSSTVLKITE--------STEELRPDGEIELAQEAATLDE 1134
                                     :|...|.|.|        :::|:.|.|:....|:..:::|
Frog   952 EKEKPNPIESIATPRRGKLCKKRMGASEDALVIMEECDADVPQASKEILPKGDTSKEQKKQSMEE 1016

  Fly  1135 --STQDQYY---------SPDHETELLSPAEKSKRDAQIVLD--LLKNSKEFERIYNKQQ---KR 1183
              :.|:.::         .|....|:..|:..|..:.:   |  ||:||   |:|.||.|   |.
Frog  1017 KITRQENHHKIIIPSMIGDPGESKEICCPSGLSLYETE---DRCLLENS---EKIINKVQLLAKM 1075

  Fly  1184 RESPVSPVSPDISRGPILPPPRPPSRS-----PPPLELEEQEKKPVEEVDSVSEEPIYETLLRNV 1243
            ....:..:......|....|....|::     |..:| |:...|.|.|..|.....|:|||| ::
Frog  1076 YSEKIGRMKTQRRNGDNKRPTVYQSKAIVETLPQVIE-EKAADKSVTEPHSYGHLVIHETLL-HI 1138

  Fly  1244 HVPYKFSPVLGRAK--SSQILKK------RSKTAPAASR------PESDYVTLVYSPEGVLQ--- 1291
            :...:.||:|..|:  :.::.|:      .|.|.|.:|:      |..|.:.:..:.|.|::
Frog  1139 NCIQENSPLLSAAREITGELYKEYLNTVDYSSTQPLSSKETLSEQPLEDKLQIPLTEEPVIEIMT 1203

  Fly  1292 ----RVGEE-------------VVQRDSCSSSTT----STSSNGSGSTLKRDSQSTVINLLMEAA 1335
                ...||             |||   |.:|.:    |.:||..|:.:   :.:..:.|:...|
Frog  1204 KLSLESNEEQEVTIHADENRVAVVQ---CVTSNSVLGPSQTSNDLGTGM---AMTDKLLLVGYTA 1262

  Fly  1336 QEHESRPLPKNSVSGSESSLLPRALKSIDNLSMAFGRSNRPPERRVSDVSEMCRQSVLHRQGSEA 1400
            :|.|.:.|..|....||.:.|.....|:..|..:|.::..|.|......|:         :.:..
Frog  1263 EEKEKQELVANLGEISEKNNLMDFNASVRILQHSFDKNLLPIEPEPHSPSQ---------RKTYT 1318

  Fly  1401 VGERMAHVDYADPKALFGLGVLNHSERDSVFSLTSSSSDSMCEQQRK--RSGVGATFEYEQQVED 1463
            ..|...|:|:            |..|.||    ::.|.....|:|.|  .:|..|...:|...|:
Frog  1319 ENEDKIHMDF------------NELEADS----STESPKMQTEEQPKDFPNGEQAKMNFENMKEE 1367

  Fly  1464 -------SLENDFRDSAIYSDDNEKRSGDYDVHLRRPSSPPPPP------PPL-------GPRPH 1508
                   .:||......|..|.|   |.:..:|.         |      .||       |.:.|
Frog  1368 VTITDQNYIENQKMTEEITQDTN---SSERALHF---------PVMVDTVEPLSAQVFENGSQSH 1420

  Fly  1509 QPPQIAPKPSKDQLIQQ 1525
            ....|.|. ||:.:.:|
Frog  1421 TEDYILPS-SKNIIAKQ 1436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	74/177 (42%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	56/150 (37%)
plekhg2	XP_002938639.3	RhoGEF	179..352	CDD:395496	74/179 (41%)
plekhg2	XP_002938639.3	PH_PLEKHG1_G2_G3	334..478	CDD:270063	56/145 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4568
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3219
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48780
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960