Protein Alignment GEFmeso and arhgef6

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_012825042.2
• Gene: arhgef6 / 100489192
• XenbaseID: XB-GENE-949773
• Length: 777
• Species: Xenopus tropicalis
• Alignment Length: 824
• Identity: 176/824 - (21%)
• Similarity: 317/824 - (38%)
• Gaps: 190/824 - (23%)

  Fly   348 VCSEPLSPVDIVDTINFDLVAQHMERLTLADPGDL------DPRAELIEAVNKTLVN----KP-- 400
            ||:||.|..|.::.|...|.|....|:.|.||.||      ......:.|||:...|    :|
 Frog    56 VCTEPKSEEDCIENIKEFLKACSALRVELFDPVDLYTGENFSKVLSTLSAVNRATENPTSGRPCS 120

  Fly   401 --LVRSSSAACASTICSSPLLTYARTKSLGAKASTL---GGGVPIKLPTAEQLAELEEANKLSAE 460
              |.:|.|....|.|.|..  ||..|:.|..::..|   |.|       :.||.
 Frog   121 GRLSQSHSIPACSQINSQG--TYCSTRVLKRQSKALDMTGNG-------SCQLV----------- 165

  Fly   461 SLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTS----SSSSSGS--DQLLNGKLMATSYLAS 519
                   :|.:|        ..|.:.....|.|...    |....|.  :..||||   :.:..|
 Frog   166 -------VKARF--------NFNQQNEDELSFCKGDTIYVSRVEDGGWWEGTLNGK---SGWFPS 212

  Fly   520 --VESLAESENELGDQHHPPAMSVLEKTCL----------EIVDSERSFVEDLGQVIKGYLQDWK 572
              |:....::..|.    |.|:...|...|          .|:::|||:.::|..::..||:..:
 Frog   213 NYVKEFKSNDKPLS----PKAVKACETAQLTKNYYTVVLQNILETERSYAKELQLLLSTYLRPLQ 273

  Fly   573 ERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDP---GRIARCFIDLRDGF-DVYTTYCTS 633
            ....:...::..|..|.|||..|...|.|.|....:.|   .::..|.::|.:.| .:|.:||::
 Frog   274 SHDKISTVDVSSLLGNFEEICTFQQTLCQALEECAKLPENHQKVGGCLLNLFNQFMSLYLSYCSN 338

  Fly   634 YPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC-----D 693
            :|.|:.:||:  |:....:.:.:....:...|.|.:.|.||..|:.||..||..|.:|.     |
 Frog   339 HPMAVHVLTQ--QSDELGTFMENQGAPVPGILMLTTSLSKPFIRLEKYVTLLQELERHMEEAHPD 401

  Fly   694 VKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQ---- 754
            .|::::|....:.:......::::::.:.::  ||..:.||.|.::..||.......:|.|
 Frog   402 HKDILKATAAFKTLVTQCQDLRKRKQLELQI--LSESIQGWEGEDIKTLGTAVFMSQVMVQCGTN 464

  Fly   755 -HNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLT 818
             ..::|..:||...|::.....    :...:|.|..|.|        |...|:..:|
 Frog   465 EEKEERYFMLFPNALLMLSASP----RMSGFIYQGKLPL--------TGMSVVKLEE-------- 509

  Fly   819 ARNRDQKRIWTQH---IKGVMLEKLDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTY 880
               .|.    |.|   |.|.|:|::        :||.     :.:.|...|...||..:..|.::
 Frog   510 ---NDT----TNHGFEIAGTMIERI--------VVYC-----NNSHDCQEWLEHLHRLTKGTGSH 554

  Fly   881 LERRNACRRSEIRQRNSKFKRKTVANSSSFDSFNESLE----QEEESISQAKPSKPLARNNSLDD 941
               .:.|:...:.. .|..:||.:..|....:....||    .:..::|..:|:.||
 Frog   555 ---ASLCKTQSLTS-TSLTERKQLPPSHYSVTPRGPLEPAKLYKAWTLSCLRPAPPL-------- 607

  Fly   942 TALQKLAAAMRYRKRDAAV-KEETKTP--VK--------EPCKCDQDA---KQDERIEPCSCILR 992
                :.:.|:.|::|.:.: |:.:|:|  ||        |....|:|:   |....:|..:.||:
 Frog   608 ----RPSYALGYKERMSYIFKDSSKSPKNVKKFLPKRKTERKPSDEDSGFRKSTVALEEDAQILK 668

  Fly   993 -----------DQRSRSAKSQSPVFSYKALKERSKSVP--RIGGFSLDEEAEREREQDEDSAASL 1044
                       .|...|...:..|.....|:|.:..:.  |..|.::.||     :...|:..:|
 Frog   669 VIEAYCTGAGFQQSLCSGSRKDSVAQVLLLEEENLIIDELRTNGQTVSEE-----KSLVDTVYAL 728

  Fly  1045 RGSKPDLSERKTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTK 1088
            |....:|.:...:.|...:.:|.:.|.:.|.:..:.||.:.:|:
 Frog   729 RDEVMELKQENKRMKQCLDEEQKSRKELEKIVWKILKQANDSTR 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	43/172 (25%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	28/152 (18%)
arhgef6	XP_012825042.2	CH_alphaPIX	1..117	CDD:409114	19/60 (32%)
		RhoGEF67_u1	115..161	CDD:465201	14/54 (26%)
		SH3_alphaPIX	163..220	CDD:212993	15/85 (18%)
		RhoGEF	243..420	CDD:238091	43/178 (24%)
		PH_Cool_Pix	452..549	CDD:269932	26/136 (19%)
		RhoGEF67_u2	583..681	CDD:465200	21/109 (19%)
		betaPIX_CC	694..774	CDD:465158	17/84 (20%)