Protein Alignment GEFmeso and plekhg1

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: XP_017949742.1
• Gene: plekhg1 / 100488098
• XenbaseID: XB-GENE-6050489
• Length: 1563
• Species: Xenopus tropicalis
• Alignment Length: 1350
• Identity: 328/1350 - (24%)
• Similarity: 512/1350 - (37%)
• Gaps: 357/1350 - (26%)

  Fly   404 SSSAACASTICS-SPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRL-T 466
            ||||:...:.|| ...:|.|....||........|. |||       ||..|.::|.:.|.|: |
 Frog    72 SSSASSRDSHCSFGSRMTLASNSHLGLFHQDKEAGA-IKL-------ELVPARQISNDDLHRICT 128

  Fly   467 DIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMA-TSYLASVESLAESENEL 530
            ..:|..:.|        .:|              |...|....|..| .|...||....|:.:
 Frog   129 KEQPHGSPR--------EKP--------------SDEHQSTQWKAEAKRSIKCSVTEAVETTS-- 169

  Fly   531 GDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQ--DWKERACLRVDELQILFANIEEIY 593
                  |.:..:::...||:.:||::|:||..:::.||.  ..:.|..|..:|...||.||.:||
 Frog   170 ------PKLMYVDRVVQEILHTERAYVQDLKSIVEDYLNCISDQSRLSLGTEERSALFGNICDIY 228

  Fly   594 EFNSMLLQRLINTGRDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQ 658
            .|||.|||.|.|...||..||.||:...:.|.:||.|||:||.::::||:.::...........|
 Frog   229 HFNSELLQELENCDNDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAILTECMRNKILAKFFRERQ 293

  Fly   659 KLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHCDVKE------VVEAHVIMRQVAHNIDQVKRK 717
            ::|||.|||||||||||||||||||||..:..|.| |:      |::|...|::||.:|:.:|||
 Frog   294 EVLQHSLPLGSYLLKPVQRILKYHLLLHEISNHLD-KDTEGYDIVLDAIDTMQRVAWHINDMKRK 357

  Fly   718 QEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNK-QRLVLLFATMLIITKQKEDGRLQF 781
            .|...|::|:..:|..|.||:||..|||..||....|..| :|.:.||..:|:|||:::| ...:
 Frog   358 HEHDIRLQEIQSLLTNWKGPDLTSYGELVLEGTFRFQRAKNERTLFLFDRLLLITKKRDD-TYTY 421

  Fly   782 KTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEK--LDIPM 844
            |.:|...||||.|.:|.||.||.|..:..|:.|..:.|:::..||:|..|:|.::||.  ..||.
 Frog   422 KAHILCCNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWILHLKRLILENHPAKIPA 486

  Fly   845 RAKELVYQ--------------------LGNEED----RTPDRSTWKWSLH-------------- 871
            :||:.:.:                    |..:||    |...:|....:||
 Frog   487 KAKQAILEMDAIHHPGFSYTPEGERKSPLNLKEDLASCRVRRKSEPSSNLHKVMKQDGLSPEMQK 551

  Fly   872 ---------------SGS----------------NSTPTY----------------LERRNACRR 889
                           |||                ||..|.                .|:.:|...
 Frog   552 RSSIQGNLLCQASKLSGSDLLRGSGMRKGGSMNHNSNMTRSQDFYNKEGLSVRLGPAEQSDADDE 616

  Fly   890 SEIRQRNSKFK----RKTVANSSSFD-----SFNESL--------EQEEES-------------- 923
            .|..|.:|:.|    ||.:.:.:|.:     |.|.|:        :.:|||
 Frog   617 EESEQLSSQHKIKGGRKRLNSQASENVEKRRSINLSVCESQISKSQSDEESTKLNTGQIFPSSSG 681

  Fly   924 ----------------------------------ISQAK-PSKPLARNNSLDDTALQKLAAAMRY 953
                                              |.||. ||:...:.|..||...|....:...
 Frog   682 HLPSRQNGAQQSNSLIMNILGGTGALRNIWTDHQIRQALFPSRRSTQENEEDDDDYQMFLLSESA 746

  Fly   954 RKRDAAVKEETKTPVKEPCKCDQDAKQDERIEPCSC-ILR------DQRSRSAKSQSPVFSYKAL 1011
            .:.:::..:|.:.....||.......:::.|...|| |:|      :.:|.||:.:|
 Frog   747 TRLESSWSQEERVASSRPCSWHLGLMEEDTIPNPSCKIVRRASSVGENKSCSARQRS-------- 803

  Fly  1012 KERSKSVPRIGGFSLDEEAEREREQDEDSAASLRGSKPDLS----ERKTKGKGFFEVKQYNHKTM 1072
             ...||.|.       |...|..|:.:.  .:..||..||:    |.......:.::||......
 Frog   804 -HYHKSGPH-------EHFNRSHERHQH--FTCLGSNEDLTIDDIEHVYDNISYEDLKQMGFTRR 858

  Fly  1073 PKKIANLKKQRSSTTKSCSRFYMDLS------EFDSSSSTVLKITESTEELRPDGEIELAQEAAT 1131
            ....|.:.|:...     |:...|:|      :||.:.:::  |....:.|:.......:||...
 Frog   859 HDSDAPINKEGGD-----SQSQEDISIRRLREQFDRTRNSL--ILNKEKNLKKGMSNSNSQELRI 916

  Fly  1132 LDESTQDQYYSPDHETELLSPAEKSKRDAQIVLDL-LKNSKEFERIYNKQQKRRESPVSPVSPDI 1195
            ::|:..|....|:...|.:.....|||...:.|.. .::..:.:|.           ||..|...
 Frog   917 IEENIYDSIQLPEQSLEHVKHKLHSKRSNFLALGTDFQSCDQLDRF-----------VSEDSLQF 970

  Fly  1196 SRGPILPPPRP--------PSRSPPPLELEEQEKKPVEEVDSV----------SEEPIYETLLRN 1242
            |....|....|        .|.....:..:....|..||||.:          :||...|.||.:
 Frog   971 SEDESLDHRVPVKDGDFCYSSSKAGSVSHKSAADKLSEEVDEIWNDLENYIKKNEEKKSERLLAS 1035

  Fly  1243 VHVPYKFSPVLGRAKSSQILKKRSKT-APAASRPESDYVTLVYSPEGV-LQRVGEEVVQRDSCSS 1305
            ..|           ....:|::|..| .|..|:.....::.:..||.: .||.   ::.....|:
 Frog  1036 FPV-----------NKDDVLERRHVTYMPCFSKDMEYSLSSLCLPEDLPSQRT---ILNTSQISN 1086

  Fly  1306 STTSTSSNGSGS--TLKRDSQSTVINLLMEAAQEHESRPLPKNS-VSGSESSLLPRALKSIDNLS 1367
            ..:|..|:.|||  :|||.|..:....|       ||.....|| :..||.:...:.|:|.|...
 Frog  1087 DNSSCGSSNSGSLLSLKRTSIVSETGFL-------ESPLFASNSTIPYSEDTCSSQTLESTDKSK 1144

  Fly  1368 MAFGRSNRPPERRVSDVSEMCRQSVLHRQGSEAVGERMAHVDYADPKALFGLGVLNHSERDSVFS 1432
            .......|...:::...:::.:.....::......::|      .||.|..:
 Frog  1145 SKVFMMARQYSQKIKKANQLLKMKSPEQEQPFYKSQKM------KPKDLAAI------------- 1190

  Fly  1433 LTSSSSDSMCEQQRKRSG--VGATF-EYEQQVEDSLENDFRDSAIYSDDNEKRSGDYDVHLRRPS 1494
                      .:::|:.|  :||.. ||.|..:..:   ||||.|......|:    |.|    .
 Frog  1191 ----------MEEKKQGGCAIGARIAEYSQLYDQII---FRDSPIRMQKEAKK----DSH----K 1234

  Fly  1495 SPPPPPPPLGPRPHQPPQIAPKPSKDQLIQQRSGVIVCQSASRSWVLQQI 1544
            ...|...||.|...||    ..|||   .|||...:    .|.|..||.:
 Frog  1235 VASPSYSPLSPTCQQP----SSPSK---WQQRGKCL----QSNSTGLQSV 1273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	75/171 (44%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	56/151 (37%)
plekhg1	XP_017949742.1	RhoGEF	178..352	CDD:459876	75/174 (43%)
		PH_PLEKHG1_G2_G3	334..479	CDD:270063	55/145 (38%)