Protein Alignment GEFmeso and Tiam2

DIOPT Version :10

• Sequence 1: NP_788403.2
• Gene: GEFmeso / 37134
• FlyBaseID: FBgn0050115
• Length: 1549
• Species: Drosophila melanogaster
• Sequence 2: NP_001414402.1
• Gene: Tiam2 / 100362710
• RGDID: 2324148
• Length: 1714
• Species: Rattus norvegicus
• Alignment Length: 1406
• Identity: 286/1406 - (20%)
• Similarity: 465/1406 - (33%)
• Gaps: 516/1406 - (36%)

  Fly   132 LVQRRSQ---ESQIHGSSSSIASSGSSRRG--SNIRILSPNVHRIITHSDIQPVEAVSAE----- 186
            |.|..||   |:.|....|:.||..:.:.|  ..:|:|......::...|:.......||
  Rat   600 LFQATSQTDLENWITAIHSACASLFAKKHGKEDTVRLLKSQTRGLLQKIDMDSKMKKMAELQLSV 664

  Fly   187 ------------ALKQHQQQSQRSP----TQGRYIKTGHSGTPP------AAGSAP-KLKLSHIP 228
                        .::|.:|..::..    ....|:.:...|..|      ||.|.| ||.|..:
  Rat   665 VSDPKNRKAIENQIRQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAATSRPSKLALGRL- 728

  Fly   229 LSKITGKLSTQSGSELVSTFDSSNEYLNSVAFAAFEKSKP---------QDEDRTPTNKSVPGTP 284
                 |.||..|...||.:.|.|.....:::|....|||.         ....|....|....|.
  Rat   729 -----GVLSVSSFHALVCSRDDSALRKRTLSFTQRAKSKKGLFSSLKGLDTLARKGREKRASITQ 788

  Fly   285 FHFD---GHPFQGRKL--------------------------------TLPRYDSQQSIKLI--- 311
            . ||   .|.:.|.:|                                |...:...:.:.:|
  Rat   789 M-FDSSHSHGYLGTQLPQNSTNSSEVHDLHLYGSSADSTLRDSTWEVQTYVHFQDNEGVTVIIKP 852

  Fly   312 --EMEQLAATSAQLLHAKPATPG--------------TPATPTPSATKAKEFVCSEPLSPVDIVD 360
              .:|.:.|.:.::.|.:|...|              .||.......:..:.:...|||..|:..
  Rat   853 EHRVEDVLALACKMRHLEPTRYGLQLRKVVDESVEWCVPALYEYMQEQVYDEIEVFPLSVYDVQL 917

  Fly   361 TINFDLV------------AQHMERLTLAD-------------------------PGDLD-PRAE 387
            |...|:.            .||:.|:.::|                         ..||| .:.|
  Rat   918 TKTGDMTDFGFAVTAQVDEHQHLSRIFISDVLPDSLAYGGGLRKGNEIRSLNGEAVSDLDLKQME 982

  Fly   388 LI---EAVNKTLVNKPLVRSSSAACASTICSSPLLTYARTKSLGAKASTLGGGVPIKLPTAEQLA 449
            .:   ::|..|||.:|   :.:.|...|.||...|.....|||              ||:..|..
  Rat   983 ALFSEKSVGLTLVARP---ADTRASLCTSCSDSDLFSRDQKSL--------------LPSPNQCQ 1030

  Fly   450 ELEE----ANKLSAESLDRLTDIKPKFAARLSELARLNNRPLSSSSICSTSSSSSSGS-DQLLNG 509
            .|||    ..|.|......:.|:       .:.|.|                |.:.|: ||:.:.
  Rat  1031 LLEEFLDNFKKTSTNDFSNVPDV-------TTGLKR----------------SHTEGTLDQVPHR 1072

  Fly   510 KLMATSYLASVESLAE------SENELGDQHHPPAMSV---------LEKTCLEIVDSERSFVED 559
            :.|..:: .|.|.:.|      |.....|...||...:         |.|...|:||:|:|:|:|
  Rat  1073 EKMEQTF-RSAEQIVELCRGTTSMEAPTDSRDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKD 1136

  Fly   560 LGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRL---INTGRD------PGRIAR 615
            |..:.:.||:..:....|..||::.||.::.|:.||..:.|:.|   |:...|      |.:..:
  Rat  1137 LSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFSVLETPSQFRK 1201

  Fly   616 -------CFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQHRLPLGSYLLK 673
                   .|:...|.|.:|:.:|.::.:...:|.:........:.|.:.....||...|.|||:|
  Rat  1202 LLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDRAFKAFLDARNPTKQHSSTLESYLIK 1266

  Fly   674 PVQRILKYHLLLDSL--------RKHCDVKEVVEAHVIMRQVAHNIDQVKR------------KQ 718
            ||||:|||.|||..|        .:|..:.|.::|   |.:||.:|:::::            ..
  Rat  1267 PVQRVLKYPLLLKELVSLTDHESEEHYHLTEALKA---MEKVASHINEMQKIYEDYGTVFDQLVA 1328

  Fly   719 EQQSRVKELSGILDG---------WLGPELTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQK 774
            ||....||::.:..|         ||.|.|: ||:.|::        .:..|.:|...:|:
  Rat  1329 EQSGTEKEVTELSMGELLMHSTVSWLNPFLS-LGKARKD--------IELTVFVFKRAVIL---- 1380

  Fly   775 EDGRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEK 839
                      :.:.|..|.:.||..         ..|.|.   :|.....|..|.
  Rat  1381 ----------VYKENCKLKKKLPSN---------SRPAHN---SADLDPFKFRWL---------- 1413

  Fly   840 LDIPMRAKELVYQLGNEEDRTPDRSTWKWSLHSGSNSTPTYLERRNACRRSEIRQRNSKFKRKTV 904
              ||:.|  |..:|||... |.:.|||: .:|:                :|||..|     .:|:
  Rat  1414 --IPISA--LQVRLGNTAG-TENNSTWE-LIHT----------------KSEIEGR-----PETI 1451

  Fly   905 ANSSSFDSFNESLEQEEESISQAKPSKPLARNNSLDDTALQKLAAAMRYRKRDAAVKEETKTPVK 969
            ......||        |...|..|..:.:.|.|               :|:.   :|.|  .|::
  Rat  1452 FQLCCSDS--------ESKTSIVKVIRSILREN---------------FRRH---IKCE--LPME 1488

  Fly   970 EPCKCDQDAKQDERIEPCSCILRDQRSRSAKSQSPVFSYKALKERSKSVPRIGGFSLDEEAERER 1034
            :.||        :|:.|            .|::.|| |.|....||..|.|....|       |.
  Rat  1489 KTCK--------DRLVP------------LKNRVPV-SAKLASSRSLKVLRTSSSS-------EW 1525

  Fly  1035 EQDEDSAASLRGSKPDLSE-RKTKGKGFFEVKQYNHKTMPKKIANLKKQRSSTTKSCSRFYMDLS 1098
            ..|.....||...:..||. .::.|....|.:|....|:.:|.|                :..|:
  Rat  1526 PSDPSKGNSLDSDECSLSSGTQSSGCPVAESRQDCKSTVLEKDA----------------HEVLA 1574

  Fly  1099 EFDSSSSTVLKITESTEELRPDGEIELAQEAATLDESTQDQYY-----SPDHETELLSPAEKSKR 1158
            ||                  |||   |.:|:..|.:..:|.::     ||..:.||
  Rat  1575 EF------------------PDG---LIKESDILSDEEEDFHHPLKQGSPTKDIEL--------- 1609

  Fly  1159 DAQIVLDLLKNSKEFERIYNKQQKRRESPVSPVSPDI-SRGPILPPPRPPSRSPPPLELEEQEKK 1222
                         :|:|:...::           ||: |.|     .:||...|
  Rat  1610 -------------QFQRLRISEE-----------PDMHSTG-----QQPPLTGP----------- 1634

  Fly  1223 PVEEVDSVSEEPIYETLLRNVHVPYKFSPVLGRAKSSQ-----ILKKRSKTAPAASRPESDYVTL 1282
                    .|:|   .|:|.     .|.|:..:|.|::     :||.:::.....|.||:..:.|
  Rat  1635 --------GEQP---KLVRG-----HFCPIKRKANSTKRGRGTLLKAQTRHQSLDSHPETASIDL 1683

  Fly  1283 VYSPEGVLQRVGEEVVQRDSCSSSTTS---------TSSNG 1314
                        ..|::|:....|.||         |.|:|
  Rat  1684 ------------NLVLEREFSVQSLTSVVNEECFYETQSHG 1712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GEFmeso	NP_788403.2	RhoGEF	548..712	CDD:459876	54/187 (29%)
		PH_PLEKHG1_G2_G3	694..839	CDD:270063	30/165 (18%)
Tiam2	NP_001414402.1	None