DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgk2 and Rem2

DIOPT Version :9

Sequence 1:	NP_001286577.1	Gene:	Rgk2 / 37132	FlyBaseID:	FBgn0085419	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_073176.2	Gene:	Rem2 / 64626	RGDID:	69081	Length:	341	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	110/470 - (23%)
Similarity:	166/470 - (35%)	Gaps:	174/470 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 HSTLD----------RTCSDSVVSLRYRKSTSDLTQDAEHELSGCKPNKPKAHVEH--------K 363
            |:.||          ..||.   |.|....:...|.:|:..|...||.|..|.::.        .
  Rat     2 HTDLDTDMDADTETVALCSS---SSRQASPSGTPTPEADTTLLKQKPEKLLAELDRGGPPPAPGV 63

  Fly   364 PRRRGSSKGGLAYLASRRSSRESMKSACSNASIVSNDDVGPLAFQSSNRGRQRRTSNFLELPVP- 427
            ||||||                                                      :|||
  Rat    64 PRRRGS------------------------------------------------------MPVPY 74

  Fly   428 DHVRPRVCSLPERPYNPRASDDLYRLRHFSISKGNVVNCGDSIISRRSRSNTSVNSTNSRASERS 492
            .|...|..::.|..:.|:||.                          |.|:.|:.|..
  Rat    75 KHQLRRAQAVDELDWPPQASS--------------------------SGSSDSLGSGE------- 106

  Fly   493 PFEGSCCGAGYANVDSLPATPDDSENLDPPPPARYRVVMLGDAGVGKTALVNQF--MTSEYMH-- 553
                    |..|..|.:                 ::|::||::||||:.|...|  :..:..|
  Rat   107 --------AALAQKDGV-----------------FKVMLLGESGVGKSTLAGTFGGLQGDNAHEM 146

  Fly   554 -----TYDASLVLDDEFGEKTVSVLLDD--EESDM--VFIDHPSVEMSVENSLSTYEPHGCVVVF 609
                 ||:..:::|.|    .|::::.|  |:.|.  ...||         .|.|.:  ..::||
  Rat   147 ENSEDTYERRIMVDKE----EVTLIVYDIWEQGDAGGWLQDH---------CLQTGD--AFLIVF 196

  Fly   610 SVVDRSSFRVAEEIINYLWQENYTKDKAVILVGNKADLARARLITSQEGKALAASRDAKFIETSS 674
            ||.||.||....|.:..|.......|..|||||||:||||:|.::.:||:.||.:...|.||||:
  Rat   197 SVTDRRSFSKVPETLLRLRAGRPHHDLPVILVGNKSDLARSREVSLEEGRHLAGTLSCKHIETSA 261

  Fly   675 GIQHNVDELLVGILKQMRLKEKR--------EKKATASKMKTSRTHISLHLAKELLQKICLSDI- 730
            .:.||..||..|.::|:||:..|        |..:.......:|.......||..|..:...:.
  Rat   262 ALHHNTRELFEGAVRQIRLRRGRGHAGGQRPEPSSPDGPAPPTRRESLTKKAKRFLANLVPRNAK 326

  Fly   731 ---SKSKSCENLHVL 742
               .:|:||.:|.||
  Rat   327 FFKQRSRSCHDLSVL 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk2	NP_001286577.1	RGK	527..742	CDD:206715	72/239 (30%)
Rgk2	NP_001286577.1	small_GTPase	527..694	CDD:197466	61/179 (34%)
Rem2	NP_073176.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72		20/126 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..106		8/47 (17%)
		RGK	116..341	CDD:206715	72/239 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..309		3/26 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8910
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45775
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X743
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880