DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgk2 and GEM

DIOPT Version :9

Sequence 1:	NP_001286577.1	Gene:	Rgk2 / 37132	FlyBaseID:	FBgn0085419	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_005252.1	Gene:	GEM / 2669	HGNCID:	4234	Length:	296	Species:	Homo sapiens

Alignment Length:	275	Identity:	95/275 - (34%)
Similarity:	142/275 - (51%)	Gaps:	53/275 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 YANVDSLPATPDD-------SENLDPPPPAR-----YRVVMLGDAGVGKTALVNQF------MTS 549
            |::.:...|||:|       |::.|....:.     ||||::|:.||||:.|.|.|      |.|
Human    40 YSHRNRHSATPEDHCRRSWSSDSTDSVISSESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSMDS 104

  Fly   550 EY----MHTYDASLVLDDEFGEKTVSVLLD--DEESDMVFI-DHPSVEMSVENSLSTYEPHGCVV 607
            :.    ..||:.:|::|   ||....:|||  :.:.:..:: ||.   |.|.::.        ::
Human   105 DCEVLGEDTYERTLMVD---GESATIILLDMWENKGENEWLHDHC---MQVGDAY--------LI 155

  Fly   608 VFSVVDRSSFRVAEEIINYLWQENYTKDKAVILVGNKADLARARLITSQEGKALAASRDAKFIET 672
            |:|:.||:||..|.|:...|.:...|:|..:||||||:||.|.|.::..||:|.|...|.|||||
Human   156 VYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIET 220

  Fly   673 SSGIQHNVDELLVGILKQMRL----KEKREKKATASKMKTSRTHISLHLAKELLQKICLSDIS-- 731
            |:.:||||.||..||::|:||    |||.|::....|.|.|..    ..|:....||...:..
Human   221 SAAVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQKRKESMP----RKARRFWGKIVAKNNKNM 281

  Fly   732 ----KSKSCENLHVL 742
                |||||.:|.||
Human   282 AFKLKSKSCHDLSVL 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk2	NP_001286577.1	RGK	527..742	CDD:206715	86/237 (36%)
Rgk2	NP_001286577.1	small_GTPase	527..694	CDD:197466	70/183 (38%)
GEM	NP_005252.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..68		7/27 (26%)
		RGK	76..296	CDD:206715	86/237 (36%)
		Calmodulin-binding. /evidence=ECO:0000250	266..285		3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45775
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X743
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880