Protein Alignment Rgk2 and RASD2

DIOPT Version :10

• Sequence 1: NP_001286577.1
• Gene: Rgk2 / 37132
• FlyBaseID: FBgn0085419
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_055125.2
• Gene: RASD2 / 23551
• HGNCID: 18229
• Length: 266
• Species: Homo sapiens
• Alignment Length: 192
• Identity: 49/192 - (25%)
• Similarity: 89/192 - (46%)
• Gaps: 28/192 - (14%)

  Fly   519 LDPPPPARYRVVMLGDAGVGKTALVNQFMTSEYMHTYDASLVLDDEFGEKTVSVLLDDEESDMVF 583
            |..|....||:|:||.:.|||:::|::|:...:...|..::   ::|..|..::     ..||..
Human    12 LSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTI---EDFHRKVYNI-----RGDMYQ 68

  Fly   584 ID-------HPSVEMSVENSLSTYEPHGCVVVFSVVDRSSF----RVAEEIINY-LWQENYTKDK 636
            :|       ||...|   ..||.......::|||:.:|.||    |:.::|:.. ...:|.||:.
Human    69 LDILDTSGNHPFPAM---RRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNKTKEA 130

  Fly   637 A---VILVGNKADLAR-ARLITSQEGKAL-AASRDAKFIETSSGIQHNVDELLVGILKQMRL 693
            |   :::.|||.|... .|.:.:.|.:.| :...:..:.|.|:....||||:...:....:|
Human   131 AELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKL 192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rgk2	NP_001286577.1	RGK	527..742	CDD:206715	47/184 (26%)
RASD2	NP_055125.2	Rhes_like	20..266	CDD:133343	47/184 (26%)
		Effector region	48..56		1/10 (10%)
		Interaction with GNB1, GNB2 and GNB3. /evidence=ECO:0000269|PubMed:19255495	189..235		1/4 (25%)