DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgk2 and Rgk1

DIOPT Version :9

Sequence 1:	NP_001286577.1	Gene:	Rgk2 / 37132	FlyBaseID:	FBgn0085419	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_725875.3	Gene:	Rgk1 / 14462605	FlyBaseID:	FBgn0264753	Length:	1379	Species:	Drosophila melanogaster

Alignment Length:	1012	Identity:	267/1012 - (26%)
Similarity:	385/1012 - (38%)	Gaps:	341/1012 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GHPHSSHHKVPARAASNPLPCKGATPKLPRQYH------------GGPTSSYNYGGYDTPRSPKI 71
            |.|.|:   .|..::....|..|.:|...||..            ..||....:..:|.|:|||.
  Fly   421 GEPSST---TPLLSSQRRHPTGGHSPGSQRQEERRERKEREPSTAPPPTRIREHFTFDPPQSPKS 482

  Fly    72 TTT------------FAQDSCDDV--------------------SSSTPSSYYQTPPSGSIDD-- 102
            ..:            :..:|..|.                    .|....:.......|..:|
  Fly   483 ARSSEKSTSHFSFKNYGNESAKDAGVGSGKGTGSGAGVGGGGGSGSGVGGNGVMAASEGDEEDDE 547

  Fly   103 -SASLLSGRTTARSPKSQ-CQFVFDAVSPSHGRKFEYYEPISPDDGALYYDPPSSPRRQGSKKLM 165
             |...:..|:....|:.: ...:..:|||||.|:                   :||:|:     .
  Fly   548 RSGDSIGNRSKKLRPRERDPNHISPSVSPSHSRR-------------------ASPKRE-----K 588

  Fly   166 RTKTPLDPVPQLT-TTGVDESMAVAMAMGGAGGGGYAQGGPNKRQRDEWELPVISKIEARNLSAA 229
            |..||:.....:: .:....:|..|...|.:|         .::||....:|......:......
  Fly   589 RRTTPIASTGAISKVSSAPPTMKDANFFGSSG---------KQKQRQSQNIPPHQLSPSSQQRKY 644

  Fly   230 AGSSSAGGS----------------------YYGLKR--------------DSCVTDCTQLSMES 258
            :.|||:|.|                      |..::|              ||...:|:....:|
  Fly   645 SSSSSSGSSERCLREATGPGTMFPFDREALDYERIQRECFAPSSTTASNSSDSEAENCSVYERKS 709

  Fly   259 G-------------ETGTQH---------------TNS-----TMVTHTT--------------- 275
            |             |...||               .||     ..|.|||
  Fly   710 GADIFQQYSRLSHQEQLQQHYQEPRDWERDRPPSRKNSKRIRPDSVIHTTIRENQQYVPQSDAFY 774

  Fly   276 ---------TSFSFTE--------PEMEQ------------------------------------ 287
                     :..|:.|        .:.||
  Fly   775 PQAKSSSSPSDHSYAELNKFEDIASKFEQIPPKHGSVSGSGSGSLLNLHHKMPSPGSESAVSPTD 839

  Fly   288 EAGQPQLRRQRRH---------------------AINITSNP-----------GYQVLHSSHSTL 320
            .|.:...:.::||                     .||:|:||           ...|:.....:|
  Fly   840 SARRRSFKNKQRHQKEEHFYIQTEDRSGTAAGNGPINVTANPLEAAAVCKQPRATIVVQQPSLSL 904

  Fly   321 DRTCSDSVVSLRYRKSTSDLTQDAEHELSGCKPNK-----PKAHVEHKPRRRGSSKGGLAYLASR 380
            |.|    |.:|..:.....::.:...||...|.|.     |.||:.|..:....:...|.....:
  Fly   905 DNT----VETLLIKNEGDFISVEQGKELVARKRNSQQLAHPPAHLHHHTQNHAHNHHTLQQQQHQ 965

  Fly   381 RSSR------ESMKSACSNASIVSNDDVG--PLAFQSSNRGRQR-------RTS---NFLELPVP 427
            :..:      |:|:......:.::.:::.  .:.:.|.:..|.:       |.|   |.|.||
  Fly   966 QQQQQQHKRDENMRQLLDVTNTLTIEELRDFQMRYGSPHHSRSQSVKMPGSRASGRPNQLCLP-- 1028

  Fly   428 DHVRPRVCSLPERPYNPRASDDLYRLRHFSISKGNVVNCGDSIISRRSRSNTSVNSTNSRASERS 492
             ..|.||.|:|    |....::.||||||||:...|||.|||:.|||||||.||.|:||.....:
  Fly  1029 -QQRSRVASMP----NTGVEEEYYRLRHFSITGKGVVNRGDSLKSRRSRSNNSVASSNSSTEHLT 1088

  Fly   493 PFEGSCCGAGYANVDSLPATPDDSENLDPPPPARYRVVMLGDAGVGKTALVNQFMTSEYMHTYDA 557
            ..:.....|..:...||.::.:.|.:  .|....|||:|||...|||::||:|||||||:|.||.
  Fly  1089 TQQQLSAPASVSARTSLASSRESSTS--NPGNGPYRVLMLGGPAVGKSSLVSQFMTSEYLHAYDT 1151

  Fly   558 SLVLDDEFGEKTVSVLLDDEESDMVFIDHPSVEMSVENSLSTYEPHGCVVVFSVVDRSSFRVAEE 622
            |  :|||.|||.|||||..|||:::||||...||:.:..|:.|:|||..|::|..|||||.|||:
  Fly  1152 S--IDDESGEKAVSVLLSGEESELIFIDHGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSVAEQ 1214

  Fly   623 IINYLWQENYTKDKAVILVGNKADLARARLITSQEGKALAASRDAKFIETSSGIQHNVDELLVGI 687
            ::..||.......||||||.|||||||:||:||:||||:|.:.|.||||||.||.|||||||||:
  Fly  1215 VLQVLWTNQNIAQKAVILVSNKADLARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELLVGL 1279

  Fly   688 LKQMRLK-EKREK----------------------------------------------KATASK 705
            |.|:||| |..||                                              :::..|
  Fly  1280 LSQIRLKLENPEKSRDLFRKRSIRKSKRRACSPLNAGCLNANTPLGPLGEAVATPPGSAQSSPRK 1344

  Fly   706 MKTSRTHISLHLAKELLQKICLSDISKSKSCENLHVL 742
            .:.|||..||.: |.||.::...| ||||||||||||
  Fly  1345 YRGSRTSTSLKV-KGLLGRVWTRD-SKSKSCENLHVL 1379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk2	NP_001286577.1	RGK	527..742	CDD:206715	127/261 (49%)
Rgk2	NP_001286577.1	small_GTPase	527..694	CDD:197466	102/166 (61%)
Rgk1	NP_725875.3	DUF2967	459..715	CDD:288079	46/288 (16%)
		P-loop_NTPase	1121..1379	CDD:304359	127/261 (49%)
		small_GTPase	1121..1286	CDD:197466	102/166 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I4492
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8675
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45775
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5084
SonicParanoid	1	1.000	-	-		X743
	7	7.050