DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pepck1 and Pck2

DIOPT Version :9

Sequence 1:	NP_523784.2	Gene:	Pepck1 / 37131	FlyBaseID:	FBgn0003067	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_083270.2	Gene:	Pck2 / 74551	MGIID:	1860456	Length:	640	Species:	Mus musculus

Alignment Length:	616	Identity:	387/616 - (62%)
Similarity:	472/616 - (76%)	Gaps:	5/616 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IRGIPISYGNVDLLTTGVRAFVEEGIALCQPDQVHICDGSEQENKVLIKSLLEAGTIVPLPKYDN 99
            |:.:.:..|::..|..|||.||.....||||:.:|||||:|.||..::..|.|.|.|..||||.|
Mouse    27 IQTLHVLSGDMSQLPAGVRDFVARSAHLCQPEGIHICDGTEAENTAILALLEEQGLIRKLPKYKN 91

  Fly   100 CWLARTNPADVARVESRTFICTERREETIPTPVEGVKGTLGNWISPSDMDAAVQQRFPGCMKGRT 164
            ||||||:|.|||||||:|.|.|..:.:|:|....|.:|.||||:||.:...||.:||||||:||.
Mouse    92 CWLARTDPKDVARVESKTVIVTPSQRDTVPLLAGGARGQLGNWMSPDEFQRAVDERFPGCMQGRI 156

  Fly   165 MYVVPFSMGPVGSPLSKIGIELTDSAYVVASMRIMTRMGAAVLRQLAKKEEFVRALHSVGAPANG 229
            |||:||||||||||||:||::||||||||||||||||:|..||:.|. ..:|::.|||||.|..|
Mouse   157 MYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALG-DGDFIKCLHSVGQPLTG 220

  Fly   230 QVEQ-PSWPCDPERTIILHKPAENLIVSYGSGYGGNSLLGKKCFALRIGSTIAKQEGWLAEHMLI 293
            ..:. ..|||:||:|:|.|.|.:..|||:|||||||||||||||||||.|.:|:.||||||||||
Mouse   221 HGDPVGQWPCNPEKTLIGHVPDQREIVSFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLI 285

  Fly   294 LGITDPKGEKKYITAAFPSACGKTNLAMLNPSLANYKVECVGDDIAWMKFDSQGVLRAINPENGF 358
            ||||:|.|:|:|:.||||||||||||||:.|:|..:||||||||||||:|||:|.||||||||||
Mouse   286 LGITNPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGQLRAINPENGF 350

  Fly   359 FGVAPGTSMETNPIAMNTVFKNTIFTNVASTSDGGVFWEGMESSLAPNVQITDWLGKPWTKDSGK 423
            ||||||||..|||.||.|:..||:|||||.||||||:|||::..|.|.|.||.||||||.....:
Mouse   351 FGVAPGTSAATNPNAMATIQSNTLFTNVAETSDGGVYWEGIDQPLPPGVTITSWLGKPWKPGDKE 415

  Fly   424 PAAHPNSRFCTPAAQCPIIDEAWEDPAGVPISAMLFGGRRPAGVPLIYEARDWTHGVFIGAAMRS 488
            |.||||||||.||.||||:|.|||.|.||||.|::||||||.||||:|||.:|.||||:|:||||
Mouse   416 PCAHPNSRFCVPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRS 480

  Fly   489 EATAAAEHKGKVIMHDPFAMRPFFGYNFGDYVAHWLSME--KRGQVPKIFHVNWFRKSAEGKFMW 551
            |:|||||||||.|||||||||||||||||.|:.||||||  |..::|:||||||||:...|:|:|
Mouse   481 ESTAAAEHKGKTIMHDPFAMRPFFGYNFGRYLEHWLSMEGQKGARLPRIFHVNWFRRDEAGRFLW 545

  Fly   552 PGYGENSRVLEWILRRVNGESCYVDSAIGHIPAEGALNLDGMKDKVDVKEIFSLPKEFWSQEVKD 616
            ||:|||:|||:||.||:.||....::.||.:|.||||:|.|: ..||..::||:||:||.|||:|
Mouse   546 PGFGENARVLDWICRRLEGEDSAQETPIGLVPKEGALDLSGL-SAVDTSQLFSIPKDFWEQEVRD 609

  Fly   617 IRTYFESQVGADLPASIYQQLDELSSRVDNL 647
            ||.|...||..|||..:..:|:.|..||..:
Mouse   610 IRGYLTEQVNQDLPKEVLAELEALEGRVQKM 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck1	NP_523784.2	PEPCK	54..644	CDD:279197	379/592 (64%)
Pck2	NP_083270.2	PEPCK_GTP	44..633	CDD:238417	380/590 (64%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P07379	253..255		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P07379	421..423		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850122
Domainoid	1	1.000	549	1.000	Domainoid score	I256
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3356
Inparanoid	1	1.050	839	1.000	Inparanoid score	I445
Isobase	1	0.950	-	0	Normalized mean entropy	S2278
OMA	1	1.010	-	-		QHG61114
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm8845
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	LDO	PTHR11561
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.710