Protein Alignment Pepck1 and PCK2

DIOPT Version :9

• Sequence 1: NP_523784.2
• Gene: Pepck1 / 37131
• FlyBaseID: FBgn0003067
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_004554.3
• Gene: PCK2 / 5106
• HGNCID: 8725
• Length: 640
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 394/616 - (63%)
• Similarity: 480/616 - (77%)
• Gaps: 5/616 - (0%)

  Fly    35 IRGIPISYGNVDLLTTGVRAFVEEGIALCQPDQVHICDGSEQENKVLIKSLLEAGTIVPLPKYDN 99
            |:.:.:..|::..|.||:|.|||....||||:.:|||||:|.||...:..|.:.|.|..||||:|
Human    27 IQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGIHICDGTEAENTATLTLLEQQGLIRKLPKYNN 91

  Fly   100 CWLARTNPADVARVESRTFICTERREETIPTPVEGVKGTLGNWISPSDMDAAVQQRFPGCMKGRT 164
            ||||||:|.|||||||:|.|.|..:.:|:|.|..|.:|.||||:||:|...||.:||||||:|||
Human    92 CWLARTDPKDVARVESKTVIVTPSQRDTVPLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRT 156

  Fly   165 MYVVPFSMGPVGSPLSKIGIELTDSAYVVASMRIMTRMGAAVLRQLAKKEEFVRALHSVGAPANG 229
            |||:||||||||||||:||::||||||||||||||||:|..||:.|. ..:||:.|||||.|..|
Human   157 MYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALG-DGDFVKCLHSVGQPLTG 220

  Fly   230 QVEQPS-WPCDPERTIILHKPAENLIVSYGSGYGGNSLLGKKCFALRIGSTIAKQEGWLAEHMLI 293
            |.|..| |||:||:|:|.|.|.:..|:|:|||||||||||||||||||.|.:|:.||||||||||
Human   221 QGEPVSQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLI 285

  Fly   294 LGITDPKGEKKYITAAFPSACGKTNLAMLNPSLANYKVECVGDDIAWMKFDSQGVLRAINPENGF 358
            ||||.|.|:|:|:.||||||||||||||:.|:|..:||||||||||||:|||:|.||||||||||
Human   286 LGITSPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGF 350

  Fly   359 FGVAPGTSMETNPIAMNTVFKNTIFTNVASTSDGGVFWEGMESSLAPNVQITDWLGKPWTKDSGK 423
            ||||||||..|||.||.|:..||||||||.||||||:|||::..|.|.|.:|.||||||.....:
Human   351 FGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKE 415

  Fly   424 PAAHPNSRFCTPAAQCPIIDEAWEDPAGVPISAMLFGGRRPAGVPLIYEARDWTHGVFIGAAMRS 488
            |.||||||||.||.||||:|.|||.|.||||.|::||||||.||||:|||.:|.||||:|:||||
Human   416 PCAHPNSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRS 480

  Fly   489 EATAAAEHKGKVIMHDPFAMRPFFGYNFGDYVAHWLSME--KRGQVPKIFHVNWFRKSAEGKFMW 551
            |:|||||||||:|||||||||||||||||.|:.||||||  |..|:|:||||||||:...|.|:|
Human   481 ESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEAGHFLW 545

  Fly   552 PGYGENSRVLEWILRRVNGESCYVDSAIGHIPAEGALNLDGMKDKVDVKEIFSLPKEFWSQEVKD 616
            ||:|||:|||:||.||:.||....::.||.:|.||||:|.|:: .:|..::|||||:||.|||:|
Human   546 PGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLR-AIDTTQLFSLPKDFWEQEVRD 609

  Fly   617 IRTYFESQVGADLPASIYQQLDELSSRVDNL 647
            ||:|...||..|||..:..:|:.|..||..:
Human   610 IRSYLTEQVNQDLPKEVLAELEALERRVHKM 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pepck1	NP_523784.2	PEPCK	54..644	CDD:279197	386/592 (65%)
PCK2	NP_004554.3	PEPCK_GTP	44..633	CDD:238417	386/590 (65%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P07379	253..255		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P07379	421..423		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159755
Domainoid	1	1.000	544	1.000	Domainoid score	I259
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3356
Inparanoid	1	1.050	841	1.000	Inparanoid score	I448
Isobase	1	0.950	-	0	Normalized mean entropy	S2278
OMA	1	1.010	-	-		QHG61114
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm8610
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	LDO	PTHR11561
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.710