Protein Alignment Pepck1 and PCK1

DIOPT Version :9

• Sequence 1: NP_523784.2
• Gene: Pepck1 / 37131
• FlyBaseID: FBgn0003067
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_002582.3
• Gene: PCK1 / 5105
• HGNCID: 8724
• Length: 622
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 396/610 - (64%)
• Similarity: 477/610 - (78%)
• Gaps: 10/610 - (1%)

  Fly    43 GNVDLLTTGVRAFVEEGIALCQPDQVHICDGSEQENKVLIKSLLEAGTIVPLPKYDNCWLARTNP 107
            |::|.|...||.|:|....|||||.:|||||||:||..|:..:.|.|.:..|.||||||||.|:|
Human    18 GSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDP 82

  Fly   108 ADVARVESRTFICTERREETIPTPVEGVKGTLGNWISPSDMDAAVQQRFPGCMKGRTMYVVPFSM 172
            .||||:||:|.|.|:.:.:|:|.|..|: ..||.|:|..|.:.|...|||||||||||||:||||
Human    83 RDVARIESKTVIVTQEQRDTVPIPKTGL-SQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSM 146

  Fly   173 GPVGSPLSKIGIELTDSAYVVASMRIMTRMGAAVLRQLAKKEEFVRALHSVGAPANGQVEQP--- 234
            ||:||||||||||||||.|||||||||||||..||..:. ..|||:.|||||.|.  .:::|
Human   147 GPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEAVG-DGEFVKCLHSVGCPL--PLQKPLVN 208

  Fly   235 SWPCDPERTIILHKPAENLIVSYGSGYGGNSLLGKKCFALRIGSTIAKQEGWLAEHMLILGITDP 299
            :|||:||.|:|.|.|....|:|:||||||||||||||||||:.|.:||:||||||||||||||:|
Human   209 NWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLILGITNP 273

  Fly   300 KGEKKYITAAFPSACGKTNLAMLNPSLANYKVECVGDDIAWMKFDSQGVLRAINPENGFFGVAPG 364
            :|||||:.||||||||||||||:||||..:|||||||||||||||:||.||||||||||||||||
Human   274 EGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPG 338

  Fly   365 TSMETNPIAMNTVFKNTIFTNVASTSDGGVFWEGMESSLAPNVQITDWLGKPWTKDSGKPAAHPN 429
            ||::|||.|:.|:.|||||||||.||||||:|||::..||..|.||.|..|.|:.:.|:|.||||
Human   339 TSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPN 403

  Fly   430 SRFCTPAAQCPIIDEAWEDPAGVPISAMLFGGRRPAGVPLIYEARDWTHGVFIGAAMRSEATAAA 494
            |||||||:||||||.|||.|.||||..::|||||||||||:|||..|.||||:||||||||||||
Human   404 SRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAA 468

  Fly   495 EHKGKVIMHDPFAMRPFFGYNFGDYVAHWLSMEKR--GQVPKIFHVNWFRKSAEGKFMWPGYGEN 557
            |||||:|||||||||||||||||.|:||||||.:.  .::|||||||||||..||||:|||:|||
Human   469 EHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGEN 533

  Fly   558 SRVLEWILRRVNGESCYVDSAIGHIPAEGALNLDGMKDKVDVKEIFSLPKEFWSQEVKDIRTYFE 622
            ||||||:..|::|::....:.||:||.|.||||.|: ..:::.|:||:.||||.:||:||..|.|
Human   534 SRVLEWMFNRIDGKASTKLTPIGYIPKEDALNLKGL-GHINMMELFSISKEFWEKEVEDIEKYLE 597

  Fly   623 SQVGADLPASIYQQLDELSSRVDNL 647
            .||.||||..|.:::..|..|:..:
Human   598 DQVNADLPCEIEREILALKQRISQM 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pepck1	NP_523784.2	PEPCK	54..644	CDD:279197	390/594 (66%)
PCK1	NP_002582.3	PEPCK_GTP	27..615	CDD:238417	391/592 (66%)
		Substrate binding. /evidence=ECO:0000269|PubMed:11851336, ECO:0000269|PubMed:14552798, ECO:0000269|PubMed:17532214	235..237		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269|PubMed:11851336, ECO:0000269|PubMed:14552798, ECO:0000269|PubMed:17532214	403..405		1/1 (100%)
		Omega-loop. /evidence=ECO:0000250|UniProtKB:P07379	457..487		28/29 (97%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159753
Domainoid	1	1.000	544	1.000	Domainoid score	I259
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	841	1.000	Inparanoid score	I448
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61114
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm8610
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	O	PTHR11561
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9320
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790