DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pepck1 and pck2

DIOPT Version :9

Sequence 1:	NP_523784.2	Gene:	Pepck1 / 37131	FlyBaseID:	FBgn0003067	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_998357.1	Gene:	pck2 / 406473	ZFINID:	ZDB-GENE-040426-2266	Length:	636	Species:	Danio rerio

Alignment Length:	614	Identity:	378/614 - (61%)
Similarity:	456/614 - (74%)	Gaps:	13/614 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SYGNVDLLTTGVRAFVEEGIALCQPDQVHICDGSEQENKVLIKSLLEAGTIVPLPKYDNCWLART 105
            |..::..|...|..||....|.|:|.:||:..|:.:|...|:.:|.:.|.:..|.||:|||||||
Zfish    24 SLASIPSLPPSVAEFVSGAAAECKPAKVHVVTGTPEETADLLANLEKEGMVKKLAKYENCWLART 88

  Fly   106 NPADVARVESRTFICTERREETIPTPVEGVKGTLGNWISPSDMDAAVQQRFPGCMKGRTMYVVPF 170
            :|.|||||||:|.|.|:.:.:|||.|..|.|..||:|:|..|...|.:.||||||.||||||:||
Zfish    89 DPKDVARVESKTVIVTKNQRDTIPIPSGGAKSQLGSWMSEQDFQKAREDRFPGCMAGRTMYVIPF 153

  Fly   171 SMGPVGSPLSKIGIELTDSAYVVASMRIMTRMGAAVLRQLAKKEEFVRALHSVGAPANGQVEQP- 234
            |||||.|.|:|.|:::|||.||||||.||||||..|:.:||:..||||..||||.|.  .::.|
Zfish   154 SMGPVNSSLAKFGVQVTDSPYVVASMGIMTRMGTPVMEKLAQGAEFVRCQHSVGRPL--PLKGPL 216

  Fly   235 --SWPCDPERTIILHKPAENLIVSYGSGYGGNSLLGKKCFALRIGSTIAKQEGWLAEHMLILGIT 297
              ||||:||:.:|.|.|....|:|:|||||||||||||||||||.|.|||.||||||||||||||
Zfish   217 VNSWPCNPEKVLISHLPDTRQILSFGSGYGGNSLLGKKCFALRIASRIAKDEGWLAEHMLILGIT 281

  Fly   298 DPKGEKKYITAAFPSACGKTNLAMLNPSLANYKVECVGDDIAWMKFDSQGVLRAINPENGFFGVA 362
            :|:|.|:||.||||||||||||||:.|||..:||||||||||||||||||.||||||||||||||
Zfish   282 NPQGVKRYIAAAFPSACGKTNLAMMKPSLPGWKVECVGDDIAWMKFDSQGKLRAINPENGFFGVA 346

  Fly   363 PGTSMETNPIAMNTVFKNTIFTNVASTSDGGVFWEGMESSLAPNVQITDWLGKPWTKDSGKPAAH 427
            ||||::|||.||.|:.:||:||||..||||||:|||:|.. ||.:::|||.||.|........||
Zfish   347 PGTSLKTNPHAMETISRNTVFTNVGETSDGGVWWEGLEPP-APGIKLTDWHGKSWKYGDSTLCAH 410

  Fly   428 PNSRFCTPAAQCPIIDEAWEDPAGVPISAMLFGGRRPAGVPLIYEARDWTHGVFIGAAMRSEATA 492
            ||||||.||.||||||..||...||||.|::||||||.||||:||:.:|.||||:|||||||:||
Zfish   411 PNSRFCAPAGQCPIIDPLWESDEGVPIDAIVFGGRRPEGVPLVYESFNWRHGVFVGAAMRSESTA 475

  Fly   493 AAEHKGKVIMHDPFAMRPFFGYNFGDYVAHWLSMEKR---GQVPKIFHVNWFRKSAE-GKFMWPG 553
            |||||||||||||||||||||||||||::||||||.|   .|:|||||||||||..: |.|:|||
Zfish   476 AAEHKGKVIMHDPFAMRPFFGYNFGDYLSHWLSMETRKGPTQLPKIFHVNWFRKDQKTGSFLWPG 540

  Fly   554 YGENSRVLEWILRRVNGES---CYVDSAIGHIPAEGALNLDGMKDKVDVKEIFSLPKEFWSQEVK 615
            :|||:||||||.:|....|   ....|.:|.||..||:|.:|:...:|:..:|.|||.||.:|.:
Zfish   541 FGENARVLEWIFKRCGRTSENEAATKSIVGWIPQNGAINTEGLGGNIDMGALFDLPKPFWQKETQ 605

  Fly   616 DIRTYFESQVGADLPASIYQQLDELSSRV 644
            ::||||..||||||||.:..:|..|..||
Zfish   606 ELRTYFNQQVGADLPAQVEGELKALEERV 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck1	NP_523784.2	PEPCK	54..644	CDD:279197	373/599 (62%)
pck2	NP_998357.1	PEPCK	37..634	CDD:279197	373/599 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595986
Domainoid	1	1.000	294	1.000	Domainoid score	I1470
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3356
Inparanoid	1	1.050	831	1.000	Inparanoid score	I438
OMA	1	1.010	-	-		QHG61114
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm6511
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	LDO	PTHR11561
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760