DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pepck1 and pck1

DIOPT Version :9

Sequence 1:	NP_523784.2	Gene:	Pepck1 / 37131	FlyBaseID:	FBgn0003067	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_999916.1	Gene:	pck1 / 378727	ZFINID:	ZDB-GENE-030909-11	Length:	630	Species:	Danio rerio

Alignment Length:	620	Identity:	398/620 - (64%)
Similarity:	480/620 - (77%)	Gaps:	10/620 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LYSHIRGIP-ISYGNVDLLTTGVRAFVEEGIALCQPDQVHICDGSEQENKVLIKSLLEAGTIVPL 94
            |.|..|..| :..|::..|:..||.|::..::|||||.:||||||||||..::..|.|.|.|..|
Zfish     5 LQSQDRSCPRVLQGDLASLSASVREFIDSSVSLCQPDALHICDGSEQENSTILSLLEEQGAIKRL 69

  Fly    95 PKYDNCWLARTNPADVARVESRTFICTERREETIPTPVEGVKGTLGNWISPSDMDAAVQQRFPGC 159
            .||.|||||||:|.|||||||:|.|.|..:.:|:|||..|....||.|:.|.:.|.|:..|||||
Zfish    70 RKYSNCWLARTDPRDVARVESKTVIVTAEQRDTVPTPTGGGVSQLGRWMCPEEWDKAMNLRFPGC 134

  Fly   160 MKGRTMYVVPFSMGPVGSPLSKIGIELTDSAYVVASMRIMTRMGAAVLRQLAKKEEFVRALHSVG 224
            ||||.|||:|||||||||||||||:|||||.|||||||||||||..||..|. ..||||.|||||
Zfish   135 MKGRVMYVIPFSMGPVGSPLSKIGVELTDSPYVVASMRIMTRMGKTVLSALG-NGEFVRCLHSVG 198

  Fly   225 APANGQVEQP---SWPCDPERTIILHKPAENLIVSYGSGYGGNSLLGKKCFALRIGSTIAKQEGW 286
            .|.  .:::|   :|||:||.|::.|.|.:..|||:|||||||||||||||||||.|.|||:|||
Zfish   199 CPL--PLKKPLVNNWPCNPELTLVAHIPDQRKIVSFGSGYGGNSLLGKKCFALRIASRIAKEEGW 261

  Fly   287 LAEHMLILGITDPKGEKKYITAAFPSACGKTNLAMLNPSLANYKVECVGDDIAWMKFDSQGVLRA 351
            |||||||||||:|.|:|||..|||||||||||||||.|||..:|||||||||||||||.:|.|||
Zfish   262 LAEHMLILGITNPAGQKKYFAAAFPSACGKTNLAMLKPSLPGWKVECVGDDIAWMKFDKEGNLRA 326

  Fly   352 INPENGFFGVAPGTSMETNPIAMNTVFKNTIFTNVASTSDGGVFWEGMESSLAPNVQITDWLGKP 416
            |||||||||||||||.:|||.||:|:..||:|||||.:||||||||||:..|...|.:|.|..:|
Zfish   327 INPENGFFGVAPGTSSKTNPNAMSTISCNTLFTNVAESSDGGVFWEGMDEDLPEGVTLTSWKNQP 391

  Fly   417 WTKDSGKPAAHPNSRFCTPAAQCPIIDEAWEDPAGVPISAMLFGGRRPAGVPLIYEARDWTHGVF 481
            ||.:.|:|.||||||||||||||||||..||.|.||||.|::||||||.||||:|||.||.||||
Zfish   392 WTPEDGEPCAHPNSRFCTPAAQCPIIDPQWESPEGVPIEAIIFGGRRPQGVPLVYEAFDWAHGVF 456

  Fly   482 IGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGDYVAHWLSMEKR--GQVPKIFHVNWFRKS 544
            :||:||||||||||||||||||||||||||||||||.|::||||||:|  .::|||||||||.:|
Zfish   457 VGASMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGQYLSHWLSMEQRPGAKLPKIFHVNWFGRS 521

  Fly   545 AEGKFMWPGYGENSRVLEWILRRVNGESCYVDSAIGHIPAEGALNLDGMKDKVDVKEIFSLPKEF 609
            :.|:|:|||:|||.|||||:..|::|.:....:|:|.:||:|||||.|:.| |:..|:|.:.:||
Zfish   522 SSGRFLWPGFGENIRVLEWMFGRLSGGAEARTTAVGLVPADGALNLHGLPD-VEPLELFRVSQEF 585

  Fly   610 WSQEVKDIRTYFESQVGADLPASIYQQLDELSSRV 644
            |.||:::||.||..::..|||..:.:||:.|..|:
Zfish   586 WMQELQEIREYFSRELNRDLPQEMQRQLELLEHRL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck1	NP_523784.2	PEPCK	54..644	CDD:279197	389/594 (65%)
pck1	NP_999916.1	PEPCK_GTP	27..616	CDD:238417	390/592 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595984
Domainoid	1	1.000	527	1.000	Domainoid score	I275
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	831	1.000	Inparanoid score	I438
OMA	1	1.010	-	-		QHG61114
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm6511
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	O	PTHR11561
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9320
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790