DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pepck1 and Pck1

DIOPT Version :9

Sequence 1:	NP_523784.2	Gene:	Pepck1 / 37131	FlyBaseID:	FBgn0003067	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_942075.1	Gene:	Pck1 / 362282	RGDID:	3267	Length:	622	Species:	Rattus norvegicus

Alignment Length:	638	Identity:	402/638 - (63%)
Similarity:	479/638 - (75%)	Gaps:	27/638 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PQLHKLRQDNCGLYSHIRGIPIS----YGNVDLLTTGVRAFVEEGIALCQPDQVHICDGSEQENK 79
            ||||             .|:..|    .|::|.|...||.|||....||||:.:|||||||:|..
  Rat     3 PQLH-------------NGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYG 54

  Fly    80 VLIKSLLEAGTIVPLPKYDNCWLARTNPADVARVESRTFICTERREETIPTPVEGVKGTLGNWIS 144
            .|:..:.|.|.|..|.||||||||.|:|.||||:||:|.|.|:.:.:|:|.|..| :..||.|:|
  Rat    55 RLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSG-QSQLGRWMS 118

  Fly   145 PSDMDAAVQQRFPGCMKGRTMYVVPFSMGPVGSPLSKIGIELTDSAYVVASMRIMTRMGAAVLRQ 209
            ..|.:.|...|||||||||||||:||||||:||||:|||||||||.|||||||||||||.:||..
  Rat   119 EEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEA 183

  Fly   210 LAKKEEFVRALHSVGAPANGQVEQP---SWPCDPERTIILHKPAENLIVSYGSGYGGNSLLGKKC 271
            |. ..||::.|||||.|.  .:::|   :|.|:||.|:|.|.|....|:|:||||||||||||||
  Rat   184 LG-DGEFIKCLHSVGCPL--PLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKC 245

  Fly   272 FALRIGSTIAKQEGWLAEHMLILGITDPKGEKKYITAAFPSACGKTNLAMLNPSLANYKVECVGD 336
            |||||.|.:||:||||||||||||||:|:|:|||:.||||||||||||||:||:|..:|||||||
  Rat   246 FALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGD 310

  Fly   337 DIAWMKFDSQGVLRAINPENGFFGVAPGTSMETNPIAMNTVFKNTIFTNVASTSDGGVFWEGMES 401
            ||||||||:||.||||||||||||||||||::|||.|:.|:.|||||||||.||||||:|||::.
  Rat   311 DIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDE 375

  Fly   402 SLAPNVQITDWLGKPWTKDSGKPAAHPNSRFCTPAAQCPIIDEAWEDPAGVPISAMLFGGRRPAG 466
            .|||.|.||.|..|.|.....:|.|||||||||||:||||||.|||.|.||||..::||||||||
  Rat   376 PLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAG 440

  Fly   467 VPLIYEARDWTHGVFIGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGDYVAHWLSMEKR-- 529
            |||:|||..|.||||:|||||||||||||||||||||||||||||||||||.|:||||||..|
  Rat   441 VPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPA 505

  Fly   530 GQVPKIFHVNWFRKSAEGKFMWPGYGENSRVLEWILRRVNGESCYVDSAIGHIPAEGALNLDGMK 594
            .::|||||||||||...|||:|||:|||||||||:..|:.||.....:.||::|.|.||||.|:.
  Rat   506 AKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLG 570

  Fly   595 DKVDVKEIFSLPKEFWSQEVKDIRTYFESQVGADLPASIYQQLDELSSRVDNL 647
            | |:|:|:|.:.||||.:||::|..|.|.||.||||..|.::|..|..|:..:
  Rat   571 D-VNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck1	NP_523784.2	PEPCK	54..644	CDD:279197	390/594 (66%)
Pck1	NP_942075.1	PEPCK_GTP	27..615	CDD:238417	391/592 (66%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18197707, ECO:0000269\|PubMed:18772387, ECO:0000269\|PubMed:20476774, ECO:0000269\|PubMed:23127136, ECO:0000269\|PubMed:24863970	235..237		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:18197707, ECO:0000269\|PubMed:18772387, ECO:0000269\|PubMed:20476774, ECO:0000269\|PubMed:23127136, ECO:0000269\|PubMed:24863970	403..405		1/1 (100%)
		Omega-loop. /evidence=ECO:0000269\|PubMed:28345895	457..487		29/29 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353821
Domainoid	1	1.000	546	1.000	Domainoid score	I250
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	827	1.000	Inparanoid score	I436
OMA	1	1.010	-	-		QHG61114
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		otm45437
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	O	PTHR11561
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760