DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pepck1 and Pck2

DIOPT Version :9

Sequence 1:	NP_523784.2	Gene:	Pepck1 / 37131	FlyBaseID:	FBgn0003067	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001101847.2	Gene:	Pck2 / 361042	RGDID:	1311112	Length:	640	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	393/640 - (61%)
Similarity:	481/640 - (75%)	Gaps:	15/640 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LPQL----HKLR---QDNCGLYSHIRGIPISYGNVDLLTTGVRAFVEEGIALCQPDQVHICDGSE 75
            ||.|    |:||   :..|   ..|:.:.:..|::..|..|||.|||....||||..:|||||:|
  Rat     6 LPGLRLSWHRLRPWCRSPC---RSIQTLRVLSGDLSQLPAGVRDFVERSAHLCQPAGIHICDGTE 67

  Fly    76 QENKVLIKSLLEAGTIVPLPKYDNCWLARTNPADVARVESRTFICTERREETIPTPVEGVKGTLG 140
            .||...:..|.|.|.|..||||:|||||||:|.|||||||:|.|.|..:.:|:|....|..|.||
  Rat    68 AENAATLALLEEQGLIRKLPKYENCWLARTDPKDVARVESKTVIVTSSQRDTVPLLAGGASGQLG 132

  Fly   141 NWISPSDMDAAVQQRFPGCMKGRTMYVVPFSMGPVGSPLSKIGIELTDSAYVVASMRIMTRMGAA 205
            ||:||.:...||.|||||||:||||||:||||||:|||||:||::||||.|||||||||||:|..
  Rat   133 NWMSPDEFQRAVDQRFPGCMQGRTMYVLPFSMGPLGSPLSRIGVQLTDSPYVVASMRIMTRLGTH 197

  Fly   206 VLRQLAKKEEFVRALHSVGAPANGQVEQPS-WPCDPERTIILHKPAENLIVSYGSGYGGNSLLGK 269
            ||:.|. ..:|::.|||||.|..|..:... |||:||:|:|.|.|.:..|||:||||||||||||
  Rat   198 VLQALG-DGDFIKCLHSVGQPLTGHGDPVGRWPCNPEKTLIGHVPEQREIVSFGSGYGGNSLLGK 261

  Fly   270 KCFALRIGSTIAKQEGWLAEHMLILGITDPKGEKKYITAAFPSACGKTNLAMLNPSLANYKVECV 334
            |||||||.|.:|:.||||||||||||||:|.|:|:|:.||||||||||||||:.|:|..:|||||
  Rat   262 KCFALRIASRLARDEGWLAEHMLILGITNPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECV 326

  Fly   335 GDDIAWMKFDSQGVLRAINPENGFFGVAPGTSMETNPIAMNTVFKNTIFTNVASTSDGGVFWEGM 399
            |||||||:|||:|.||||||||||||||||||..|||.||.|:..||:|||||.||||||:|||:
  Rat   327 GDDIAWMRFDSEGQLRAINPENGFFGVAPGTSATTNPNAMATIQSNTVFTNVAETSDGGVYWEGI 391

  Fly   400 ESSLAPNVQITDWLGKPWTKDSGKPAAHPNSRFCTPAAQCPIIDEAWEDPAGVPISAMLFGGRRP 464
            :..|.|.|.:|.||||||.....:|.||||||||.||.||||:|.|||.|.||||.|::||||||
  Rat   392 DQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCVPARQCPIMDPAWEAPEGVPIDAIIFGGRRP 456

  Fly   465 AGVPLIYEARDWTHGVFIGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGDYVAHWLSME-- 527
            .||||:|||..|.||||:|:|||||:|||||||||.|||||||||||||||||.|:.||||||
  Rat   457 KGVPLVYEAFSWRHGVFVGSAMRSESTAAAEHKGKTIMHDPFAMRPFFGYNFGHYLEHWLSMEGR 521

  Fly   528 KRGQVPKIFHVNWFRKSAEGKFMWPGYGENSRVLEWILRRVNGESCYVDSAIGHIPAEGALNLDG 592
            |..::|:||||||||:...|:|:|||:|||:|||:||.||:.||....::.||.:|.||||:|.|
  Rat   522 KGARLPRIFHVNWFRRDEAGRFLWPGFGENARVLDWICRRLGGEDSARETPIGLVPKEGALDLSG 586

  Fly   593 MKDKVDVKEIFSLPKEFWSQEVKDIRTYFESQVGADLPASIYQQLDELSSRVDNL 647
            :: .:|..::||:||:||.|||:|||:|...||..|||..:..:|:.|..||..:
  Rat   587 LR-AIDTSQLFSIPKDFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALEERVQKM 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pepck1	NP_523784.2	PEPCK	54..644	CDD:279197	378/592 (64%)
Pck2	NP_001101847.2	PEPCK_GTP	44..633	CDD:238417	379/590 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	291	1.000	Domainoid score	I1476
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3356
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61114
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	LDO	PTHR11561
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.920