Protein Alignment Pepck1 and pck-3

DIOPT Version :10

• Sequence 1: NP_523784.2
• Gene: Pepck1 / 37131
• FlyBaseID: FBgn0003067
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_500887.1
• Gene: pck-3 / 177360
• WormBaseID: WBGene00019151
• Length: 624
• Species: Caenorhabditis elegans
• Alignment Length: 673
• Identity: 164/673 - (24%)
• Similarity: 279/673 - (41%)
• Gaps: 131/673 - (19%)

  Fly    25 RQDNCGLYSHIRGIPISYGNVDLLTTGVRAFVEEGIALCQPDQVHICDGS--------------- 74
            ||.|..:..:...:|:..|::..|:..|..|:.:.:.|..|..|.||:||
 Worm    30 RQHNTLIVPNFGQVPVLKGDLTWLSPEVLTFLNDCVQLMTPCAVRICNGSVFEAQELRDAIANEF 94

  Fly    75 -EQENKVLIKSLLEAGTIVPLPKYDNCWLARTNPADVARVESRTFICTERREETIPTPVEGVKGT 138
             .:|.::|.:..|:...|    .||:..:...:..|.....|.:.....|...:  ...||::..
 Worm    95 GNEEQQMLDRFHLKMADI----GYDDVSVVTKDRLDADPGISLSNASASRTSSS--GSGEGIENV 153

  Fly   139 --LGNWISPSDMDAAVQQRFPGCMKGRTMYVVPFSMGPVGSPLSKIGIELTDSAYVVASMRIMTR 201
              ..:::|....|....:.|...|.||||||||||||.:||..:.:|:::||...:|.::|...|
 Worm   154 RLSSHYMSQKMFDFNKTKLFDCSMSGRTMYVVPFSMGTIGSRRAVVGVQITDDPVLVLNLRTTFR 218

  Fly   202 MGAAVLRQLAKKEEFVRALHSVGAPAN--GQVEQPSWPCDPERTIILHKPAENLIVSYGSGYGGN 264
            :.:.:...:|....|:|.:|::|.|..  .::..||....|..:.::.|..:..:.::|..:|..
 Worm   219 VLSNIWDHIAATTNFLRCVHTIGMPRPIIRKIVTPSPVETPVGSFLVLKHDDQEVWAHGHSFGRT 283

  Fly   265 SLLGKKCFALRIGSTIAKQEGWLAEHMLILGITDPKGEKKYITAAFPSACGKTNLAMLNPSLA-N 328
            ...| |.|::...|.:..::|||||...||.||:||.:..::..   |:....:...|:..|| .
 Worm   284 PRYG-KTFSVHAASWLGAKQGWLAESAAILAITNPKNDTIHVCY---SSLTTIDSLQLSKGLAPG 344

  Fly   329 YKVECVGDDIAWMKFDSQGVLRAINPENGFFGVAPGTSMET--NPIAMNTVFKNTIFTNVASTSD 391
            :||..|.:...|:.: ..|.:...:|||        ..||.  :|       ||  ..|:.:
 Worm   345 WKVTVVSEKSVWLHW-HDGKIYGFSPEN--------DEMEELGSP-------KN--LANLLT--- 388

  Fly   392 GGVFWEGMESSLAPNVQITDWLGKPWTKDSGKPAAHPNSRFCTPAAQCPIIDEAWEDPAGVPISA 456
             ||..|....|..|..          ||                          |....||||||
 Worm   389 -GVISEYQIQSFDPQS----------TK--------------------------WASDVGVPISA 416

  Fly   457 MLFGGRRPAGVPLIYEARDWTHGVFIGAAMR---------SEATAAAEHKG----KVIMHDPFAM 508
            ::|..||....|||.||..|..||.:.|.:|         ||.:.....:|    ::::..|...
 Worm   417 LIFANRRHDQYPLILEANTWEEGVCVAAGIRVSSMKQQKISEESVKESVEGASPRRILVECPMLR 481

  Fly   509 RPFFGYNFGDYVAHWLSME----------KRGQVPKIFHVNWFRKSAEGKFMWPGYGENSRVLEW 563
            .....::...||.|||.|.          :....|:||..|.::: .:||.:|||..:|:|:.|:
 Worm   482 ADAINFSIAKYVKHWLEMGVGVKSSSENFENPPPPQIFFTNLYQE-VDGKPLWPGGVDNARIFEY 545

  Fly   564 ILRRVNGE---SCYVDSAIGHIP----AEGALNLDGMKDKVDVKEIFSLPKEFWSQEVKDIRTYF 621
            |..|....   |..:.|.:|.:|    .....||..:. :||::        ||..|:..:|.:|
 Worm   546 IYERCANPADLSKTISSGLGIVPKTLQLSAGTNLAPLL-QVDIR--------FWLTELNKLRAFF 601

  Fly   622 ESQVGADLPASIYQQLDELSSRV 644
            ..|:...||..:.:.|.:|::.:
 Worm   602 NLQMECSLPPQLDKVLTDLAANL 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pepck1	NP_523784.2	PEPCK_GTP	52..640	CDD:238417	157/640 (25%)
pck-3	NP_500887.1	PEPCK_HprK	57..620	CDD:473983	157/640 (25%)