Protein Alignment Pepck2 and Pck2

DIOPT Version :9

• Sequence 1: NP_611341.1
• Gene: Pepck2 / 37130
• FlyBaseID: FBgn0034356
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_083270.2
• Gene: Pck2 / 74551
• MGIID: 1860456
• Length: 640
• Species: Mus musculus
• Alignment Length: 645
• Identity: 409/645 - (63%)
• Similarity: 486/645 - (75%)
• Gaps: 15/645 - (2%)

  Fly     1 MLLKGAQLLRCGL----VSPHRNSNFRLTCRFLSIQYGDAKILTPAVKQYVEKCVELCQPERVHI 61
            |.|.|.:|.|.||    .||.|      :.:.|.:..||...|...|:.:|.:...|||||.:||
Mouse     4 MYLPGLRLSRHGLRPWCWSPCR------SIQTLHVLSGDMSQLPAGVRDFVARSAHLCQPEGIHI 62

  Fly    62 CDGTEVESKLLQGIMLKKGTIIPLPKYENCWLARTNPADVARVEGKTFISTDSKEQTVPVTEKAT 126
            |||||.|:..:..::.::|.|..||||:|||||||:|.||||||.||.|.|.|:..|||:.....
Mouse    63 CDGTEAENTAILALLEEQGLIRKLPKYKNCWLARTDPKDVARVESKTVIVTPSQRDTVPLLAGGA 127

  Fly   127 PGMLGNWIAEKDMQAAIKERFPGCMKGRTMYVIPFSMGPVGSPLSKIGIEITDSPYVVESMKIMT 191
            .|.||||::..:.|.|:.|||||||:||.|||:||||||||||||:||:::|||.|||.||:|||
Mouse   128 RGQLGNWMSPDEFQRAVDERFPGCMQGRIMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMT 192

  Fly   192 RAGNPVLNYLQSGDGQFVKCLHSVGTPKSG-VQAMPSWPCDPERTIVLHKPAENEIVSYGSGYGG 255
            |.|.|||..|  |||.|:|||||||.|.:| ...:..|||:||:|::.|.|.:.||||:||||||
Mouse   193 RLGTPVLQAL--GDGDFIKCLHSVGQPLTGHGDPVGQWPCNPEKTLIGHVPDQREIVSFGSGYGG 255

  Fly   256 NSLLGKKCLALRIGSTIAKREGWLAEHMLILGITNPQGKKIYIAAAFPSACGKTNLAMMTPTLPG 320
            ||||||||.||||.|.:|:.||||||||||||||||.|||.|:||||||||||||||||.|.|||
Mouse   256 NSLLGKKCFALRIASRLARDEGWLAEHMLILGITNPAGKKRYVAAAFPSACGKTNLAMMRPALPG 320

  Fly   321 YKVECVGDDIAWMKFDNKGVLRAINPENGFFGVAPGTSRATNPIAMDTIFRNSVFTNVASTSDGG 385
            :||||||||||||:||::|.||||||||||||||||||.||||.||.||..|::|||||.|||||
Mouse   321 WKVECVGDDIAWMRFDSEGQLRAINPENGFFGVAPGTSAATNPNAMATIQSNTLFTNVAETSDGG 385

  Fly   386 VYWEGMEKDQLKGVTVTDWLGKLWSQESGKPAAHPNSRFCTPASQCPIIDPAWEDSEGVPISAIL 450
            |||||:::....|||:|.||||.|.....:|.||||||||.||.||||:|||||..|||||.||:
Mouse   386 VYWEGIDQPLPPGVTITSWLGKPWKPGDKEPCAHPNSRFCVPARQCPIMDPAWEAPEGVPIDAII 450

  Fly   451 FGGRRPSGVPLVYEARDWKHGVFIGAAMRSEATAAAEFKGKVIMHDPFAMRPFFGYNFGDYLGHW 515
            ||||||.||||||||.:|:||||:|:|||||:|||||.|||.|||||||||||||||||.||.||
Mouse   451 FGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGKTIMHDPFAMRPFFGYNFGRYLEHW 515

  Fly   516 LSME-QRG-QVPKIFHVNWFRKSSEGKFLWPGFGENSRVLDWIFRRVEGEQCFEDSPIGRLPSKN 578
            |||| |:| ::|:||||||||:...|:|||||||||:||||||.||:|||...:::|||.:|.:.
Mouse   516 LSMEGQKGARLPRIFHVNWFRRDEAGRFLWPGFGENARVLDWICRRLEGEDSAQETPIGLVPKEG 580

  Fly   579 SLNLDSLENIDLDQLFDLPKDFWEQEVAAIERYFEEQVGHHLPGAVAEELRELKARVADM 638
            :|:|..|..:|..|||.:|||||||||..|..|..|||...||..|..||..|:.||..|
Mouse   581 ALDLSGLSAVDTSQLFSIPKDFWEQEVRDIRGYLTEQVNQDLPKEVLAELEALEGRVQKM 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pepck2	NP_611341.1	PEPCK	45..635	CDD:279197	391/592 (66%)
Pck2	NP_083270.2	PEPCK_GTP	44..633	CDD:238417	391/590 (66%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P07379	253..255		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P07379	421..423		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850123
Domainoid	1	1.000	549	1.000	Domainoid score	I256
eggNOG	1	0.900	-	-		E1_COG1274
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	839	1.000	Inparanoid score	I445
Isobase	1	0.950	-	0	Normalized mean entropy	S2278
OMA	1	1.010	-	-		QHG61114
OrthoDB	1	1.010	-	-		D135245at33208
OrthoFinder	1	1.000	-	-		FOG0002991
OrthoInspector	1	1.000	-	-		mtm8845
orthoMCL	1	0.900	-	-		OOG6_102518
Panther	1	1.100	-	-	O	PTHR11561
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4022
SonicParanoid	1	1.000	-	-		X1986
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750